Artificial Intelligence in Biotechnology

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 847

Special Issue Editors


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Guest Editor
School of Electrical and Data Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia
Interests: AI; digital biology; digital twins; decentralized learning; IoBNT

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Guest Editor
Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic
Interests: biotechnological intelligence; medical AI; cancer diagnostics; predictive healthcare

Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) is revolutionizing biotechnology, facilitating intelligent, data-driven approaches to analyze biological complexity, enhance diagnostics, and optimize bioprocesses. Advances in machine learning, deep learning, and intelligent systems can be utilized for numerous tasks, ranging from multi-omics integration to real-time biosensor analysis and personalized healthcare solutions. Notably, AI has shown great promise in accelerating cancer diagnostics, prognosis prediction, and therapeutic response modeling.

This Special Issue, “Artificial Intelligence in Biotechnology”, aims to compile original research papers and comprehensive reviews that explore the integration of AI across various biotechnological domains. Topics of interest include, but are not limited to, the following:

  1. AI-driven optimization in bioprocess and fermentation engineering;
  2. Machine learning for genomics, transcriptomics, and proteomics integration;
  3. Deep learning applications in cancer diagnostics and imaging;
  4. Digital twins of biological systems for predictive modeling;
  5. Internet of Bio-Nano Things (IoBNT) and embedded AI for biosensing;
  6. AI in synthetic biology and genetic circuit design;
  7. Federated learning and decentralized AI for biomedical applications;
  8. AI-guided drug discovery and bio-manufacturing.

Contributions on all research areas are welcome, provided that artificial intelligence is central to the methodology or innovation.

Dr. Mohammad (Behdad) Jamshidi
Dr. Omid Moztarzadeh
Guest Editors

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Keywords

  • artificial intelligence (AI)
  • biotechnology
  • machine learning
  • deep learning
  • digital twins
  • multi-omics integration
  • cancer diagnostics
  • synthetic biology
  • internet of bio-nano things (IoBNT)
  • drug discovery

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Published Papers (1 paper)

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15 pages, 1138 KB  
Systematic Review
Diagnostic Support in Dentistry Through Artificial Intelligence: A Systematic Review
by Alessio Danilo Inchingolo, Grazia Marinelli, Arianna Fiore, Liviana Balestriere, Claudio Carone, Francesco Inchingolo, Massimo Corsalini, Daniela Di Venere, Andrea Palermo, Angelo Michele Inchingolo and Gianna Dipalma
Bioengineering 2025, 12(11), 1244; https://doi.org/10.3390/bioengineering12111244 - 13 Nov 2025
Viewed by 555
Abstract
Background/Objectives: The integration of artificial intelligence (AI) into dental diagnostics is rapidly evolving, offering opportunities to improve diagnostic precision, reproducibility, and accessibility of care. This systematic review examined the clinical performance of AI-based diagnostic tools in dentistry compared with traditional methods, with [...] Read more.
Background/Objectives: The integration of artificial intelligence (AI) into dental diagnostics is rapidly evolving, offering opportunities to improve diagnostic precision, reproducibility, and accessibility of care. This systematic review examined the clinical performance of AI-based diagnostic tools in dentistry compared with traditional methods, with particular attention to radiographic assessment, orthodontic classification, periodontal disease detection, and other relevant specialties. Methods: Comprehensive searches of PubMed, Scopus, and Web of Science were carried out for articles published from January 2015 to June 2025, in accordance with PRISMA guidelines. Only English-language clinical studies investigating AI applications in dental diagnostics were included. Fifteen studies fulfilled the inclusion criteria and underwent quality appraisal and risk-of-bias assessment. Results: Across diverse dental fields, AI systems showed encouraging diagnostic capabilities. Radiographic algorithms enhanced lesion detection and anatomical landmark identification, while machine learning models successfully classified malocclusions and periodontal status. Photographic image analysis demonstrated potential in geriatric and preventive care. However, methodological variability, limited sample sizes, and the absence of external validation constrained generalizability. Study quality ranged from high to moderate, with some reports affected by bias or incomplete data reporting. Conclusions: AI holds considerable promise as an adjunct in dental diagnostics, particularly for imaging-based evaluation and clinical decision support. Broader clinical adoption will require methodological harmonization, rigorous multicenter trials, and validation of AI systems across diverse patient populations. Full article
(This article belongs to the Special Issue Artificial Intelligence in Biotechnology)
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