Mesenchymal Stem Cell Fate and Potential Therapy

Dear Colleagues,

The study of stem cells within mesenchymal systems relates to cells derived from the bone and bone marrow, cartilage, muscle, and connective and adipose tissue. Stems are rare, and they allow the production of precursor cells in adult life that also maintains self-renewal and multilineage differentiation. A small population of multipotent cells has the capacity for their self-renewing and clonogenic capacity to generate progeny cells that are differentiated into various lineages.

Knowing how to identify the stem/progenitor cells to characterize and separate them can allow maintaining them into distinct subpopulations based on both phenotype and function. Stem cell differentiation relies on transcription factors and chromatin remodeling that play a role in the cells’ regulation. The regulation of cell fate decisions is profoundly influenced by systemic and local signals that provide the cells’ niche. Determining the cells’ fate is required both to maintain tissue homeostasis and function in tissue regeneration. The use of progenitor cells with scaffold biomaterial makes them an enormous power for medical devices in a variety of therapeutic applications.

Prof. Dr. Dafna Benayahu
Collection Editor

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