Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research in Congenital Heart Disease (CHD)
edited by Paul Philipp Heinisch
submission deadline 30 Nov 2025 | Viewed by 65 | Submission Open
Keywords: congenital heart disease (CHD); biomaterials; imaging modalities
(This special issue belongs to the Section Molecular and Translational Medicine)
Basic and Clinical Research of Psychiatric Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 62 | Submission Open
Keywords: psychiatric diseases; anxiety disorder; PTSD; schizophrenia; Alzheimer’ s disease; autism spectrum disorder; depression
(This special issue belongs to the Section Molecular and Translational Medicine)
From Cell Dysfunction to Prothrombotic Disorders: Molecular Pathways and Clinical Implications
edited by
submission deadline 30 Nov 2025 | Viewed by 61 | Submission Open
Keywords: prothrombotic disorder; cellular dysfunction; hemostatic balance; thrombosis; novel biomarkers; antithrombotic therapies
(This special issue belongs to the Section Cell Biology and Pathology)
Mechanisms of Cellular Senescence and Inflammation in Cardiovascular Disease
edited by Sivareddy Kotla
submission deadline 30 Nov 2025 | Viewed by 57 | Submission Open
Keywords: cellular senescence; inflammation; cardiovascular disease
(This special issue belongs to the Section Cell Biology and Pathology)
Innovative Therapies for Neurodegenerative Diseases submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open
Keywords: nanotechnology-based therapies; cellular and regenerative therapies; stem cell therapy; gene therapy and RNA interference; protein aggregation inhibitors; neuroinflammation modulators; mitochondrial dysfunction-targeted drugs; preclinical and clinical trials
(This special issue belongs to the Section Gene and Cell Therapy)
Human Dental Stem Cells: The Last 25 Years submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open
Keywords: dental stem cells; regenerative dentistry; differentiation; periodontitis
(This special issue belongs to the Section Cell Biology and Pathology)
Immunological Avalanches: Understanding Immune System Instability in Lupus, IgA Nephropathy, and Transplant Rejection
edited by , Giuseppe Gigliotti and Angelo Ferrantelli
submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open
Keywords: immunological avalanche; lupus nephritis; IgA nephropathy; transplant rejection; complement dysregulation
(This special issue belongs to the Section Immunology and Immunotherapy)
Advances in Pharmacology of Pain and Inflammation
edited by Fernanda Regina de Castro Almeida and Francisco De Assis Oliveira
submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open
Keywords: natural products; chronic pain; neuropathies; oncological pain; anti-inflammatory activity; pulmonary emphysema
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Recent Advances in the Molecular Biology of Transplantation
edited by Anil S. Paramesh
submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open
Keywords: donor-derived cell-free DNA; Torque Teno Virus monitoring; gene expression profiling; kidney/pancreas transplants
(This special issue belongs to the Section Immunology and Immunotherapy)
Gut Microbiota and Cancers of the GI Tract: Role in Regulation, Prevention and Therapy
edited by Luka Bočkor and
submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: gut microbiota; gastrointestinal cancers; gastrointestinal microbiota; anti-cancer therapies
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Advancing Pharmacogenetics and Pharmacogenomics in Pre-Clinical Research: Unveiling New Avenues for Precision Medicine
edited by and
submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; precision medicine; individualized medicine
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Activation and Regulation of NLRP3 Inflammasome
edited by
submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open
Keywords: NLRP3 inflammasome; innate immunity; inflammation; pyroptosis; caspase-1; IL-1β ; IL-18; DAMPs; PAMPs; inflammasome inhibitors; post-translational modifications; chronic inflammatory diseases; metabolic disorders; neurodegenerative diseases; therapeutic targeting
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Human Immunodeficiency Virus (HIV): Past, Present and Future
edited by
submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open
Keywords: HIV latency; ART; HIV reservoirs; NeuroHIV; immune activation; HIV cure strategies; virus– host interactions; HIV comorbidities; HIV and ageing; translational HIV research
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Medically Assisted Reproduction submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open
