Special Issue "Discovery and Functional Evaluation of Antimicrobials"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editors

Dr. Kandasamy Saravanakumar
E-Mail Website
Guest Editor
Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea.
Interests: Microbial Biotechnology;Fungal Biology;Antimicrobial agents;Fungal metabolites;Biocontrol agents;Biomaterials
Prof. Dr. Myeong-Hyeon Wang
E-Mail Website
Guest Editor
College of Biomedical Sciences, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea
Interests: Plant biotechnology;Bio-active material;Molecular biology

Special Issue Information

Dear Colleagues,

The emergence of new and existing highly virulent pathogens and their antibiotic resistance have been encountered as significant problems in bio-health therapeutics. Potential antimicrobials are predominantly available in natural resources (microorganism, plants, and animals) and are safer than those of synthetic origin. Some studies have reported that natural molecules are effective against deadly pathogens. However, those studies are preliminary and unsuccessful at the host level due to the consequences of inadequate characterization and molecular elucidation that lead to failure in clinical clearance. Thus, extensive molecular studies are a prerequisite in natural antimicrobials research. Therefore, this Special Issue aims to focus on the keen evaluation of antimicrobials from natural resources, applying advanced molecular techniques and animal experiments, including but not limited in scope to:

  • The isolation of antimicrobials from natural resources;
  • Antimicrobial resistance;
  • Pharmacology;
  • Antimicrobial-related nanomaterials;
  • Molecular and structural elucidation

Dr. Kandasamy Saravanakumar
Prof. Dr. Myeong-Hyeon Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antimicrobials
  • Virulence
  • Biomolecules
  • Functional evaluation
  • Chemistry

Published Papers (2 papers)

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Research

Open AccessArticle
Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties
Antibiotics 2021, 10(1), 86; https://doi.org/10.3390/antibiotics10010086 - 18 Jan 2021
Viewed by 502
Abstract
This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation [...] Read more.
This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO2 and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO2/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO2/Ag, Ag and TiO2 alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO2/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO2. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells. Full article
(This article belongs to the Special Issue Discovery and Functional Evaluation of Antimicrobials)
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Open AccessArticle
Virulence Characteristics and Antibiotic Resistance Profiles of Shiga Toxin-Producing Escherichia coli Isolates from Diverse Sources
Antibiotics 2020, 9(9), 587; https://doi.org/10.3390/antibiotics9090587 - 08 Sep 2020
Cited by 1 | Viewed by 709
Abstract
Shiga toxin-producing Escherichia coli (STEC) is an enteric pathogen that causes several gastrointestinal ailments in humans across the world. STEC’s ability to cause ailment is attributed to the presence of a broad range of known and putative virulence factors (VFs) including those that [...] Read more.
Shiga toxin-producing Escherichia coli (STEC) is an enteric pathogen that causes several gastrointestinal ailments in humans across the world. STEC’s ability to cause ailment is attributed to the presence of a broad range of known and putative virulence factors (VFs) including those that encode Shiga toxins. A total of 51 E. coli strains belonging to serogroups O26, O45, O103, O104, O113, O121, O145, and O157 were tested for the presence of nine VFs via PCR and for their susceptibility to 17 frequently used antibiotics using the disc diffusion method. The isolates belonged to eight different serotypes, including eight O serogroups and 12 H types. The frequency of the presence of key VFs were stx1 (76.47%), stx2 (86.27%), eae (100%), ehxA (98.03%), nleA (100%), ureC (94.11%), iha (96.07%), subA (9.80%), and saa (94.11%) in the E. coli strains. All E. coli strains carried seven or more distinct VFs and, among these, four isolates harbored all tested VFs. In addition, all E. coli strains had a high degree of antibiotic resistance and were multidrug resistant (MDR). These results show a high incidence frequency of VFs and heterogeneity of VFs and MDR profiles of E. coli strains. Moreover, half of the E. coli isolates (74.5%) were resistant to > 9 classes of antibiotics (more than 50% of the tested antibiotics). Thus, our findings highlight the importance of appropriate epidemiological and microbiological surveillance and control measures to prevent STEC disease in humans worldwide. Full article
(This article belongs to the Special Issue Discovery and Functional Evaluation of Antimicrobials)
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