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Biosensors
Special Issues
Feature Papers: State-of-the-Art Biosensors Technology 2018
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Feature Papers: State-of-the-Art Biosensors Technology 2018

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 42749

Special Issue Editors

Dr. Alisa Rudnitskaya

E-Mail Website
Guest Editor
CESAM and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: multisensor systems; electronic tongues; electroanalysis; chemometrics; food analysis; environmental analysis; electrochemical sensors and biosensors
Special Issues, Collections and Topics in MDPI journals
Dr. Beate Strehlitz

E-Mail Website
Guest Editor
Department Environmental and Biotechnology Centre, Helmholtz Centre for Environmental Research – UFZ, Permoserstr. 15, 04318 Leipzig, Germany
Interests: aptamer selection and characterization; SELEX; aptamer based sensors and assays; biosensor development and application; bioelectrotechnology; bioelectrochemistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Donald Y.C. Lie

E-Mail Website
Guest Editor
Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA
Interests: low−power RF/Analog integrated circuits & System−on−a−Chip (SoC) design and test; interdisciplinary research on medical electronics, biosensors & biosignal processing
Special Issues, Collections and Topics in MDPI journals
Dr. Fatih Inci

E-Mail Website
Guest Editor
1. UNAM—National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey
2. Institute of Materials Science and Nanotechnology, Bilkent University, Ankara 06800, Turkey
Interests: microfluidics; lab-on-a-chip; plasmonic biosensors; bionanotechnology; nanoplasmonics; wearable sensors; infectious diseases; HIV/AIDS; cancer research; personalized medicine; point of care diagnostics; mobile health; global health; biomedical engineering; molecular diagnostics; telemedicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Chung-Chih Hung

E-Mail Website
Guest Editor
Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
Interests: analog and mixed-signal integrated circuit design; biomedical integrated circuit design; biomedical engineering; wearable and implantable devices & sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

On behalf of the Biosensors Editorial Board, it is a pleasure to announce this Special Issue, “Feature Papers: State-of-the-Art Biosensors Technology 2018”. Biosensors are devices that use a biological recognition element retained in direct spatial contact with a transduction system (Thevenot D.R., Tòth K., Durst R.A., Wilson G.S. (2001) Electrochemical Biosensors: Recommended Definitions and Classification Pure Appl. Chem. 71 2333). A biosensor converts a biological recognition event into a measurable signal. It consists of a biorecognition element (e.g., enzyme, antibody, tissue, living cell, etc.) that provides selectivity and a transducer (e.g., electrochemical, optical, piezoelectrical, etc.) that converts the biological recognition reaction into a measurable and quantifiable signal. The connected electronics are responsible for signal processing and user-friendly result visualization.

We would like to invite you to submit an article, which will provide an up-to-date perspective in the field, to this Special Issue. We will strictly select papers from excellent scholars around the world to publish for free in this Special Issue to benefit both authors and readers.

Potential topics include, but are not limited to:

  • Immunosensors;
  • Enzymatic biosensors;
  • Whole cell biosensors;
  • DNA based biosensors;
  • Paper-based biosensors;
  • Thick film printed biosensors;
  • Micro- and Nanobiosensors;
  • Biomimetic materials for biosensing (molecularly imprinted polymers, aptamers, odorant binding proteins, etc.);
  • Biomarkers for Diagnostics;
  • Point-of-care applications;
  • Lab-on-a-chip technology;
  • Microfluidic devices;
  • Biomedical engineering;
  • Wearable and implantable sensors;
  • Environmental applications;
  • Further applications, e.g., food industry and control, biotechnology, etc.

Deadline for submission is 31 December, 2018. Authors are welcome to send short proposals for submissions of feature papers to our Editorial Office ([email protected]).

Dr. Alisa Rudnitskaya
Dr. Beate Strehlitz
Prof. Dr. Donald Y.C. Lie
Dr. Fatih Inci
Prof. Dr. Chung-Chih Hung
Guest editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

