Next Article in Journal
Enzymatic Low Volume Passive Sweat Based Assays for Multi-Biomarker Detection
Next Article in Special Issue
Differentiation of Patients with Balance Insufficiency (Vestibular Hypofunction) versus Normal Subjects Using a Low-Cost Small Wireless Wearable Gait Sensor
Previous Article in Journal
Acknowledgement to Reviewers of Biosensors in 2018
Previous Article in Special Issue
Characterization and Inkjet Printing of an RNA Aptamer for Paper-Based Biosensing of Ciprofloxacin
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle

Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study

1
Research Group of Oral Health Sciences, Faculty of Medicine, University of Oulu, and Oulu University Hospital, P.O. Box 8000, 90014 Oulu, Finland
2
Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, 90029 Oulu, Finland
3
SIB Labs, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland
4
Institute of Dentistry, University of Eastern Finland, Kuopio campus, and Educational Dental Clinic, Kuopio University Hospital, P.O. Box 1627, 70211 Kuopio, Finland
5
Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
6
Department of Otolaryngology, School of Medicine, Stanford University, Patlo Alto, CA 94305, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biosensors 2019, 9(1), 12; https://doi.org/10.3390/bios9010012
Received: 4 December 2018 / Revised: 9 January 2019 / Accepted: 11 January 2019 / Published: 13 January 2019
(This article belongs to the Special Issue Feature Papers: State-of-the-Art Biosensors Technology 2018)
  |  
PDF [1887 KB, uploaded 13 January 2019]
  |  

Abstract

Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy. View Full-Text
Keywords: FTIR spectroscopy; head and neck cancer; radiotherapy FTIR spectroscopy; head and neck cancer; radiotherapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ukkonen, H.; Vuokila, S.; Mikkonen, J.J.W.; Dekker, H.; Schulten, E.A.J.M.; Bloemena, E.; Koistinen, A.; Valdez, T.A.; Kullaa, A.M.; Singh, S.P. Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study. Biosensors 2019, 9, 12.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biosensors EISSN 2079-6374 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top