Stem Cells: Latest Advances and Future Perspectives

Dear Colleagues,

The medicine of the future is personalized, powered by artificial intelligence, and focused on safer and more efficient therapeutic strategies. Stem cells are among the key players in the development of personalized regenerative medicine, disease, and implantation modeling. Different types of stem cells, including embryonic stem cells, induced pluripotent stem cells, and adult stem cells can be isolated from various tissues and organs using diverse protocols that influence their capacity for self-renewal, differentiation, and therapeutic potential. In addition, cancer stem cells represent a critical subpopulation involved in tumor initiation, progression, metastasis, and therapy resistance, making them an important target for modern cancer research.

A deeper understanding of the practical aspects of stem cell isolation, in vitro maintenance, characterization, and differentiation is essential for advancing effective stem cell-based therapies and disease modeling approaches.

In this Special Issue, our goal is to bring together high-quality research and review articles highlighting recent advances in both fundamental and applied stem cell studies, including cancer stem cells and their biomedical applications.

Topics of interest include, but are not limited to, the following areas:

• Opportunities and challenges in the use of stem cells and cancer stem cells in vivo and in vitro.
• Techniques for the isolation, culture, characterization and differentiation of human and animal stem cells.
• Disease and implantation modeling using stem cells.
• Cancer stem cells: biology, signaling pathways, therapeutic targeting, and drug resistance.
• Applications of stem cells in medicine (dentistry, orthopedics, cardiology, neurology, oncology, wound healing, endocrinology, etc.).

Dr. Mihail S. Chervenkov
Dr. Darin Zerti
Dr. Elena N. Stoyanova
Guest Editors

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