Membrane Organization and Protein—Lipid Interactions
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 379
Special Issue Editors
Interests: membrane dynamics; small-GTPases; KRAS; kinases; molecular simulations; protein-membrane simulations
2. Biochemistry and Cell Biology Program, Graduate School of Biomedical Sciences, MD Anderson Cancer Center and University of Texas, Houston, TX 77030, USA
Interests: membrane biology; mechanosensing; ras small GTPases; lipidomics; electron microscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipid bilayers are considered a two-dimensional fluid and have long been thought of as homogeneous mixtures with lipids and proteins distributed evenly in the bilayers. Mounting evidence from super-resolution imaging, quantitative fluorescence imaging, and fractionation assays strongly suggests that biomembranes are highly compartmentalized, with lipids and proteins laterally segregated into nanometer- and/or micrometer-sized domains. Localized enrichment of specific molecules, such as phospholipids, cholesterol, actin, and membrane proteins, within these membrane domains is one of the key factors for how membrane confers their nonpassive role, in addition to their well-established barrier function. Although membrane domains are now more accepted, several important questions remain under investigation. Some of these are:
- How do lipids and membrane proteins undergo spatial segregation in the formation of these membrane domains?
- Do proteolipid assemblies act as signaling platforms to assemble key signaling constituents into scaffolds?
- Do lipids directly participate in the membrane binding and activation of proteins?
- How do the lipids and other membrane constituents influence the conformational dynamics of membrane proteins?
- How does membrane-induced conformation/orientation alter the activation states of a protein, their effector recruitment, and oligomerization states?
- How do membrane domains contribute to cell function?
The goal of this issue is to present a collection of original research articles, review articles, and perspectives primarily addressing membrane domains and their role in protein function with special focus on the above mentioned bullet points.
Dr. Priyanka (Pri) Prakash
Dr. Yong Zhou
Guest Editors
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