Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Microbial Metabolites, Host Responses and Gastrointestinal Diseases
edited by , and Tahrir Alenezi
submission deadline 20 May 2027 | Viewed by 72 | Submission Open
Keywords: gut homeostasis and disease; inflammation; microbiota; metabolites; microbial factors
(This special issue belongs to the Section Molecular Biology)
Protein Biophysics submission deadline 31 May 2027 | 5 articles | Viewed by 10114 | Submission Open
Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein–ligand interactions; protein–protein interactions; protein–nucleic acid interactions; membrane proteins; liquid–liquid phase separation
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
The Role of Non-Coding RNAs in Health and Disease: 2nd Edition submission deadline 31 May 2027 | 2 articles | Viewed by 2566 | Submission Open
Keywords: non-coding RNA,; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of Antimicrobial Activity and Resistance in Pathogens
edited by
submission deadline 31 May 2027 | 1 articles | Viewed by 1851 | Submission Open
Keywords: MDR profile in fungi; anti-fungal strategies; drug–target interactions; nanotechnology in antimicrobials; quorum-sensing molecular interactions; biofilm
(This special issue belongs to the Section Molecular Biology)
Molecular Engineering and Applications of Protein Cages and Cavities
edited by
submission deadline 31 May 2027 | Viewed by 353 | Submission Open
Keywords: host-guest encapsulation; drug targeting; virus-like nanoparticles; ferritins; cavity-containing biomolecules; vault proteins; encapsulins; nanocompartments; medicinal, materials science, and analytical applications
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Molecular and Cellular Mechanisms in Multiple Sclerosis
edited by and Maria laura Idda
submission deadline 31 May 2027 | Viewed by 305 | Submission Open
Keywords: multiple sclerosis; gene expression; immunophenotyping; molecular-, expression- and protein-quantitative loci QTLs; non-coding RNAs; precision medicine
(This special issue belongs to the Section Molecular Medicine)
Decoding Cellular Pathogenesis of Hypertension: Emerging Mechanisms and Therapeutic Targets
edited by Satoru Eguchi and Yuka Terada
submission deadline 31 May 2027 | Viewed by 279 | Submission Open
Keywords: omics; microbiota; signal transduction; epigenetics; cellular mechanisms
(This special issue belongs to the Section Molecular Medicine)
Biomolecules in Colorectal Cancer: From Bench to Bedside
edited by
submission deadline 31 May 2027 | Viewed by 69 | Submission Open
Keywords: colorectal cancer; biomarkers; precision oncology; perioperative biology; translational medicine
(This special issue belongs to the Section Molecular Medicine)
Deciphering Molecular Landscape and Biomarkers of Tumor Progression for Precision Oncology
edited by Claudia Sabato and
submission deadline 31 May 2027 | Viewed by 44 | Submission Open
Keywords: intratumor heterogeneity dynamics; oncogenic signaling networks; EMT-mediated matrix remodeling; metabolic reprogramming pathway; metastatic dissemination; cancer biomarkers; immune evasion signaling; therapeutic resistance; multi-omics profiling; tumor microenvironment
(This special issue belongs to the Section Molecular Medicine)
Molecular and Cellular Mechanism of Gynecologic Malignancies
edited by and Cezary Miedziarek
submission deadline 10 Jun 2027 | Viewed by 36 | Submission Open
Keywords: gynecological neoplasms; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; gestational neoplastic disease; tumor microenvironment; genomics; transcriptome; metabolomics
(This special issue belongs to the Section Molecular Medicine)
Preclinical: Drug, Model and Imaging Development
edited by Mohamed El-Tanani and
submission deadline 15 Jun 2027 | 1 articles | Viewed by 277 | Submission Open
Keywords: preclinical drug development; disease models; molecular imaging; patient-derived organoids; cancer pharmacology; drug resistance; translational biomarkers; high-content screening; AI-assisted drug discovery; theranostics
(This special issue belongs to the Section Biological Factors)
The Brain-Heart Axis: Neurohumoral and Neuroimmune Pathways in Cardiovascular Pathology
edited by Xiao-Dong Zhang
