A Themed Issue in Honor of Prof. Jae-hyuk Yu—Antimicrobial Resistance in the Foodborne Pathogens

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 1 February 2026 | Viewed by 980

Special Issue Editors


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Guest Editor
School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: aflatoxin; asexual development; staphylococcus aureus; fungal biology; antimicrobials; antibiotic resistance
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Guest Editor
School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA
Interests: microbiology; clostridioides difficile; antimicrobial discovery; mycotoxins; analytical chemistry

Special Issue Information

Dear Colleagues,

Jae-Hyuk Yu is a professor in the Department of Bacteriology at the University of Wisconsin–Madison. With over three decades of research and more than 20,000 citations, Dr. Yu is a globally recognized leader in fungal biology and food safety, holding an h-index of 60 and an i10-index of 156. He earned his B.S. in Microbiology from Seoul National University and subsequently completed his M.S. in Food Science and Ph.D. in Genetics at the University of Wisconsin–Madison. Dr. Yu’s pioneering research has elucidated key genetic mechanisms regulating fungal growth, sporulation, and toxin biosynthesis using various Aspergillus models. His work has significantly advanced our understanding of asexual and sexual development in A. nidulans, growth and pathogenesis in A. fumigatus, and the velvet regulatory complex. Additionally, he has made significant contributions to the detection, control, and detoxification of mycotoxins in food and feed. Currently, Dr. Yu’s lab is utilizing the GRAS fungus Aspergillus oryzae to combat mycotoxin contamination and to discover novel food-grade antimicrobials with potent activity against critical human and foodborne pathogens, thereby advancing both global food safety and public health.

In this Special Issue, we focus on the growing threat of antimicrobial resistance (AM) in foodborne pathogens and its implications for global health, food safety, food quality, and the stability of food supply chains. The emergence and spread of multidrug-resistant (MDR) bacteria in food products not only reduce the shelf life and quality of perishable items but also compromise public health through the potential transmission of resistant strains. Addressing these challenges requires innovative strategies that combine microbial control with effective food preservation techniques and the responsible use of food additives.

Several foodborne bacteria, including Salmonella spp., Campylobacter spp., Listeria monocytogenes, and Escherichia coli, have developed resistance to common antimicrobials and preservatives. These resistant strains reduce the effectiveness of standard antimicrobial treatments and preservatives, making it increasingly difficult to control bacterial growth and prevent contamination. Such resistance further complicates efforts to ensure food safety and prolong the shelf life of perishable foods.

This Special Issue, dedicated to Prof. Jae-Hyuk Yu, honors his remarkable contributions to microbial research and the understanding of the genomics of fungal biology, mycotoxin detoxifications, and antimicrobial discovery. It aims to highlight comprehensive studies on AMR in foodborne pathogens, including molecular characterization, epidemiology, detection methods, and novel preservation strategies. Emphasis will be placed on research that explores the role of food additives in controlling pathogen growth, as well as alternative approaches to mitigate resistance while maintaining food quality and safety.

We welcome original research articles, reviews, and case studies that address resistance mechanisms, genomic epidemiology, the effectiveness of preservation methods, and the development of innovative antimicrobials. Studies focusing on the impact of foodborne pathogens on public health and the use of preservation technologies to enhance food safety are especially encouraged.

By showcasing cutting-edge research and expert perspectives, this Special Issue aims to foster a deeper understanding of AMR in foodborne pathogens and inspire the development of effective strategies to ensure food safety and public health.

