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Biomolecules
Special Issues
MAPKs in Skin Health and Disease
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MAPKs in Skin Health and Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 10051

Special Issue Editor

Prof. Dr. Sang-Han Lee

E-Mail Website
Guest Editor
School of Food Science & Biotechnology, Food & Bio-Industry Research Institute, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: biochemical assays; assay development; signaling of polyphenolic nutrients; skin aging and melanogenesis, atopic and asthmatic inflammation

Special Issue Information

Dear Colleagues,

Mitogen-activated protein kinases (MAPKs) are major signaling transduction proteins in human skin, which play key roles in skin protection against injurious damage due to factors such as ultraviolet exposure, chemical and physical contact, various antigens and pathogens, and water loss. Skin, which represents one-sixth of the total body weight, is the body’s largest organ, and therefore, the events controling its homeostasis are varied and complicated. Notably, these include the use of MAPKs and related transcription factors.

The objective of this Special Issue, “MAPKs in skin health and disease”, is to publish a collection of the latest review and research papers regarding the signaling events of MAPKs induced by biomocules as well as the molecular targets, biological pathways, and mechanisms of action potentially involved in MAPK signaling in various conditions such as skin cancer, aging, inflammation, and dermatitis. Articles reporting strategies on how to control the beneficial activities of biomolecules by MAPKs in human healthy/aged skin will also be considered. I strongly encourage you and/or your colleagues to submit manuscripts that match the objectives and topics of this Special Issue.

Prof. Dr. Sang-Han Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin
  • health
  • disease
  • antioxidants
  • natural products
  • molecular targets
  • signaling pathways
  • mitogen-activated protein kinases

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Published Papers (2 papers)

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Research

17 pages, 2534 KiB  
Article
Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR–ERK Signaling Pathway
by Shogo Abe, Misako Ueno, Mami Nishitani, Tetsuya Akamatsu, Takumi Sato, Marie Shimoda, Hiroki Kanaoka, Yoshitaka Nii, Hiroko Yamasaki and Keizo Yuasa
Biomolecules 2020, 10(10), 1468; https://doi.org/10.3390/biom10101468 - 21 Oct 2020
Cited by 10 | Viewed by 3702
Abstract
Citrus sudachi is a well-known fruit in Tokushima Prefecture, Japan, and its peels are rich in phytochemicals, including phenolic compounds. Although it is expected that the extract of the C. sudachi peel elicits various beneficial physiological activities, the effect on the skin has [...] Read more.
Citrus sudachi is a well-known fruit in Tokushima Prefecture, Japan, and its peels are rich in phytochemicals, including phenolic compounds. Although it is expected that the extract of the C. sudachi peel elicits various beneficial physiological activities, the effect on the skin has not been investigated. In this study, we report that the aqueous extract from the peel of C. sudachi suppresses cell proliferation of the immortalized human keratinocyte cell line, HaCaT, and primary normal human epidermal keratinocytes. The extract of C. sudachi peel suppressed epidermal growth factor (EGF)-induced EGF receptor activation and tumor necrosis factor (TNF)-α-induced extracellular regulated kinase (ERK) 1/2 activation, which suggests that the extract exerts its inhibitory effect through inhibition of both the EGF receptor (EGFR) and its downstream molecules. Additionally, the extract of C. sudachi peel potentiated calcium-induced keratinocyte differentiation. These results suggest that the extract of C. sudachi peel may have beneficial effects against skin diseases that are characterized by hyperproliferation of epidermal keratinocytes, such as those seen in psoriasis and in cutaneous squamous cell carcinoma. Full article
(This article belongs to the Special Issue MAPKs in Skin Health and Disease)
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12 pages, 2259 KiB  
Article
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib Induces Dry Skin via Decreased in Aquaporin-3 Expression
by Nobutomo Ikarashi, Miho Kaneko, Tomofumi Watanabe, Risako Kon, Makana Yoshino, Takatoshi Yokoyama, Riho Tanaka, Naoya Takayama, Hiroyasu Sakai and Junzo Kamei
Biomolecules 2020, 10(4), 545; https://doi.org/10.3390/biom10040545 - 3 Apr 2020
Cited by 16 | Viewed by 5121
Abstract
An adverse reaction of dry skin occurs frequently during treatment with anticancer epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). In this study, we conducted basic research to clarify the mechanism of EGFR-TKI-induced dry skin and propose new treatments or preventative measures. Dermal [...] Read more.
An adverse reaction of dry skin occurs frequently during treatment with anticancer epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). In this study, we conducted basic research to clarify the mechanism of EGFR-TKI-induced dry skin and propose new treatments or preventative measures. Dermal water content was significantly lower in the erlotinib-treated mice than in the control group. An assessment of the expression levels of functional genes in the skin revealed that only the expression of the water channel aquaporin-3 (AQP3) was significantly decreased in the erlotinib-treated group. When erlotinib was added to epidermal keratinocyte HaCaT cells, the expression levels of both AQP3 mRNA and protein decreased. Erlotinib treatment also significantly decreased the expression levels of phospho-EGFR and phospho-extracellular signal-regulated kinase (ERK), both in HaCaT cells and mouse skin. Dry skin due to erlotinib may be caused by the decreased expression of AQP3 in the skin, thereby limiting water transport from the vascular side to the corneum side. The decrease in AQP3 may also be attributable to ERK suppression via inhibition of EGFR activity by erlotinib. Therefore, substances that increase AQP3 expression may be effective for erlotinib-induced dry skin. Full article
(This article belongs to the Special Issue MAPKs in Skin Health and Disease)
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