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15 pages, 4305 KiB  
Article
Detection of Breast Cancer Cells Using Acoustics Aptasensor Specific to HER2 Receptors
by Alexandra Poturnayová, Ľudmila Dzubinová, Monika Buríková, Jozef Bízik and Tibor Hianik
Biosensors 2019, 9(2), 72; https://doi.org/10.3390/bios9020072 - 27 May 2019
Cited by 30 | Viewed by 7260
Abstract
Detection of the breast cancer cells is important for early diagnosis of the cancer. We applied thickness shear mode acoustics method (TSM) for detection of SK-BR-3 breast cancer cells using DNA aptamers specific to HER2 positive membrane receptors. The biotinylated aptamers were immobilized [...] Read more.
Detection of the breast cancer cells is important for early diagnosis of the cancer. We applied thickness shear mode acoustics method (TSM) for detection of SK-BR-3 breast cancer cells using DNA aptamers specific to HER2 positive membrane receptors. The biotinylated aptamers were immobilized at the neutravidin layer chemisorbed at gold surface of TSM transducer. Addition of the cells resulted in decrease of resonant frequency, fs, and in increase of motional resistance, Rm. Using gold nanoparticles (AuNPs), modified by aptamers it was possible improving the limit of detection (LOD) that reached 550 cells/mL, while without amplification the sensitivity of the detection of SK-BR-3 cells was 1574 cells/mL. HER2 negative cell line MDA-MB-231 did not resulted in significant changes of fs. The viability studies demonstrated that cells are stable at experimental conditions used during at least 8 h. AuNPs were not toxic on the cells up to concentration of 1 μg/mL. Full article
(This article belongs to the Special Issue Feature Papers: State-of-the-Art Biosensors Technology 2018)
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12 pages, 2984 KiB  
Article
Differentiation of Patients with Balance Insufficiency (Vestibular Hypofunction) versus Normal Subjects Using a Low-Cost Small Wireless Wearable Gait Sensor
by Tam Q. Nguyen, Jonathan H. Young, Amanda Rodriguez, Steven Zupancic and Donald Y.C. Lie
Biosensors 2019, 9(1), 29; https://doi.org/10.3390/bios9010029 - 26 Feb 2019
Cited by 11 | Viewed by 5616
Abstract
Balance disorders present a significant healthcare burden due to the potential for hospitalization or complications for the patient, especially among the elderly population when considering intangible losses such as quality of life, morbidities, and mortalities. This work is a continuation of our earlier [...] Read more.
Balance disorders present a significant healthcare burden due to the potential for hospitalization or complications for the patient, especially among the elderly population when considering intangible losses such as quality of life, morbidities, and mortalities. This work is a continuation of our earlier works where we now examine feature extraction methodology on Dynamic Gait Index (DGI) tests and machine learning classifiers to differentiate patients with balance problems versus normal subjects on an expanded cohort of 60 patients. All data was obtained using our custom designed low-cost wireless gait analysis sensor (WGAS) containing a basic inertial measurement unit (IMU) worn by each subject during the DGI tests. The raw gait data is wirelessly transmitted from the WGAS for real-time gait data collection and analysis. Here we demonstrate predictive classifiers that achieve high accuracy, sensitivity, and specificity in distinguishing abnormal from normal gaits. These results show that gait data collected from our very low-cost wearable wireless gait sensor can effectively differentiate patients with balance disorders from normal subjects in real-time using various classifiers. Our ultimate goal is to be able to use a remote sensor such as the WGAS to accurately stratify an individual’s risk for falls. Full article
(This article belongs to the Special Issue Feature Papers: State-of-the-Art Biosensors Technology 2018)
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8 pages, 1887 KiB  
Article
Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study
by Helena Ukkonen, Simo Vuokila, Jopi J. W. Mikkonen, Hannah Dekker, Engelbert A. J. M. Schulten, Elisabeth Bloemena, Arto Koistinen, Tulio A. Valdez, Arja M. Kullaa and Surya Pratap Singh
Biosensors 2019, 9(1), 12; https://doi.org/10.3390/bios9010012 - 13 Jan 2019
Cited by 4 | Viewed by 5979
Abstract
Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical [...] Read more.
Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy. Full article
(This article belongs to the Special Issue Feature Papers: State-of-the-Art Biosensors Technology 2018)
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10 pages, 20586 KiB  
Article
Characterization and Inkjet Printing of an RNA Aptamer for Paper-Based Biosensing of Ciprofloxacin
by Jeannine Jaeger, Florian Groher, Jacqueline Stamm, Dieter Spiehl, Johannes Braun, Edgar Dörsam and Beatrix Suess
Biosensors 2019, 9(1), 7; https://doi.org/10.3390/bios9010007 - 2 Jan 2019
Cited by 26 | Viewed by 7254
Abstract
The excessive use of antibiotics in food-producing animals causes a steady rise of multiple antibiotic resistance in foodborne bacteria. Next to sulfonamides, the most common antibiotics groups are fluoroquinolones, aminoglycosides, and ß-lactams. Therefore, there is a need for a quick, efficient, and low-cost [...] Read more.
The excessive use of antibiotics in food-producing animals causes a steady rise of multiple antibiotic resistance in foodborne bacteria. Next to sulfonamides, the most common antibiotics groups are fluoroquinolones, aminoglycosides, and ß-lactams. Therefore, there is a need for a quick, efficient, and low-cost detection procedure for antibiotics. In this study, we propose an inkjet-printed aptamer-based biosensor developed for the detection of the fluoroquinolone ciprofloxacin. Due to their extraordinary high affinity and specificity, aptamers are already widely used in various applications. Here we present a ciprofloxacin-binding RNA aptamer developed by systematic evolution of ligands by exponential enrichment (SELEX). We characterized the secondary structure of the aptamer and determined the KD to 36 nM that allow detection of antibiotic contamination in a relevant range. We demonstrate that RNA aptamers can be inkjet-printed, dried, and resolved while keeping their functionality consistently intact. With this proof of concept, we are paving the way for a potential range of additional aptamer-based, printable biosensors. Full article
(This article belongs to the Special Issue Feature Papers: State-of-the-Art Biosensors Technology 2018)
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Review

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19 pages, 2403 KiB  
Review
A Review of the Construction of Nano-Hybrids for Electrochemical Biosensing of Glucose
by Razia Batool, Amina Rhouati, Mian Hasnain Nawaz, Akhtar Hayat and Jean Louis Marty
Biosensors 2019, 9(1), 46; https://doi.org/10.3390/bios9010046 - 25 Mar 2019
Cited by 83 | Viewed by 15568
Abstract
Continuous progress in the domain of nano and material science has led to modulation of the properties of nanomaterials in a controlled and desired fashion. In this sense, nanomaterials, including carbon-based materials, metals and metal oxides, and composite/hybrid materials have attracted extensive interest [...] Read more.
Continuous progress in the domain of nano and material science has led to modulation of the properties of nanomaterials in a controlled and desired fashion. In this sense, nanomaterials, including carbon-based materials, metals and metal oxides, and composite/hybrid materials have attracted extensive interest with regard to the construction of electrochemical biosensors. The modification of a working electrode with a combination of two or three nanomaterials in the form of nano-composite/nano-hybrids has revealed good results with very good reproducibility, stability, and improved sensitivity. This review paper is focused on discussing the possible constructs of nano-hybrids and their subsequent use in the construction of electrochemical glucose biosensors. Full article
(This article belongs to the Special Issue Feature Papers: State-of-the-Art Biosensors Technology 2018)
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