Dr. Hee-Soo Park
Dr. Ahmad Alshannaq
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • foodborne pathogens
  • antimicrobial resistance (AMR)
  • food safety
  • antimicrobial preservation
  • food additives
  • antimicrobial resistance mechanisms

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Published Papers (1 paper)

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21 pages, 1746 KB  
Article
Antimicrobial Resistance Profiles of Bacteria Isolated from the Animal Health Sector in Zambia (2020–2024): Opportunities to Strengthen Antimicrobial Resistance Surveillance and Stewardship Programs
by Taona Sinyawa, Fusya Goma, Chikwanda Chileshe, Ntombi B. Mudenda, Steward Mudenda, Amon Siame, Fred Mulako Simwinji, Mwendalubi Albert Hadunka, Bertha Chibwe, Kaunda Kaunda, Geoffrey Mainda, Bruno S. J. Phiri, Maisa Kasanga, Webrod Mufwambi, Samson Mukale, Andrew Bambala, Jimmy Hangoma, Nawa Mabuku, Benson Bowa, Obrian Kabunda, Mulumbi Nkamba, Ricky Chazya, Ruth Nakazwe, Mutila Malambo, Zoran Muhimba, Steven Mubamba, Morreah Champo, Mercy Mukuma, George Dautu, Chileshe Lukwesa, O-Tipo Shikanga, Freddie Masaninga, Mpela Chibi, Sandra Diana Mwadetsa, Theodora Savory, Joseph Yamweka Chizimu, John Bwalya Muma, Charles Maseka and Roma Chilengiadd Show full author list remove Hide full author list
Antibiotics 2025, 14(11), 1102; https://doi.org/10.3390/antibiotics14111102 - 2 Nov 2025
Viewed by 687
Abstract
Background/Objectives: Antimicrobial resistance (AMR) is a major global health threat that undermines treatment in humans and animals. In Zambia, where livestock production underpins food security and livelihoods, AMR challenges are aggravated by limited surveillance, weak diagnostics, and poor regulatory enforcement, facilitating the spread [...] Read more.
Background/Objectives: Antimicrobial resistance (AMR) is a major global health threat that undermines treatment in humans and animals. In Zambia, where livestock production underpins food security and livelihoods, AMR challenges are aggravated by limited surveillance, weak diagnostics, and poor regulatory enforcement, facilitating the spread of resistant pathogens across the human–animal–environment interface. This study aims to analyse AMR patterns of bacterial isolates collected from Zambia’s animal health sector between 2020 and 2024, to generate evidence that informs national AMR surveillance, supports antimicrobial stewardship (AMS) interventions, and strengthens One Health strategies to mitigate the spread of resistant pathogens. Methods: We conducted a retrospective descriptive analysis of previously collected routine laboratory data from five well-established animal health AMR surveillance sentinel sites between January 2020 and December 2024. Data were analysed by year, sample type, and antimicrobial susceptibility testing (AST) profiles using WHONET. Results: A total of 1688 samples were processed, with faecal samples accounting for 87.6%. Animal environmental samples (feed, manure, litter, abattoir/meat processing floor, wall, and equipment surface swabs) (collected from abattoirs, water, and farms) increased significantly over time (p = 0.027). Overall, Escherichia coli (E. coli) (50.4%) and Enterococcus spp. (30%) were the most frequently isolated bacteria. E. coli exhibited high resistance to tetracycline (74%) and ampicillin (72%) but remained susceptible to aztreonam (98%), nitrofurantoin (95%), and imipenem (93%). Enterococcus spp. were susceptible to penicillin (84%) and ampicillin (89%) but showed borderline resistance to vancomycin (53%) and linezolid (50%). Klebsiella spp. demonstrated resistance to ciprofloxacin (52%) and gentamicin (40%), whereas Salmonella spp. remained highly susceptible. Notably, resistance to amoxicillin/clavulanic acid rose sharply from 22.2% to 81.8% (p = 0.027). Across 1416 isolates, high levels of multidrug resistance (MDR) were observed, particularly in E. coli (48.4%) and K. pneumoniae (18.6%), with notable proportions progressing toward possible Extensively Drug-Resistant (XDR) and Pan-Drug-Resistant (PDR) states. Conclusions: The findings of this study reveal rising resistance to commonly used antibiotics in the animal health sector. Despite the lack of molecular analysis, our findings underscore the urgent need for AMS programs and integrated AMR surveillance under Zambia’s One Health strategy. Full article
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