Antibiotic Resistance in the Water Environment

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 7816

Special Issue Editor


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Guest Editor
Department of Food, Life and Environmental Sciences, Yamagata University, Yamagata 997-8555, Japan
Interests: antibiotic resistant bacteria; water reuse; health risk assessment

Special Issue Information

Dear Colleagues,

As antibiotic-resistant bacteria (ARB) are recognized as a global threat for human health, great efforts to fight them have been made worldwide and lots of actions against ARB are ongoing in a “One-health approach” involving not only human but animal and environment health. To acceralate such actions, we need to accumulate the data and knowledge from scientific research, especially in water environments which receive effluents from human society and play a role as the sink of ARB and resistant genes (ARGs). This Special Issue aims to a showcase of the latest studies on ARB in the water environment and welcomes manuscripts concering:

  1. Prevalence of ARB and ARGs in the water environment affected by human activities such as munisicpal and industial wastewaters, animal husbandry and agriculture.
  2. Comparison of ARB and ARGs detected in the water environment between developed and developing countries.
  3. Potentials of ARB growth and ARGs transmission in the water environment.
  4. Residual antibiotics and its impact on ARB in the water environment.
  5. New technologies for research on the above topics

Prof. Dr. Toru Watanabe
Guest Editor

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Keywords

  • Antibiotic resistant bacteria
  • Antibiotic resistant genes
  • Water environment
  • Residual antibiotics
  • One health approach

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Published Papers (2 papers)

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Research

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13 pages, 1543 KiB  
Article
Monitoring Carbapenem-Resistant Enterobacterales in the Environment to Assess the Spread in the Community
by Taro Urase, Saki Goto and Mio Sato
Antibiotics 2022, 11(7), 917; https://doi.org/10.3390/antibiotics11070917 - 8 Jul 2022
Cited by 6 | Viewed by 2773
Abstract
The usefulness of wastewater-based epidemiology (WBE) was proven during the COVID-19 pandemic, and the role of environmental monitoring of emerging infectious diseases has been recognized. In this study, the prevalence of carbapenem-resistant Enterobacterales (CRE) in Japanese environmental samples was measured in the context [...] Read more.
The usefulness of wastewater-based epidemiology (WBE) was proven during the COVID-19 pandemic, and the role of environmental monitoring of emerging infectious diseases has been recognized. In this study, the prevalence of carbapenem-resistant Enterobacterales (CRE) in Japanese environmental samples was measured in the context of applying WBE to CRE. A total of 247 carbapenem-resistant isolates were obtained from wastewater, treated wastewater, and river water. Treated wastewater was shown to be an efficient target for monitoring CRE. The results of the isolate analysis showed that WBE may be applicable to Escherichia coli-carrying New Delhi metallo-β-lactamase (NDM)-type carbapenemase, the Enterobacter cloacae complex and Klebsiella pneumoniae complex-carrying IMP-type carbapenemase. In addition, a certain number of CRE isolated in this study carried Guiana extended spectrum (GES)-type carbapenemase although their clinical importance was unclear. Only a few isolates of Klebsiella aerogenes were obtained from environmental samples in spite of their frequent detection in clinical isolates. Neither the KPC-type, the oxacillinase (OXA)-type nor the VIM-type of carbapenemase was detected in the CRE, which reflected a low regional prevalence. These results indicated the expectation and the limitation of applying WBE to CRE. Full article
(This article belongs to the Special Issue Antibiotic Resistance in the Water Environment)
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Review

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19 pages, 786 KiB  
Review
Review of Antimicrobial Resistance in Wastewater in Japan: Current Challenges and Future Perspectives
by Hiroaki Baba, Masateru Nishiyama, Toru Watanabe and Hajime Kanamori
Antibiotics 2022, 11(7), 849; https://doi.org/10.3390/antibiotics11070849 - 24 Jun 2022
Cited by 13 | Viewed by 4520
Abstract
Antimicrobial resistance (AMR) circulates through humans, animals, and the environments, requiring a One Health approach. Recently, urban sewage has increasingly been suggested as a hotspot for AMR even in high-income countries (HICs), where the water sanitation and hygiene infrastructure are well-developed. To understand [...] Read more.
Antimicrobial resistance (AMR) circulates through humans, animals, and the environments, requiring a One Health approach. Recently, urban sewage has increasingly been suggested as a hotspot for AMR even in high-income countries (HICs), where the water sanitation and hygiene infrastructure are well-developed. To understand the current status of AMR in wastewater in a HIC, we reviewed the epidemiological studies on AMR in the sewage environment in Japan from the published literature. Our review showed that a wide variety of clinically important antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs), and antimicrobial residues are present in human wastewater in Japan. Their concentrations are lower than in low- and middle-income countries (LMICs) and are further reduced by sewage treatment plants (STPs) before discharge. Nevertheless, the remaining ARB and ARGs could be an important source of AMR contamination in river water. Furthermore, hospital effluence may be an important reservoir of clinically important ARB. The high concentration of antimicrobial agents commonly prescribed in Japan may contribute to the selection and dissemination of AMR within wastewater. Our review shows the importance of both monitoring for AMR and antimicrobials in human wastewater and efforts to reduce their contamination load in wastewater. Full article
(This article belongs to the Special Issue Antibiotic Resistance in the Water Environment)
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