submission deadline 22 Jun 2027 | Viewed by 17 | Submission Open
Keywords: brain–heart axis; cardiovascular disease; neurohormones; neuroimmune; stress; hypothalamic–pituitary–adrenal axis; sympathetic-adreno-medulla axis; cortisol; inflammation; sympathetic nervous system; parasympathetic nervous system
(This special issue belongs to the Section Biological Factors)
New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition
edited by , and Tarun W. Dasari
submission deadline 30 Jun 2027 | 3 articles | Viewed by 9041 | Submission Open
Keywords: brain–heart axis; heart and stroke; stress-induced cardiomyopathy; cardiovascular disease
(This special issue belongs to the Section Molecular Medicine)
Molecular Pathology, Diagnostics and Therapeutics of Lung Disease: 2nd Edition
edited by
submission deadline 30 Jun 2027 | 1 articles | Viewed by 656 | Submission Open
Keywords: pulmonary diseases; diagnostics; therapeutics
(This special issue belongs to the Section Molecular Medicine)
Cellular and Molecular Basis of Metabolic Alterations in Transplantation submission deadline 30 Jun 2027 | Viewed by 163 | Submission Open
Keywords: mitochondria; bioenergetics; metabolomics; glycolysis; immunometabolism
(This special issue belongs to the Section Chemical Biology)
Dendrimers, Dendrons, and the Dendritic State: A Themed Issue in Honor of Prof. Donald Tomalia submission deadline 30 Jun 2027 | Viewed by 83 | Submission Open
Keywords: dendrimers; dendrons; physical properties; biomedical applications; material applications
(This special issue belongs to the Section Molecular Biology)
Functions and Mechanisms of Protective Biomolecules in Metabolic Diseases
edited by Mirela Baus Lončar, and
submission deadline 20 Jul 2027 | 3 articles | Viewed by 3422 | Submission Open
Keywords: protective biomolecules; metabolic homeostasis; insulin resistance; cancer metabolism
(This special issue belongs to the Section Molecular Medicine)
Multi-Scale Integrative Radiobiology
edited by
submission deadline 20 Jul 2027 | Viewed by 331 | Submission Open
Keywords: integrative radiobiology; radiosensitivity; radiosusceptibility; radiodegeneration; radiation-induced energy microdepositions; radiation-induced radical oxygen species; radiation-induced DNA damage; DNA damage recognition and repair; radiation-induced tissue injuries; radiation-induced risks
(This special issue belongs to the Section Molecular Biology)
Human ABC Transporters in Drug Disposition and Resistance: 50 Years of Progress and Future Perspectives
edited by
submission deadline 31 Jul 2027 | Viewed by 306 | Submission Open
Keywords: ABC transporters; drug disposition; drug resistance; pharmacokinetics; pharmacodynamics; pharmacogenetics; single nucleotide polymorphisms (SNPs)
(This special issue belongs to the Section Chemical Biology)
Natural Small Molecules and Biologics for Targeting Aging and Aging-Associated Diseases
edited by
submission deadline 31 Jul 2027 | Viewed by 60 | Submission Open
Keywords: natural small molecules; biologics; aging; chronic diseases; mitochondrial dysfunction; inflammation; oxidative stress; cellular senescence; metabolic dysregulation
(This special issue belongs to the Section Molecular Medicine)
Digital Twins in Biomedical and Pharmaceutical Research
edited by Shuxing Zhang and Yinan Sun
submission deadline 30 Aug 2027 | Viewed by 250 | Submission Open
Keywords: digital twins; artificial intelligence (AI); big data; drug discovery and development; clinical trials; personalized medicine
(This special issue belongs to the Section Bioinformatics and Systems Biology)
40 Years of Cystic Fibrosis: A Long Journey From the Discovery of the CFTR Gene to the Use of CFTR Protein Modulators and Beyond
edited by , Valeria Rachela Villella and
submission deadline 15 Dec 2027 | Viewed by 212 | Submission Open
Keywords: CFTR variants; CFTR modulators; genetic modifiers; CF therapy; CF models; gene-therapy
(This special issue belongs to the Section Molecular Medicine)
The Biomolecules Journal Club: Highlights on Recent Papers submission deadline 31 Dec 2027 | 1 articles | Viewed by 1006 | Submission Open
Keywords: biomolecules; biomarkers; molecular medicine; proteins; nucleic acids; lipids
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