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Bioengineering
Special Issues
Nano–Bio Interface—Second Edition
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Nano–Bio Interface—Second Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 732

Special Issue Editors

Dr. Zicheng Deng

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Guest Editor
Department of Child Health, The University of Arizona, Phoenix, ZA, USA
Interests: nanoparticle design; gene and drug delivery; pulmonary vascular disease; lung regenerative medicine; cancer diagnosis and therapy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Donglu Shi

E-Mail Website
Guest Editor
The Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA
Interests: nanoscience in biomedicine; biomedical engineering; biosensing and detecting rare events for safe built environment
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yilong Wang

E-Mail Website
Guest Editor
The Institute for Translational Nanomedicine, Shanghai East Hospital, the Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China
Interests: multifunctional nanostructures for biomedical applications; cancer liquid biopsy

Special Issue Information

Dear Colleagues,

The nano–bio interface, where nanoscale materials and biological systems meet, has become a focal point of research and innovation in various fields, including medicine, agriculture, environmental science, and materials science. This Special Issue of Bioengineering aims to bring together cutting-edge research at the forefront of this exciting and dynamic field.

We invite researchers, scientists, and experts from across the globe to contribute original research articles, reviews, and perspectives that explore the nano–bio interface. Topics of interest include, but are not limited to, the following:
  • Nanoparticles for Drug Delivery: novel approaches to and developments in using nanoparticles for targeted drug delivery, gene therapy, and personalized medicine;
  • Biomaterials and Tissue Engineering: Advances in the design and characterization of nanomaterials for tissue engineering, regenerative medicine, and biocompatible implants;
  • Nanotechnology in Diagnostics: The development of nanoscale biosensors, imaging techniques, and diagnostic tools for early disease detection and monitoring;
  • Nanotoxicology and Safety Assessment: Investigations into the potential toxicological effects of nanomaterials and the development of safe-by-design nanostructures;
  • Biological Interactions at the Nanoscale: Understanding the interactions between nanomaterials and biological systems, including cell–nanoparticle interactions and protein adsorption;
  • Nanoparticles in Agriculture and Food Science: Applications of nanotechnology in agriculture, food safety, and preservation;
  • Environmental Implications of Nanotechnology: Assessments of the environmental impact of nanomaterials and the development of eco-friendly nanomaterials.

Dr. Zicheng Deng
Prof. Dr. Donglu Shi
Prof. Dr. Yilong Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanotoxicology
  • drug delivery
  • tissue engineering
  • diagnostics
  • environmental health

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Related Special Issue

Published Papers (3 papers)

