Bacterial DNA Replication and Replication Inhibitors

Dear Colleagues,

This Special Issue of Antibiotics is dedicated to the topic of "Bacterial DNA Replication and Replication Inhibitors". DNA replication is a conserved and essential process in all organisms, yet significant differences exist between replication proteins of bacteria and eukaryotic cells. Following replication initiation, for most bacteria governed by the DnaA protein, replication of bacterial chromosome is carried out by a multi-protein complex called the replisome, which is present in only few copies per cell. The proteins involved in DNA replication should provide an attractive target for antimicrobial inhibition and yet only antibiotics that indirectly target the replication process are in clinical use. These inhibit the type-II topoisomerases that relieve topological stress created by DNA unwinding and decatenate daughter chromosomes prior to cell division.

This Special Issue will summarize the current knowledge on bacterial DNA replication and its inhibition by antimicrobials. It is our pleasure to invite submissions of high quality primary research manuscripts and review articles addressing the molecular mechanisms of bacterial DNA replication, its regulation and inhibition by established drugs and novel inhibitors.

Prof. Dr. Anders Løbner-Olesen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.