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Antibiotics
Special Issues
Infectious Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Visual Outcomes
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Infectious Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Visual Outcomes

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 4276

Special Issue Editors

Dr. Kuan-Jen Chen

E-Mail Website
Guest Editor
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou branch, Taoyuan, Taiwan
Interests: infectious endophthalmitis; bacterial or fungal endophthalmitis; clinical and experimental endophthalmitis; antibiotic susceptibility and resistance; management of endophthalmitis
Dr. Yi-Hsing Chen

E-Mail Website
Guest Editor
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou branch, Taoyuan, Taiwan
Interests: clinical and experimental uveitis; infectious endophthalmitis

Special Issue Information

Dear Colleagues,  

Infectious endophthalmitis is a rare sight-threatening intraocular infection that can occur following ocular surgery or trauma, as well as through the hematogenous spread of microorganisms from endogenous infection. Prompt administration of intravitreal antibiotics with or without pars plana vitrectomy is crucial for preventing severe vision loss. Endophthalmitis can be caused by a variety of bacterial and fungal pathogens. The development of infectious endophthalmitis can range from rapidly progressive fulminant infection to a chronic, indolent course. Management and diagnosis of intraocular infections can be challenging, and multiple factors may lead to significant ocular morbidity, which can destroy ocular tissues. 

We are pleased to invite you to submit articles related to the infectious endophthalmitis, including experimental and clinical endophthalmitis. Original research articles and reviews are welcome. Research areas may include (but are not limited to) pathogens, clinical settings, diagnosis and detection, management and outcomes, antibiotic susceptibility and resistance, and antibiotic toxicity.

We look forward to receiving your contributions.

Dr. Kuan-Jen Chen
Dr. Yi-Hsing Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial endophthalmitis
  • fungal endophthalmitis
  • exogenous endophthalmitis
  • endogenous endophthalmitis
  • experimental endophthalmitis
  • antimicrobial agents
  • antibiotic susceptibility and resistance

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Published Papers (2 papers)

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Research

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9 pages, 907 KiB  
Article
Emerging Antibiotic Resistance Patterns Affect Visual Outcome Treating Acute Endophthalmitis
by Xia-Ni Wu, Yi-Hsing Chen, Lazha Sharief, Ahmed Al-Janabi, Nura Al Qassimi, Sue Lightman and Oren Tomkins-Netzer
Antibiotics 2022, 11(7), 843; https://doi.org/10.3390/antibiotics11070843 - 23 Jun 2022
Cited by 7 | Viewed by 1635
Abstract
Background: Examining the effect of antibiotic resistance, use of intravitreal antibiotics and systemic corticosteroids on visual outcome of eyes with acute endophthalmitis. Methods: We included 226 eyes with acute endophthalmitis, treated using a standardized protocol. Visual outcome up to 12 months was assessed [...] Read more.
Background: Examining the effect of antibiotic resistance, use of intravitreal antibiotics and systemic corticosteroids on visual outcome of eyes with acute endophthalmitis. Methods: We included 226 eyes with acute endophthalmitis, treated using a standardized protocol. Visual outcome up to 12 months was assessed related to biopsy results, antibiotics resistance and treatment regimens. Results: Vitreous biopsies were more likely to be culture-positive (41.1%) than anterior chamber biopsies (21.6%, p < 0.0001). Antibiotic resistance for amikacin was found in 19 eyes (24.7%), vancomycin in 29 eyes (31.5%) and moxiflocacin in 14 eyes (16.1%). At presentation 91.53% of eyes had BCVA < 20/40, reducing by 1 month to 69.94% (p < 0.0001) and remaining stable at 12 months. There was no difference in visual outcome for those receiving early systemic corticosteroids. Endophthalmitis following cataract surgery (OR 1.66, 1.04–2.66 95% CI, p = 0.03) and receiving intravitreal vancomycin (OR 3.15, 1.18–8.42 95% CI, p = 0.02) were associated with a greater chance of final BCVA ≥ 20/40. Conclusion: Using vitreous taps with intravitreal antibiotics, despite an increase in resistance to both vancomycin and moxifloxacin, results in a final BCVA > 20/200 in half of eyes and ≥20/40 in a third. Early treatment with intravitreal antibiotics should not be delayed. Full article
(This article belongs to the Special Issue Infectious Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Visual Outcomes)
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Review

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11 pages, 275 KiB  
Review
Endophthalmitis in Silicone Oil-Filled Eyes
by Magdalene Yin Lin Ting, Soyang Ella Kim and Rodrigo Anguita
Antibiotics 2023, 12(4), 736; https://doi.org/10.3390/antibiotics12040736 - 10 Apr 2023
Cited by 2 | Viewed by 2055
Abstract
Incidences of post pars plana vitrectomy (PPV) endophthalmitis vary between 0.02% and 0.13%, and infectious endophthalmitis in silicone oil-filled eyes is even rarer. We performed a literature review to describe the incidence, protective and predisposing factors, causative pathogens, management options, and prognosis of [...] Read more.
Incidences of post pars plana vitrectomy (PPV) endophthalmitis vary between 0.02% and 0.13%, and infectious endophthalmitis in silicone oil-filled eyes is even rarer. We performed a literature review to describe the incidence, protective and predisposing factors, causative pathogens, management options, and prognosis of infectious endophthalmitis in silicone oil-filled eyes. Various studies have elucidated different aspects of this condition. Causative pathogens commonly include commensals. Traditional management involves the removal of silicone oil (SO), intravitreal antibiotics and then SO re-injection. Alternatively, injecting intravitreal antibiotics into silicone oil-filled eyes has also been reported. Visual prognoses are uniformly guarded. Due to the uncommon nature of this condition, studies are limited either by their retrospective design or by small sample sizes. However, observational studies, case series, and case reports can play an important role in rare conditions until larger studies are conducted. This comprehensive review aims to summarise the information available in the literature, to act as a good source for ophthalmologists looking for answers on this topic, and to suggest areas for future development. Full article
(This article belongs to the Special Issue Infectious Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Visual Outcomes)
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