Keywords: infertility; medically assisted reproduction; reproductive endocrinology; clinical embryology; genetics; artificial intelligence; epigenetics; precision medicine; evidence-based medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Extracellular Matrix in Health and Disorders (2nd Edition)
edited by
submission deadline 15 Dec 2025 | Viewed by 30 | Submission Open
Keywords: ECM; connective tissue; healthy tissues; pathological tissues; imaging; drug targets; markers; dermis; bone; tendon
(This special issue belongs to the Section Molecular and Translational Medicine)
Personalized Treatment in Cancer Research, Second Edition submission deadline 30 Dec 2025 | Viewed by 21 | Submission Open
Keywords: cancer; personalized medicine; personalized treatment; pharmacogenetics; pharmacokinetics; chemotherapy; adjuvant treatment; therapeutic drug monitoring
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies submission deadline 31 Dec 2025 | 6 articles | Viewed by 8107 | Submission Open
Keywords: neurological diseases; neurodegenerative diseases; stroke; multiple sclerosis; epilepsy; neuromuscular disorders; demyelinating diseases; traumatic brain injury; clinical neurophysiology; neuroimaging; genetics; neuropsychological tests; molecular and cellular mechanisms; biomarkers; diagnosis and therapeutics; prognosis; neurorehabilitation
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches submission deadline 31 Dec 2025 | 3 articles | Viewed by 7845 | Submission Open
Keywords: cellular senescence; senescence-associated secretory phenotype; aging; senolytics; senomorphics; senoreverters; therapeutics
(This special issue belongs to the Section Cell Biology and Pathology)
Advanced Research in Neuroprotection
edited by Evangelia Kesidou, Iliana Michailidou and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7431 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood– brain barrier
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Tumor Immune Microenvironment and Novel Strategies for Cancer Immunotherapy
edited by Sidra Islam
submission deadline 31 Dec 2025 | 5 articles | Viewed by 6830 | Submission Open
Keywords: tumor microenvironment cancer immunotherapy; immune markers; tumor infilterating immune cells; tumors
(This special issue belongs to the Section Immunology and Immunotherapy)
Challenges in the Diagnosis and Treatment of Parkinson’s Disease
edited by Iro Boura and Cleanthe Spanaki
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6598 | Submission Open
Keywords: Parkinson’ s disease; diagnosis; treatment; pathophysiology; biomarkers; prodromal; advanced therapies; subtypes; imaging; genetic
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Role of Factors in Embryo Implantation and Placental Development
edited by and Valentina Lacconi
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6553 | Submission Open
Keywords: placental development; implantation; embryo development; pregnancy disorders; endometrium; implantation failure; recurrent pregnancy loss; decidualization
(This special issue belongs to the Section Molecular and Translational Medicine)
Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6333 | Submission Open
Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions
(This special issue belongs to the Section Molecular and Translational Medicine)
Mechanisms, Implications, and Therapeutic Targets in Infectious Diseases
edited by Mihai Lazăr and Oana Săndulescu
submission deadline 31 Dec 2025 | 5 articles | Viewed by 5857 | Submission Open
Keywords: infectious diseases; virus; antibiotics; pathophysiology; molecular mechanism; therapeutic management
(This special issue belongs to the Section Immunology and Immunotherapy)
Advanced Research on Heart Failure and Heart Transplantation submission deadline 31 Dec 2025 | 5 articles | Viewed by 5299 | Submission Open
Keywords: heart failure; heart transplantation; DBD (donation after brain death); DCD (donation after cardiac death); cardiac arrest; ischemic time and reperfusion injury; myocardial damage; preservation techniques; post-transplant outcomes
(This special issue belongs to the Section Molecular and Translational Medicine)
The Promise and Challenge of Induced Pluripotent Stem Cells (iPSCs): 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4541 | Submission Open
Keywords: iPSC; cell differentiation; disease model; disease-in-a-dish; body-on-a-chip; CRISPR/Cas9; gene edition; stem cell therapy; cell transplantation; translational
(This special issue belongs to the Section Molecular and Translational Medicine)
Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches
edited by and Valentina Mercurio
submission deadline 31 Dec 2025 | 6 articles | Viewed by 4513 | Submission Open
Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies
(This special issue belongs to the Section Molecular and Translational Medicine)
Epigenetic Regulation in Cancer Progression
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4091 | Submission Open
Keywords: cancer progression; epigenetic regulation; gene expression; dysregulation; therapeutic targets
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Neurotransmitters in Health and Diseases
edited by and Krisztina Csabafi
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3683 | Submission Open
Keywords: neurotransmitters; GABA; dopamine; glutamate; acetylcholine; neurohormones; neuromodulators
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Nano-Based Drug Delivery and Drug Discovery
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2944 | Submission Open
Keywords: nanotechnology; drug discovery; drug delivery; nanocarriers; nanomaterials; drug targeting; drug release; drug therapeutic
(This special issue belongs to the Section Nanomedicine and Nanobiology)
Traumatic CNS Injury: From Bench to Bedside (2nd Edition)
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2724 | Submission Open
Keywords: neurotrauma; traumatic brain injury; translational science; bench to bedside; neuroprotection
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Antioxidant Materials with Additional Biological Properties
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2706 | Submission Open
Keywords: natural antioxidants; flavonoids; and polyphenols; biocompatible and blood compatible; hydrogel; microgels; nanogel; and particles; polymeric particles; carbon quantum dots; and g-C3N4; stimuli-responsive materials; drug delivery systems; controlled release; and targeted delivery/therapies; antibacterial; antifungal; antiviral; anticancer; and biocidal; ROS-scavenging activity; proteins; enzyme; peptides; and amino acids; activate-able materials and photodynamic therapy
(This special issue belongs to the Section Biomedical Engineering and Materials)
Biological Therapies for Asthma: Targeting Type 1 and Type 2 Inflammation
edited by Mohammad Irshad Reza and Nilesh Sudhakar Ambhore
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2231 | Submission Open
Keywords: asthma endotypes; type 1 inflammation; type 2 inflammation; biological therapies for asthma; non-type 2 asthma; cytokine pathways in asthma; precision medicine in asthma; inflammatory biomarkers in asthma; Th1/Th2 immune responses
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Biomarker and Treatments for Diabetic Neuropathy
edited by Arun V. Krishnan and Tushar Issar
submission deadline 31 Dec 2025 | 4 articles | Viewed by 2202 | Submission Open
Keywords: diabetic peripheral neuropathy; type 1 diabetes; type 2 diabetes; glucagon-like peptide-1 receptor agonists; metabolic syndrome; in vivo corneal confocal microscopy; nerve ultrasonography; obesity; exercise
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Molecular Research in Breast Cancer submission deadline 31 Dec 2025 | 1 articles | Viewed by 2037 | Submission Open
Keywords: breast cancer; apoptosis; signaling pathways; drug resistance; metastasis; cancer stem cells; microRNA; biomarkers; drug target; tumor metabolism; tumor immunity
(This special issue belongs to the Section Molecular and Translational Medicine)
From Molecules to Minds: Translational Breakthroughs in Preclinical Psychiatry submission deadline 31 Dec 2025 | 1 articles | Viewed by 1534 | Submission Open
Keywords: depression; anxiety; bipolar disorder; post-traumatic stress disorder; mental disorders; epigenomics; psychiatric disorders/genetics; circadian rhythm; sex characteristics; mitochondrial dysfunction; neurotoxins; intergenerational transmission; cannabinoid receptor modulators; adolescent neuroplasticity; synaptic pruning; psychoimmunology; preclinical studies; translational medical research; neuroplasticity; neuromodulation; phytochemicals; plant extracts; transcranial magnetic stimulation
(This special issue belongs to the Section Molecular and Translational Medicine)
Liver Disease: Etiology, Pathology, and Treatment
edited by Ivana Mikolašević
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1368 | Submission Open
Keywords: chronic liver disease; metabolic-associated fatty liver disease; liver fibrosis; liver injury; etiology; pathology; molecular and cellular mechanisms; biomarkers and therapeutic targets; immunotherapy; prevention and treatment
(This special issue belongs to the Section Cell Biology and Pathology)
Genetic and Molecular Mechanisms of Cardiometabolic Diseases and Cancers—2nd Edition
edited by Tao Wu and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1133 | Submission Open
