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Mesenchymal Stem Cells as a Promising Cell Source for Integration in Novel In Vitro Models

by Ann-Kristin Afflerbach 1,2,†, Mark D. Kiri 1,†, Tahir Detinis 1,† and Ben M. Maoz 1,3,4,*
1
Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel
2
Faculty of Biosciences, Universität Heidelberg, 69120 Heidelberg, Germany
3
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel
4
The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 6997801, Israel
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(9), 1306; https://doi.org/10.3390/biom10091306
Received: 21 August 2020 / Revised: 2 September 2020 / Accepted: 3 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Mesenchymal Stem Cell Fate and Potential Therapy)
The human-relevance of an in vitro model is dependent on two main factors—(i) an appropriate human cell source and (ii) a modeling platform that recapitulates human in vivo conditions. Recent years have brought substantial advancements in both these aspects. In particular, mesenchymal stem cells (MSCs) have emerged as a promising cell source, as these cells can differentiate into multiple cell types, yet do not raise the ethical and practical concerns associated with other types of stem cells. In turn, advanced bioengineered in vitro models such as microfluidics, Organs-on-a-Chip, scaffolds, bioprinting and organoids are bringing researchers ever closer to mimicking complex in vivo environments, thereby overcoming some of the limitations of traditional 2D cell cultures. This review covers each of these advancements separately and discusses how the integration of MSCs into novel in vitro platforms may contribute enormously to clinical and fundamental research. View Full-Text
Keywords: mesenchymal stem cells; in vitro models; microfluidics; organs-on-a-chip; scaffolds; organoids mesenchymal stem cells; in vitro models; microfluidics; organs-on-a-chip; scaffolds; organoids
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Afflerbach, A.-K.; Kiri, M.D.; Detinis, T.; Maoz, B.M. Mesenchymal Stem Cells as a Promising Cell Source for Integration in Novel In Vitro Models. Biomolecules 2020, 10, 1306.

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