Special Issue "Antimicrobial Peptides - Discovery, Structure, Function, and Application"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".

Deadline for manuscript submissions: 31 August 2022.

Special Issue Editors

Prof. Dr. Shirley W. I. Siu
E-Mail Website
Guest Editor
Institute of Science and Environment, University of Saint Joseph, Rua de Londres 106, Macau
Interests: computer-aided drug design; docking; molecular dynamics; cheminformatics; machine learning; therapeutic peptides; GPCR; ion channels
Prof. Dr. François-Xavier Campbell-Valois
E-Mail Website
Guest Editor
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada
Interests: molecular and cellular microbiology; host-pathogen interactions; anti-infective drugs and alternative therapeutic strategies
Prof. Dr. Watshara Shoombuatong
E-Mail Website
Guest Editor
Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
Interests: bioinformatics; immunoinformatics; machine learning; drug discovery and development
Dr. Siti Azma Jusoh
E-Mail Website
Guest Editor
Structural Bioinformatics & Molecular Modeling Lab, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300, Bandar Puncak Alam, Selangor, Malaysia
Interests: computer-aided drug design; docking; molecular dynamics; membrane proteins; nuclear receptors; COVID-19 inhibitors; flaviviridae virus

Special Issue Information

Dear Colleagues,

The emergence of multidrug-resistant bacteria (MDR) has become a global health crisis, affecting our ability to treat infectious diseases and leading to increasing morbidity and mortality. New treatment options are therefore urgently needed to eradicate MDR bacteria. Among them, antimicrobial peptides (AMPs) are emerging as promising antibiotic agents due to their remarkable broad-spectrum antibacterial properties and lower probability of bacterial resistance development. To date, more than 3000 AMPs have been discovered from nature, and many more chemically modified synthetic peptides with improved biological activities have been developed. Nevertheless, the successful translational applications of AMPs are very limited. On the one hand, our incomplete understanding of how these peptides work hinders their development into therapeutics. On the other hand, the relatively high production costs, short half-life, low bioavailability, and potential toxic side effects of AMPs compared to conventional small molecule drugs make them less attractive to study through the established drug discovery pipeline. Addressing these challenges requires a deeper understanding of AMPs and innovative techniques to discover and design potent AMPs that are relevant to clinical applications.

In this Special Issue, we aim to collect and disseminate the latest experimental and computational works on the discovery and characterization of AMPs, in terms of their structures, functions and potential applications. Manuscripts from original research and review articles are invited. Submitted manuscripts will be peer-reviewed to ensure high quality of contributions in this issue.

Prof. Dr. Shirley W. I. Siu
Prof. Dr. François-Xavier Campbell-Valois
Prof. Dr. Watshara Shoombuatong
Dr. Siti Azma Jusoh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antimicrobial peptides
  • antibacterial peptides
  • antibiotics
  • bioinformatics
  • host defense peptides
  • multidrug-resistance bacteria
  • peptide sequence
  • peptide structure
  • peptide design
  • peptide drug discovery
  • peptide therapeutics
  • secretions
  • toxins

Published Papers

This special issue is now open for submission.
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