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Research

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28 pages, 4876 KB  
Article
Evaluating the Molecular Basis of Nanocalcium-Induced Health Regulation in Zebra Fish (Danio rerio)
by Madhubala Kumari, Aastha Tiwary, Rishav Sheel, Arnab Roy Chowdhury, Biplab Sarkar, Koel Mukherjee and Dipak Maity
Bioengineering 2025, 12(10), 1016; https://doi.org/10.3390/bioengineering12101016 - 24 Sep 2025
Abstract
The present study aimed to evaluate the impact of varying dietary concentrations of calcium oxide nanoparticles (CaO-NPs) on important health regulators in Zebra fish (Danio rerio) using integrative physiological, histopathological, and computational approaches. The co-precipitation method was used to synthesize NPs and [...] Read more.
The present study aimed to evaluate the impact of varying dietary concentrations of calcium oxide nanoparticles (CaO-NPs) on important health regulators in Zebra fish (Danio rerio) using integrative physiological, histopathological, and computational approaches. The co-precipitation method was used to synthesize NPs and characterization was performed through DLS, XRD, FESEM, EDX, and FTIR depicting spherical-shaped CaO-NPs with a hydrodynamic diameter of 91.2 nm. Adult Danio rerio were administered with three different feed regimes enriched with 2.4 (T1), 1.6 (T2), and 0.8 (T3) mg CaO-NPs/kg for 30 days. Growth, survival, NP accumulation, and histological assessments, and bioinformatic studies, were performed to understand interactions of NPs with fish metabolic proteins. The T3 group demonstrated the highest survival (75%) and weight gain (+39.31%), and exhibited the lowest accumulation of CaO-NPs in the brain (0.133 mg/L), liver (0.642 mg/L), and intestine (0.773 mg/L) with no evident histological alterations, whereas T1 group exhibited major liver and intestinal damage. Molecular docking targeting the NRF-2 oxidative stress pathway revealed strong binding affinities of NPs with catalase (−3.7), keap1a (−3.5), keap1b (−3.3), and mafk (−2.4), highlighting potential modulation of redox homeostasis. Hence, a 0.8mg CaO-NPs/kg feed dose is recommended to promote potential health benefits in Danio rerio, which can be further applicable to commercial aquaculture for enhanced fish health while minimizing toxicity. Full article
(This article belongs to the Special Issue Nano–Bio Interface—Second Edition)
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25 pages, 1950 KB  
Article
Revisiting the Mechanical Work–Energy Framework in Dynamic Biomechanical Systems
by Donglu Shi
Bioengineering 2025, 12(9), 977; https://doi.org/10.3390/bioengineering12090977 - 15 Sep 2025
Viewed by 372
Abstract
The classical definition of mechanical work, W = F × D, assumes that work depends solely on force magnitude and displacement, independent of loading rate. However, biological tissues exhibit inherent rate sensitivity—muscles demonstrate velocity-dependent force generation governed by Hill’s force–velocity relationship, while connective [...] Read more.
The classical definition of mechanical work, W = F × D, assumes that work depends solely on force magnitude and displacement, independent of loading rate. However, biological tissues exhibit inherent rate sensitivity—muscles demonstrate velocity-dependent force generation governed by Hill’s force–velocity relationship, while connective tissues and joints show load-rate-dependent stiffness and injury thresholds. These rate effects profoundly influence mechanical work, energy dissipation, and functional outcomes. In this work, we revisit the work–energy framework within biomechanics and biomaterials contexts, combining theoretical models, simulations, and a proposed rate-matched nano–bio indentation experiment to quantify how loading rate modulates energy partitioning between recoverable elastic storage and irreversible viscous dissipation. Our analyses span muscle contraction, viscoelastic tissue mechanics, and nanoparticle–membrane interactions, revealing that rapid loading markedly increases viscous dissipation and total mechanical work, even when peak force and displacement remain constant. We demonstrate that classical quasi-static formulations underestimate energy costs and tissue stresses by neglecting temporal dynamics and nonlinear material responses. Our multi-physics experimental–simulation platform bridges this gap, enabling controlled investigation of rate-dependent biomechanical phenomena at the nano–bio interface. These insights inform biomaterials design by emphasizing rate-matching viscoelastic properties to native tissues and guide experimental biomechanics toward capturing full dynamic histories. This unified framework advances understanding of rate-dependent mechanical work, improving predictive modeling, optimizing therapeutic delivery, and enhancing design in sports science, orthopedics, rehabilitation, and nanomedicine. Full article
(This article belongs to the Special Issue Nano–Bio Interface—Second Edition)
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Review

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51 pages, 8270 KB  
Review
Advances of Functional Two-Dimensional Nanomaterials in the Treatment of Oral Diseases
by Ziyi Xu, Rong Meng, Yue Wang, Yuxuan Sun, Jiao Qiao, Yang Yao and Qiang Peng
Bioengineering 2025, 12(10), 1021; https://doi.org/10.3390/bioengineering12101021 - 25 Sep 2025
Abstract
Two-dimensional (2D) nanomaterials have attracted growing attention in the field of oral medicine due to their unique physicochemical properties, including high surface area, adjustable surface chemistry, and exceptional biocompatibility. In recent years, a variety of 2D materials, including graphene-based nanomaterials, black phosphorus nanosheets, [...] Read more.
Two-dimensional (2D) nanomaterials have attracted growing attention in the field of oral medicine due to their unique physicochemical properties, including high surface area, adjustable surface chemistry, and exceptional biocompatibility. In recent years, a variety of 2D materials, including graphene-based nanomaterials, black phosphorus nanosheets, MXenes, layered double hydroxides (LDHs), transition metal dichalcogenides (TMDs), 2D metal–organic frameworks (MOFs), and polymer-based nanosheets, have been extensively explored for the treatment of oral diseases. These functional materials demonstrate multiple therapeutic capabilities, such as antibacterial activity, reactive oxygen species (ROS) scavenging, anti-inflammatory modulation, and promotion of tissue regeneration. In this review, we systematically summarize the recent advances of 2D nanomaterials in the treatment of common oral diseases such as dental caries, periodontitis, oral cancer and peri-implantitis. The underlying therapeutic mechanisms are also summarized. Challenges for clinical translation of these nanomaterials and the possible solutions are discussed as well. Full article
(This article belongs to the Special Issue Nano–Bio Interface—Second Edition)
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