Special Issue "Mechanobiology in Health and Disease"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (30 April 2019)

Special Issue Editor

Guest Editor
Prof. Yubing Sun

University of Massachusetts, Amherst
Website | E-Mail
Interests: Stem cell biology; Mechanotransduction; Biomaterials; Tissue Engineering

Special Issue Information

Dear Colleagues,

In various psychological and pathological conditions, the role of mechanical cues, including mechanical forces, material properties of matrices and cells, geometrical confinement, fluid flow, etc., has gained increasing attention over the past three decades. Recent studies start to depict the connections between biomechanical factors and biochemical signals to elucidate the molecular machinery and mechanisms for cells to sense and respond to the complex biophysical microenvironment. This Special Issue aims to include a collection of original research and review articles that facilitate our understanding of biomechanical regulations on cell, tissue, and organ levels. We envision that these works will promote the dissemination of state-of-the-art mechanobiology research outcomes to the broad biology community, and stimulate exciting new ideas and directions.

Prof. Yubing Sun
Guest Editor

Manuscript Submission Information

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Keywords

  • mechanotransduction
  • biophysics
  • matrix stiffness
  • nanotopography
  • morphogenesis
  • tissue engineering
  • biomaterials
  • tumor microenvironment

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Published Papers (1 paper)

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Research

Open AccessArticle
Host-Microbiome Synergistic Control on Sphingolipid Metabolism by Mechanotransduction in Model Arthritis
Biomolecules 2019, 9(4), 144; https://doi.org/10.3390/biom9040144
Received: 6 February 2019 / Revised: 1 April 2019 / Accepted: 3 April 2019 / Published: 9 April 2019
PDF Full-text (2540 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Chronic inflammatory autoimmune disorders are systemic diseases with increasing incidence and still lack a cure. More recently, attention has been placed in understanding gastrointestinal (GI) dysbiosis and, although important progress has been made in this area, it is currently unclear to what extent [...] Read more.
Chronic inflammatory autoimmune disorders are systemic diseases with increasing incidence and still lack a cure. More recently, attention has been placed in understanding gastrointestinal (GI) dysbiosis and, although important progress has been made in this area, it is currently unclear to what extent microbiome manipulation can be used in the treatment of autoimmune disorders. Via the use of appropriate models, rheumatoid arthritis (RA), a well-known exemplar of such pathologies, can be exploited to shed light on the currently overlooked effects of existing therapies on the GI microbiome. In this direction, we here explore the crosstalk between the GI microbiome and the host immunity in model arthritis (collagen induced arthritis, CIA). By exploiting omics from samples of limited invasiveness (blood and stools), we assess the host-microbiome responses to standard therapy (methotrexate, MTX) combined with mechanical subcutaneous stimulation (MS) and to mechanical stimulation alone. When MS is involved, results reveal the sphingolipid metabolism as the trait d’union among known hallmarks of (model) RA, namely: Imbalance in the S1P-S1PR1 axis, expansion of Prevotella sp., and invariant Natural Killer T (iNKT)-penia, thus offering the base of a rationale to mechanically modulate this pathway as a therapeutic target in RA. Full article
(This article belongs to the Special Issue Mechanobiology in Health and Disease)
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