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Applied Sciences
Special Issues
Advances in Biodegradable Micro- and Nanoparticles
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Advances in Biodegradable Micro- and Nanoparticles

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 1753

Special Issue Editors

Prof. Marco Biondi

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples “Federico II”, via Domenico Montesano 49, 80131 Napoli, Italy
Interests: preparation of micro- and nanoparticles for controlled or targeted drug delivery; pharmaceutical applications of zeolitic materials
Special Issues, Collections and Topics in MDPI journals
Dr. Laura Mayol

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples “Federico II”, via Domenico Montesano 49, 80131 Napoli, Italy
Interests: biomaterial science and technology for drug delivery; regenerative medicine; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the most recent developments in the field of biodegradable microparticles intended for biomedical, agricultural, and environmental applications. Biodegradable materials are of special interest since they do not pose any issues regarding their excretion from the biological milieu or removal from the environment.

The upcoming Special Issue of Applied Sciences, entitled “Advances in Biodegradable Micro- and
Nanoparticles”, is devised as a collection of articles reporting both concise reviews of recently obtained results and new findings produced in this broad research area.

The major topics include but are not limited to the current state-of-the-art on real or potential microparticle biomedical, agricultural or environmental applications. Related fields, such as material science, polymer chemistry, and/or innovative techniques to design, prepare, and characterize microparticles are also warmly welcome.

Dr. Marco Biondi
Dr. Laura Mayol
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microparticles
  • drug delivery
  • sustained release
  • depot
  • biodegradable
  • biocompatibility
  • material science
  • polymer chemistry

Published Papers (1 paper)

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Research

12 pages, 2876 KiB  
Article
How Poloxamer Addition in Hyaluronic-Acid-Decorated Biodegradable Microparticles Affects Polymer Degradation and Protein Release Kinetics
by Teresa Silvestri, Barbara Immirzi, Giovanni Dal Poggetto, Paola Di Donato, Valentina Mollo, Laura Mayol and Marco Biondi
Appl. Sci. 2021, 11(16), 7567; https://doi.org/10.3390/app11167567 - 18 Aug 2021
Cited by 1 | Viewed by 1345
Abstract
Polymeric microparticles (MPs) designed for the intravitreal administration of therapeutic proteins result in a prolonged half-life in the vitreous and can delay or discourage the onset of adverse effects inevitably related to this route of administration. Hence, here we designed MPs composed of [...] Read more.
Polymeric microparticles (MPs) designed for the intravitreal administration of therapeutic proteins result in a prolonged half-life in the vitreous and can delay or discourage the onset of adverse effects inevitably related to this route of administration. Hence, here we designed MPs composed of a polymeric blend based on poly(lactic-co-glycolic) acid and poloxamers, externally decorated with hyaluronic acid. The MPs are intended for intravitreal administration of bovine serum albumin. In detail, a systematic formulative study aiming to shed light on the complex relationship between protein release rate and MP degradation rate was carried out by means of calorimetric and gel permeation chromatography analyses. We found out that poloxamer addition caused a compact MP matrix, which led to a slight modification of the degradation kinetics and a reduction in the initial BSA initial release, which is of the utmost importance to ensure a relatively regular BSA release. It must also be underlined that for acid-labile molecules such as proteins, the poloxamer’s presence induced complex and hardly predictable effects on MP degradation/protein release, due to the dynamic balance between the time-evolving hydrophilicity of MPs and the influence of poloxamers themselves on the PLGA degradation rate. Full article
(This article belongs to the Special Issue Advances in Biodegradable Micro- and Nanoparticles)
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