Application of Extracellular Matrix in Regenerative Medicine

Dear Colleagues,

I invite you to contribute to a Special Issue of the journal Applied Biosciences and Bioengineering, entitled “Application of Extracellular Matrix in Regenerative Medicine”, which aims to present recent developments in the use of decellularized tissues and bioscaffolds to promote constructive tissue remodeling and wound repair.

An extracellular matrix (ECM) is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells, which forms an intricate network in equilibrium with the surrounding cells and growth factors. The composition and structure of the ECM are a function of its location within tissues and organs, age of the host, and the physiologic requirements of the tissue. Consequently, the ECM can be considered nature's ideal biological scaffold material. Decellularization techniques facilitate the isolation of ECM from the host cells and the resulting bioscaffolds are increasingly being used to promote constructive tissue repair and restoration of normal tissue function following injury.

The decellularization of tissues and whole organs has established a platform for creating scaffolding materials for tissue engineering and regenerative medicine. Novel discoveries regarding the role ECM plays in modulating the host immune response, regulating stem cell differentiation and renewal, and regulating cancer cell behavior continue to be made. Therefore, I cordially invite you to submit your research on these topics in the form of original research papers, mini-reviews, and perspective articles.

Dr. Neill Turner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.