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Dr. Igor Jakovcevski

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Institut für Anatomie und Klinische Morphologie, Universität Witten/Herdecke, 58448 Witten, Germany
Interests: regeneration; spinal cord injury; nerve injury; hippocampus; development

Special Issue Information

Dear Colleagues,

I am pleased to invite you to participate in this Special Issue honoring the contribution of Professor Melitta Schachner to the field of cell adhesion molecules in nervous system development and disease. Prof. Schachner is a world-renowned pioneer in molecular and cellular neurobiology. Prof. Schachner discovered several seminal adhesion molecules which are important in the development of the nervous system, such as L1, CHL1, and tenascins. She was among the first to recognize the importance of the functions of carbohydrates in cell recognition, being able to fine-tune cell interactions in the nervous system. One of her many outstanding achievements was the discovery of signal transduction mechanisms mediated by recognition molecules expressed at the cell surface. Another important achievement was the finding that recognition molecules are important not only for nervous system development but also instrumental in regeneration after nervous system injury and in shaping synapses.

This Special Issue aims to explore the roles of recognition molecules in signal transduction in the development and regeneration of the nervous system.

In this Special Issue, original research articles and reviews are welcome. I look forward to receiving your contributions.

Dr. Igor Jakovcevski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

cell adhesion molecules
extracellular matrix
glycans
nervous system regeneration
nervous system development

Published Papers (1 paper)

Research

21 pages, 3287 KiB

Open AccessEditor’s ChoiceArticle

Mice Mutated in the Third Fibronectin Domain of L1 Show Enhanced Hippocampal Neuronal Cell Death, Astrogliosis and Alterations in Behavior

by Ludovica Congiu, Viviana Granato, Igor Jakovcevski, Ralf Kleene, Luciana Fernandes, Sandra Freitag, Matthias Kneussel, Melitta Schachner and Gabriele Loers

Biomolecules 2023, 13(5), 776; https://doi.org/10.3390/biom13050776 - 29 Apr 2023

Cited by 2 | Viewed by 1565

Abstract

Adhesion molecules play major roles in cell proliferation, migration, survival, neurite outgrowth and synapse formation during nervous system development and in adulthood. The neural cell adhesion molecule L1 contributes to these functions during development and in synapse formation and synaptic plasticity after trauma in adulthood. Mutations of L1 in humans result in L1 syndrome, which is associated with mild-to-severe brain malformations and mental disabilities. Furthermore, mutations in the extracellular domain were shown to cause a severe phenotype more often than mutations in the intracellular domain. To explore the outcome of a mutation in the extracellular domain, we generated mice with disruption of the dibasic sequences RK and KR that localize to position ₈₅₈RKHSKR₈₆₃ in the third fibronectin type III domain of murine L1. These mice exhibit alterations in exploratory behavior and enhanced marble burying activity. Mutant mice display higher numbers of caspase 3-positive neurons, a reduced number of principle neurons in the hippocampus, and an enhanced number of glial cells. Experiments suggest that disruption of the dibasic sequence in L1 results in subtle impairments in brain structure and functions leading to obsessive-like behavior in males and reduced anxiety in females. Full article

(This article belongs to the Special Issue More than Just Adhesion: Recognition Molecules, a Theme Issue Honoring Professor Melitta Schachner)

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More than Just Adhesion: Recognition Molecules, a Theme Issue Honoring Professor Melitta Schachner

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