Special Issue "Benefits of Bacteriophages to Combat Antibiotic-Resistant Bacteria"
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 23927
Interests: bacteriophages; endolysins; phage therapy; biocontrol; Staphylococcus aureus; biofilms
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Bacteriophages are important players in microbial communities, modulating bacterial growth and evolution. They also contribute to pathogenicity by providing virulence factors and antibiotic resistance genes, which can be further spread in the bacterial population. Indeed, phages might be vehicles for horizontal exchange of genetic material by transduction, in some cases resulting in bacteria with increased resistance to therapeutic drugs. Recently, in Western countries, bacteriophages have been proposed as an attractive alternative to antibiotics (phage therapy) for the treatment of bacterial infections. However, the risk that a massive use of bacteriophages may contribute to the development of antibiotic resistance through the transmission of genetic material is an as of yet unsolved problem. Moreover, although the real contribution of therapeutic phages to the diffusion of resistance has not been precisely defined, it seems clear that phages are important reservoirs of resistance genes. Despite these drawbacks, progress in new technologies, such as genome editing and synthetic biology, offers a wide variety of possibilities to generate phages with adequate properties for prophylactic and therapeutic applications. Some examples of strategies to improve phages intended for phage therapy include deletion of undesirable genes, expanding phage host range or disrupting some capsid epitopes to eliminate immune responses. Our possibilities can go even further by using phages that deliver CRISPR-Cas systems and sensitize bacteria to antibiotics, thereby facilitating the replacement of antibiotic-resistant pathogens with their sensitive counterparts. The main subject of this Special Issue includes any bacteriophage-based approach to prevent or control antibiotic resistant bacteria, especially human pathogenic bacteria. The issue welcomes various submission types, such as original research papers, short communications, reviews, case reports, and perspectives. Potential topics include phage therapy (human and veterinary medicine), prophylactic applications of phages (development of vaccine platforms), and the use of phage genome engineering or CRISPR-Cas-based phage engineering to obtain phages suitable for reducing antibiotic-resistant bacteria.
Dr. Pilar García Suárez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Antibiotic resistance
- phage therapy
- synthetic biology
- genome engineering