Immune Responses to Antibiotic Exposure or Treatment

Dear Colleagues,

Antibiotics are chemical foreign bodies in the body, and the antibiotics themselves or their metabolites will also react with the immune system, producing favorable or unfavorable effects. In recent years, research pertaining to the effect of antibiotics on the body's immunity has been active, and many varieties of antibacterial drugs have shown an effect not related to the antibacterial effect of the drug itself, but related to the regulation of the host's immune response. In addition, in antibiotic treatment, on the one hand, antibiotics can directly target pathogenic bacteria, in order to play a selective anti-infection role. On the other hand, they can also play a role in regulating inflammation in infectious diseases and other inflammatory conditions, by affecting cytotoxic factors or down-regulating pro-inflammatory cytokines and phagocytic oxidative products. This Special Issue focuses on immune responses to antibiotic exposure or treatment. We welcome contributions to immunology, biology, and medical research related to the study of molecular mechanisms of immune regulation and their impact on the body's immune response during antibiotic exposure or treatment.

The actions of prokaryotic cell-directed antibiotic agents are generally considered safe in mammalians, including humans. Recent advances in bacteria-specific antibiotic actions have been associated with their direct interference with eukaryotic cellular functions, as well as immunity via diverse molecular actions. Moreover, antibiotic exposure or treatment may cause dysbiotic microbial community changes in the normal microbiota, which can be detrimental or beneficial to mammalian immune systems, including humans and livestock animals. The present issues can also discuss any immunological event caused by the misuse or overuse of antibiotic agents or anti-biofilm agents in clinics and farms. Any issues linked to acute and chronic inflammatory, malignant, or immunological diseases that are associated with antibiotic exposure or treatments are also recommended. Furthermore, antibiotic exposure- or treatment-linked changes in microbiota comprise another interesting area that may affect the immune system and other immune-linked adverse outcomes. The present Special Issues deal with antibiotic agent-associated actions in immune responses and their clinical implications in humans and animals. However, antibiotic agents are not limited to antibacterial agents, but can include other diverse types of anti-microbial agents against fungi, protists, or parasitic animals.  

Prof. Dr. Yuseok Moon
Prof. Dr. Sik Yoon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• antibiotic agents
• immunity
• dysbiosis of microbiota
• inflammation
• antibiotic exposure
• antibiotic treatment