Keywords: cardiometabolic disease; oncology; comorbidity; genetic pleiotropy; direct genetic effects; indirect genetic effects; parent-of-origin
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Recent Therapeutic Advances in Parkinson’s Disease
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1128 | Submission Open
Keywords: Parkinson's disease; disease-modifying therapy; continuous dopaminergic stimulation; non-dopaminergic drugs; deep brain stimulation; drug repurposing; immunotherapies; gene therapies
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advances in Hepatology
edited by Yuanwen Chen
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1013 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); alcohol-associated liver disease (ALD); alcohol-associated hepatitis; viral hepatitis; liver cancer; autoimmune liver diseases; liver fibrosis; gut microbiota; neuroimmune; inflammatory mechanisms; oxidative stress; reversibly oxidized human non-mercaptalbumin-1; irreversibly oxidized human non-mercaptalbumin-2 (HNA2)
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research on Psychiatric Disorders
edited by Wen Zhang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 911 | Submission Open
Keywords: psychiatric disorders; artificial intelligence; predictive modeling; personalized treatment strategies; animal experiments; risk factors; multimodal approaches
(This special issue belongs to the Section Molecular and Translational Medicine)
The Gut Microbiome in Early Life and Beyond: Implications for Health and Disease
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 884 | Submission Open
Keywords: gut microbiome; early-life development; DOHaD; microbial dysbiosis; chronic disease; probiotics; prebiotics; microbiome– host interactions; developmental programming; translational research
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Advances in Reproductive Medicine and Health
edited by Athanasios Zikopoulos, Sofoklis Stavros and
submission deadline 31 Dec 2025 | Viewed by 879 | Submission Open
Keywords: reproductive medicine; assisted reproductive technology; fertility preservation; IVF; early pregnancy; miscarriages; proteomics; metabolomics; transcriptomics; infertility; bioethics; cryopreservation; personalized medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Current Trends in Regenerative Medicine submission deadline 31 Dec 2025 | Viewed by 864 | Submission Open
Keywords: regenerative medicine; stem cells; organoids; tissue engineering; gene therapy; cell therapy; biomaterials; personalized medicine
(This special issue belongs to the Section Gene and Cell Therapy)
New Insights in Hematologic Malignancies: From Pathophysiologic Mechanisms to Therapeutic Strategies
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 784 | Submission Open
Keywords: leukemia; hematological malignancies; tumor microenvironment; disease models; precision medicine; immunotherapy; targeted therapy; drug resistance; biomarkers; translational research
(This special issue belongs to the Section Cancer Biology and Oncology)
Pathophysiology of Fatty Acid Metabolism submission deadline 31 Dec 2025 | 1 articles | Viewed by 727 | Submission Open
Keywords: fatty acids; signalling molecules; gene expression; metabolic disorders
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Molecular Genomics of Oral Submucous Fibrosis Pathology
edited by Sanjit Mukherjee
submission deadline 31 Dec 2025 | Viewed by 634 | Submission Open
Keywords: oral submucous fibrosis; gene expression; biomarker; DNA methylation; epigenetic drugs; immune biomarkers; pathology; therapeutic interventions; epithelial mesenchymal transition; cancer stem cell marker
(This special issue belongs to the Section Molecular and Translational Medicine)
Chronic Heart Failure: From Biomarkers to Targeted Therapies
edited by
submission deadline 31 Dec 2025 | Viewed by 628 | Submission Open
Keywords: biomarkers in heart failure; GDMT in heart failure; targeted therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Navigating the Complex Landscape of Non-Communicable Respiratory Diseases: Emerging Challenges and Opportunities
edited by Katya Rigatto
submission deadline 31 Dec 2025 | Viewed by 531 | Submission Open
Keywords: non-communicable respiratory diseases; asthma; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease
(This special issue belongs to the Section Molecular and Translational Medicine)
New Insights in Respiratory Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 496 | Submission Open
Keywords: asthma; COPD; bronchiectasis; genetic; therapeutics
(This special issue belongs to the Section Molecular and Translational Medicine)
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