The Models for Antimicrobial Compounds Testing

Dear Colleagues,

More than 35000 people die from antimicrobial-resistant infections in the EU/EEA each year. The multidrug resistance hurdle combined with the fact that only two new classes of antibiotics were developed in the last 40 years, points out for the urgency to find alternatives to antibiotics. Novel compounds are generally screened in vitro to assess their effectiveness and potential toxicity, and then successful candidates proceed to pre-clinical trials using animal models, including insects like Galleria mellonella, and Drosophila melanogaster, nematodes like Caenorhabditis elegans, and mammals, before clinical trials in humans. To tackle the worldwide problem of antibiotic resistance, the establishment of infection models to study microbial infections and assess the efficacy of novel and conventional antimicrobials is crucial. This Special Edition focuses on “The Models for Antimicrobial Compounds Testing” and may include original research, review articles, and short communications. We are interested in qualitative and quantitative research on the use of different animal models for drug screening of new and conventional antimicrobials, and their use in resistance-related microbial infection research. Research on alternative in vitro models for drug screening is also welcome.

Dr. Isa D. Serrano
Dr. Manuela Oliveira
Guest Editors

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