Development of Treatment Agents for Neurodegenerative Disorders Using Enzyme Inhibitors
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 331
Special Issue Editor
Interests: monoamine oxidase inhibitors; acetylcholinesterase inhibitors; pharmaceutical biochemistry; cell wall lytic enzyme; laccase enzyme; rumen microbial metagenome; microorganism with host
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Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) and Parkinson’s disease (PD) constitute major diseases among neurodegenerative disorders. Many researchers have focused on the development of therapeutic agents, including the molecular mechanisms of the diseases in detail. However, only a small amount of progress has been made due to the complex causes of those diseases. In this Special Issue, we aim to target several important enzymes such as monoamine oxidase (MAO), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase 1 (BACE1). MAO catalyzes the oxidative deamination of neurotransmitter monoamines, and it is critically related to amyloid plaque formation in AD. Isoform MAO-B is expressed at high levels in the AD brain with secretases, and it is also related to PD. AChE hydrolyzes neurotransmitter acetylcholine and is also the main target in the palliative therapy of AD, being present in both central and peripheral nervous system and in muscular motor plaques. BchE, present in the brain peripheral tissues and in the serum, is up-regulated in advanced AD. BACE1 is an aspartic acid protease and it is the major β-secretase for the generation of β-amyloid in the neurons. Additionally, anti-β-amyloid aggregation, neuroprotective activities, and related inflammation can be important areas of study.
We are inviting researchers to submit manuscripts to this Special Issue on the issue of the “Development of Treatment Agents for Neurodegenerative Disorders Using Enzyme Inhibitors”. Both experimental articles and comprehensive reviews are welcome.
Prof. Dr. Hoon Kim
Guest Editor
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Keywords
- neurodegenerative disorders
- Alzheimer’s disease
- Parkinson’s disease
- monoamine oxidase
- C-cholinesterase
- β-secretase 1
- β-amyloid aggregation
- neuroprotective activity
- inflammation
- inhibitors
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