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Antibiotics
Special Issues
Novel Delivery Systems and Approaches for Antibiotics: Recent Advances and...
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Novel Delivery Systems and Approaches for Antibiotics: Recent Advances and Future Directions

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 6919

Special Issue Editors

Dr. Aoife M Rodgers

E-Mail Website
Guest Editor
Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland
Interests: vaccines; vaccination; innate immunity; delivery technologies; intradermal; host-pathogen interactions
Special Issues, Collections and Topics in MDPI journals
Dr. Aaron J. Courtenay

E-Mail Website
Guest Editor
School of Pharmacy and Pharmaceutical Sciences, Ulster University, Cromore Road, Londonderry BT52 1SA, UK
Interests: clinical pharmaceutics; polymeric formulation; diagnostics; drug delivery; vaccination; antimicrobial stewardship
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antibiotics, alongside vaccines, are one of medicine’s greatest interventions, having revolutionized the treatment of serious bacterial infections that would otherwise cause significant morbidity and mortality worldwide. However, despite saving millions of lives, antibiotic use is not without repercussions, inducing negative effects on the host, which have only recently begun to be acknowledged. Moreover, the increasingly frequent acquisition of multidrug-resistant strains has threatened the usefulness of the currently available antibiotics. Added to this threat is the limited discovery and development of novel antimicrobials. To tackle this problem, researchers have begun to utilize advanced pharmaceutical formulation as a means to develop novel delivery systems for the enhanced delivery and therapeutic efficacy of antibiotics, while concomitantly mitigating the negative effects induced to the host.

In this context, we encourage and appreciate the presentation of this Special Issue entitled “Novel Delivery Systems and Approaches for Antibiotics: Recent Advances and Future Directions”. These articles will encapsulate the current dynamism of this field, focusing on recent advancements in the development and evaluation of novel delivery approaches for antibiotics. Contributions addressing novel approaches to minimizing the negative effects of antibiotics in the host will also be appreciated.

We encourage your submission to this exciting Special Issue, with a short turnaround time for publication.

Dr. Aoife M Rodgers
Dr. Aaron J Courtenay
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics
  • infectious disease
  • delivery approaches
  • antimicrobial resistance

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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19 pages, 2872 KiB  
Article
Antimicrobial and Hemostatic Diatom Biosilica Composite Sponge
by Sol Youn, Mi-Ran Ki, Ki Ha Min, Mohamed A. A. Abdelhamid and Seung Pil Pack
Antibiotics 2024, 13(8), 714; https://doi.org/10.3390/antibiotics13080714 - 30 Jul 2024
Cited by 1 | Viewed by 1291
Abstract
The 3D nanopatterned silica shells of diatoms have gained attention as drug delivery vehicles because of their high porosity, extensive surface area, and compatibility with living organisms. Tooth extraction may result in various complications, including impaired blood clotting, desiccation of the root canal, [...] Read more.
The 3D nanopatterned silica shells of diatoms have gained attention as drug delivery vehicles because of their high porosity, extensive surface area, and compatibility with living organisms. Tooth extraction may result in various complications, including impaired blood clotting, desiccation of the root canal, and infection. Therapeutic sponges that possess multiple properties, such as the ability to stop bleeding and kill bacteria, provide numerous advantages for the healing of the area where a tooth has been removed. This study involved the fabrication of a composite material with antibacterial and hemostatic properties for dental extraction sponges. We achieved this by utilizing the porous nature and hemostatic capabilities of diatom biosilica. The antibiotic used was doxycycline. The gelatin-based diatom biosilica composite with antibiotics had the ability to prevent bleeding and release the antibiotic over a longer time compared to gelatin sponge. These properties indicate its potential as a highly promising medical device for facilitating rapid healing following tooth extraction. Full article
(This article belongs to the Special Issue Novel Delivery Systems and Approaches for Antibiotics: Recent Advances and Future Directions)
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16 pages, 4411 KiB  
Article
Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the Treatment of Osteomyelitis
by Elliot Simpson, Humera Sarwar, Iain Jack and Deborah Lowry
Antibiotics 2024, 13(3), 208; https://doi.org/10.3390/antibiotics13030208 - 22 Feb 2024
Cited by 4 | Viewed by 1688
Abstract
Chitosan nanoparticle delivery systems have the potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to [...] Read more.
Chitosan nanoparticle delivery systems have the potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nanoparticles exhibited substantial antimicrobial efficacy, particularly against P. aeruginosa and MRSA, with zones of inhibition ranging from 13 to 24 mm and a complete reduction in colony forming units observed between 3 and 24 h. These chitosan nanoparticle formulations loaded with antimicrobials hold promise for addressing orthopedic complications. Full article
(This article belongs to the Special Issue Novel Delivery Systems and Approaches for Antibiotics: Recent Advances and Future Directions)
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Review

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17 pages, 1686 KiB  
Review
Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems
by Adelaide Mensah, Aoife M. Rodgers, Eneko Larrañeta, Lyndsey McMullan, Murtaza Tambuwala, John F. Callan and Aaron J. Courtenay
Antibiotics 2023, 12(6), 1073; https://doi.org/10.3390/antibiotics12061073 - 19 Jun 2023
Cited by 8 | Viewed by 3178
Abstract
With the advancement of biomedical research into antimicrobial treatments for various diseases, the source and delivery of antibiotics have attracted attention. In periodontal diseases, antibiotics are integral in positive treatment outcomes; however, the use of antibiotics is with caution as the potential for [...] Read more.
With the advancement of biomedical research into antimicrobial treatments for various diseases, the source and delivery of antibiotics have attracted attention. In periodontal diseases, antibiotics are integral in positive treatment outcomes; however, the use of antibiotics is with caution as the potential for the emergence of resistant strains is of concern. Over the years, conventional routes of drug administration have been proven to be effective for the treatment of PD, yet the problem of antibiotic resistance to conventional therapies continues to remain a setback in future treatments. Hydrogels fabricated from natural and synthetic polymers have been extensively applied in biomedical sciences for the delivery of potent biological compounds. These polymeric materials either have intrinsic antibacterial properties or serve as good carriers for the delivery of antibacterial agents. The biocompatibility, low toxicity and biodegradability of some hydrogels have favoured their consideration as prospective carriers for antibacterial drug delivery in PD. This article reviews PD and its antibiotic treatment options, the role of bacteria in PD and the potential of hydrogels as antibacterial agents and for antibiotic drug delivery in PD. Finally, potential challenges and future directions of hydrogels for use in PD treatment and diagnosis are also highlighted. Full article
(This article belongs to the Special Issue Novel Delivery Systems and Approaches for Antibiotics: Recent Advances and Future Directions)
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