Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.3
4.3
Journals
Antibiotics
Special Issues
Genetic Mechanisms of Bacterial Survival: Antibiotic Resistance and Defense Strategies
share announcement

Genetic Mechanisms of Bacterial Survival: Antibiotic Resistance and Defense Strategies

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 557

Special Issue Editors

Dr. Caio Augusto Martins Aires

E-Mail Website
Guest Editor
Department of Health Sciences, Federal Rural University of The Semiarid Region (UFERSA), Mossoró, RN, Brazil
Interests: carbapenemases; gram-negative bacilli; ESBL; one health approach
Dr. Thiago Pavoni Gomes Chagas

E-Mail Website
Guest Editor
1. Department of Pathology, School of Medicine, Universidade Federal Fluminense, Niterói, RJ, Brazil
2. Molecular Epidemiology and Biotechnology Laboratory (LEMB), Faculty of Pharmacy, Universidade Federal Fluminense, Niterói, RJ, Brazil
Interests: antimicrobial resistance; one health; genetics of microorganisms

Special Issue Information

Dear Colleagues,

Bacteria have developed diverse genetic mechanisms that enhance their survival in hostile environments, particularly against antibiotics. These strategies, such as mutations, horizontal gene transfer, efflux pumps, enzymatic degradation, and biofilm formation, enable bacteria to resist not only antibiotics but also other antimicrobial agents like disinfectants, biocides, antiseptics, and heavy metals. Antibiotic resistance, driven by these mechanisms, poses a significant threat to global health. Rapid resistance spread through horizontal gene transfer emphasizes the need for constant vigilance. Early detection of resistance genes and robust surveillance systems are crucial for controlling the rise of resistant infections. Advanced“omics”technologies offer deeper insights into these mechanisms, aiding in developing new treatments. This Special Issue encourages submissions that expand our understanding of bacterial survival strategies, particularly against a wide range of antimicrobial agents.

Dr. Caio Augusto Martins Aires
Dr. Thiago Pavoni Gomes Chagas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance mechanisms
  • disinfectant and antiseptic resistance
  • biofilm formation
  • genomic insights
  • horizontal gene transfer

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 556 KiB  
Article
Prevalence and Variability of Helicobacter pylori Clarithromycin Resistance Mutations in Pediatric Patients in Poland: A Genotypic Analysis Using the Bosphore Genotyping Kit
by Tomasz Bogiel, Anna Szaflarska-Popławska and Agnieszka Krawczyk
Antibiotics 2025, 14(4), 352; https://doi.org/10.3390/antibiotics14040352 - 31 Mar 2025
Viewed by 315
Abstract
Background: Helicobacter pylori is a Gram-negative bacterium responsible for various gastrointestinal diseases, including peptic ulcers and gastric cancer. Despite available antibiotic therapies, increasing resistance to clarithromycin—a key antibiotic in eradication regimens—poses a significant challenge. This resistance is primarily linked to point mutations in [...] Read more.
Background: Helicobacter pylori is a Gram-negative bacterium responsible for various gastrointestinal diseases, including peptic ulcers and gastric cancer. Despite available antibiotic therapies, increasing resistance to clarithromycin—a key antibiotic in eradication regimens—poses a significant challenge. This resistance is primarily linked to point mutations in the 23S rRNA gene, particularly A2143G, A2142G, and A2142C, which hinder clarithromycin binding, reducing its bacteriostatic efficacy. This study aimed to assess the prevalence and variability of clarithromycin resistance mutations in pediatric patients from Bydgoszcz, Poland. Methods: A total of 45 gastric biopsy samples from pediatric patients were analyzed using the Bosphore® Helicobacter pylori Genotyping Kit v1 to detect clarithromycin resistance-associated mutations. Results: Among the 45 tested samples, 30 were classified as wild-type, while 12 contained resistance-associated mutations. The most frequently detected mutation was A2143G (58.3%), followed by A2142G (33.3%). One sample exhibited both A2142G and A2143G mutations, and another contained a mixture of wild-type and mutant strains. The A2142C mutation was not detected in any sample. Conclusions: Our findings confirm the predominance of A2143G among clarithromycin-resistant H. pylori strains, consistent with global trends. The detection of both mutant and wild-type strains in a single patient highlights potential co-infections or subpopulations with varying resistance profiles. Continuous surveillance and improved diagnostic tools are crucial for optimizing treatment strategies. Tailored eradication protocols based on resistance profiling are necessary to enhance treatment efficacy and mitigate the spread of resistant strains. Further research is needed to understand the clinical implications of mixed infections and double mutations in H. pylori resistance development. Full article
(This article belongs to the Special Issue Genetic Mechanisms of Bacterial Survival: Antibiotic Resistance and Defense Strategies)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop