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Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study

Research Group of Oral Health Sciences, Faculty of Medicine, University of Oulu, and Oulu University Hospital, P.O. Box 8000, 90014 Oulu, Finland
Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, 90029 Oulu, Finland
SIB Labs, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland
Institute of Dentistry, University of Eastern Finland, Kuopio campus, and Educational Dental Clinic, Kuopio University Hospital, P.O. Box 1627, 70211 Kuopio, Finland
Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Department of Otolaryngology, School of Medicine, Stanford University, Patlo Alto, CA 94305, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biosensors 2019, 9(1), 12;
Received: 4 December 2018 / Revised: 9 January 2019 / Accepted: 11 January 2019 / Published: 13 January 2019
(This article belongs to the Special Issue Feature Papers: State-of-the-Art Biosensors Technology 2018)
PDF [1887 KB, uploaded 13 January 2019]


Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy. View Full-Text
Keywords: FTIR spectroscopy; head and neck cancer; radiotherapy FTIR spectroscopy; head and neck cancer; radiotherapy

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Ukkonen, H.; Vuokila, S.; Mikkonen, J.J.W.; Dekker, H.; Schulten, E.A.J.M.; Bloemena, E.; Koistinen, A.; Valdez, T.A.; Kullaa, A.M.; Singh, S.P. Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study. Biosensors 2019, 9, 12.

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