Pathogenesis and Targeted Therapy of Autoimmune Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 74
Special Issue Editor
Interests: autoimmune rheumatologic diseases; molecular mechanisms and treatment approach; applied immunological basic research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases (ADs) are chronic conditions that affect multiple organs and vary in clinical presentation and disease severity. ADs affect a wide range of people in many parts of the world and have become a major concern in public health.
The development of ADs is intricate, encompassing dysregulation within the immune system, a collapse of immunological tolerance, genetic susceptibilities to the disease, and various environmental factors that can act as triggers.
Traditional treatment strategies for ADs have mainly employed non-specific approaches, including cytotoxic and immunosuppressive drugs. These strategies effectively mitigate the disease's effects, but they are not a complete cure and are often accompanied by adverse reactions. Emerging targeted therapeutic drugs, on the other hand, aim to control and treat ADs by targeting B and T cells or components of the innate immune system, thus inhibiting their activation and function, as well as the abnormal activation of the immune system. A deeper understanding of the pathogenesis of ADs and the exploration of new targeted treatment strategies are essential to advance the treatment of this wide range of complex diseases.
Currently, research in ADs is making continual progress from the perspective of precision medicine, tailored to the patient.
The topic of this Special Issue of Biomedicines, entitled “Pathogenesis and Targeted Therapy of Autoimmune Diseases”, is focused on the novelty in the pathogenesis or treatment of these pathological conditions based on the most recent scientific discoveries. Researchers are invited to contribute with original works and comprehensive reviews focusing on the above.
Dr. Marcella Prete
Guest Editor
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Keywords
- autoimmune diseases
- pathogenesis
- targeted therapy
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