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Antibiotics
Special Issues
Antimicrobial Compounds from Microorganisms
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Antimicrobial Compounds from Microorganisms

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 14576

Special Issue Editors

Prof. Dr. Junying Ma

E-Mail Website
Guest Editor
South China Seas Institute of Oceanography Chinese Academy of Sciences, Guangzhou, China
Interests: discovery, biosynthesis and mechanism of marine actinomycete derived anti-infective cyclic peptides
Prof. Dr. Linghong Meng

E-Mail Website
Guest Editor
Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
Interests: marine natural products
Dr. Ling Liu

E-Mail Website
Guest Editor
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Interests: fungal secondary metabolites; marine natural products; drug discovery; genome mining; biosynthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microorganisms have become an important source of new chemical substances with antimicrobial biological activities. A wide range of compound classes such as alkaloids, quinones, phenols, polyketides, and terpenoids have been reported from various sources of endophytic microorganisms, and some of these compounds have been evidenced to possess significant antimicrobial properties such as penicillin, the famous well-developed and marketed antibiotic that can be produced by endophytic fungi. The discovery and large-scale use of antibiotics have resulted in effective control of mortality from pathogen infections. However, the diversity of pathogens and their increasingly serious antibiotic resistance require the development of new antibiotics. Therefore, this Special Issue seeks manuscript submissions including antimicrobial compounds from microorganisms

Prof. Dr. Junying Ma
Prof. Dr. Linghong Meng
Prof. Dr. Ling Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Secondary metabolites
  • Bioactive compounds
  • Antimicrobial activity
  • Microorganism
  • Molecular diversity

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Published Papers (2 papers)

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Research

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19 pages, 3207 KiB  
Article
Antimicrobial Profile of Actinomycin D Analogs Secreted by Egyptian Desert Streptomyces sp. DH7
by Dina H. Amin, Hayam A. E. Sayed, Ahmed M. Elissawy, Dina E. EL-Ghwas and Abdel Nasser B. Singab
Antibiotics 2021, 10(10), 1264; https://doi.org/10.3390/antibiotics10101264 - 18 Oct 2021
Cited by 6 | Viewed by 2759
Abstract
Egyptian deserts are an underexplored ecological niche, especially the Sinai Peninsula. In our recent study, we explored this extreme environment and shed light on the bioactive capabilities of desert Actinobacteria isolated from Sinai. Fifty desert Actinobacteria were isolated from the Sinai desert using [...] Read more.
Egyptian deserts are an underexplored ecological niche, especially the Sinai Peninsula. In our recent study, we explored this extreme environment and shed light on the bioactive capabilities of desert Actinobacteria isolated from Sinai. Fifty desert Actinobacteria were isolated from the Sinai desert using mineral salt media, basal media, and starch casein media. The filtrate of Streptomyces sp. DH 7 displayed a high inhibitory effect against multidrug-resistant Staphylococcus aureus (MRSA) strains. The 16S rDNA sequencing confirmed that isolate DH7 belongs to the genus Streptomyces. The NJ phylogenetic tree showed relatedness to the Streptomyces flavofuscus strain NRRL B-2594 and Streptomyces pratensis strain ch24. The minimum inhibitory concentrations against MRSA were 16 and 32 μg/μL. Chemical investigation of the ethyl acetate extract of Streptomyces sp. DH7 led to the isolation and purification of natural products 1–4. Structure elucidation of the purified compounds was performed using detailed spectroscopic analysis including 1 and 2D NMR, and ESI-MS spectrometry. To the best of our knowledge, this is the first report for the isolation of compounds 1–4 from a natural source, while synthetic analogs were previously reported in the literature. Compounds 3–4 were identified as actinomycin D analogues and this is the first report for the production of actinomycin D analogs from the Sinai desert with an inhibitory effect against MRSA. We indorse further study for this analog that can develop enhanced antimicrobial activities. We confirm that the desert ecosystems in Egypt are rich sources of antibiotic-producing Actinobacteria. Full article
(This article belongs to the Special Issue Antimicrobial Compounds from Microorganisms)
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Review

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20 pages, 758 KiB  
Review
Antimicrobial Compounds from Microorganisms
by Cynthia Amaning Danquah, Prince Amankwah Baffour Minkah, Isaiah Osei Duah Junior, Kofi Bonsu Amankwah and Samuel Owusu Somuah
Antibiotics 2022, 11(3), 285; https://doi.org/10.3390/antibiotics11030285 - 22 Feb 2022
Cited by 43 | Viewed by 10976
Abstract
Antimicrobial resistance is an exigent public health concern owing to the emergence of novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance. An influx of new antimicrobials is urgently required to improve the treatment outcomes of infectious diseases and [...] Read more.
Antimicrobial resistance is an exigent public health concern owing to the emergence of novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance. An influx of new antimicrobials is urgently required to improve the treatment outcomes of infectious diseases and save lives. Plant metabolites and bioactive compounds from chemical synthesis have found their efficacy to be dwindling, despite some of them being developed as drugs and used to treat human infections for several decades. Microorganisms are considered untapped reservoirs for promising biomolecules with varying structural and functional antimicrobial activity. The advent of cost-effective and convenient model organisms, state-of-the-art molecular biology, omics technology, and machine learning has enhanced the bioprospecting of novel antimicrobial drugs and the identification of new drug targets. This review summarizes antimicrobial compounds isolated from microorganisms and reports on the modern tools and strategies for exploiting promising antimicrobial drug candidates. The investigation identified a plethora of novel compounds from microbial sources with excellent antimicrobial activity against disease-causing human pathogens. Researchers could maximize the use of novel model systems and advanced biomolecular and computational tools in exploiting lead antimicrobials, consequently ameliorating antimicrobial resistance. Full article
(This article belongs to the Special Issue Antimicrobial Compounds from Microorganisms)
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