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Antibiotics
Special Issues
Anti-microbial Coating Innovations to Prevent Infectious Diseases
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Anti-microbial Coating Innovations to Prevent Infectious Diseases

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: closed (1 September 2024) | Viewed by 6745

Special Issue Editors

Dr. Jinzhi Han

E-Mail Website
Guest Editor
College of Biological Science and Technology, Fuzhou University, Fuzhou, China
Interests: engineered antimicrobial peptides; antibiotic adjuvants; natural antimicrobial agents
Prof. Dr. Serena Riela

E-Mail Website
Guest Editor
Department of Chemistry, University of Catania, Via Andrea Doria, 6, 95125 Catania, Italy
Interests: organic chemistry; synthesis; drug delivery; coniugates; hallosyte nanotubes; carrier systems; nanomaterials; biocompatible materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The annual occurrence of healthcare-associated infections (HCAIs) caused by pathogens, particularly multidrug-resistant bacteria, has a significant impact on millions of patients worldwide. It poses a substantial public health risk and causes a considerable financial burden. Complementing routine hand hygiene practices, the implementation of cleaning and disinfection measures, along with the utilization of antimicrobial coatings, demonstrate promising potential in healthcare environments. Antimicrobial-coating-based approaches, which have garnered substantial commercial investment and academic research endeavors, are widely acknowledged for their potential in mitigating microbial populations on surfaces within clinical settings. This Special Issue will encompass research that harnesses innovative agents or materials and strategies for the development of antimicrobial coatings aimed at preventing infectious diseases. Papers pertaining to the development of novel agents or materials for antimicrobial coatings and the significant prevention of infectious diseases, such as antimicrobial nanomaterials, herbal-medicine-derived antimicrobial agents, antimicrobial peptides, antibiotic adjuvants, and antimicrobial hydrogel dressings, are highly encouraged.

Dr. Jinzhi Han
Prof. Dr. Serena Riela
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial nanomaterials
  • antibiotic adjuvants
  • herbal antimicrobials
  • antimicrobial peptides
  • antimicrobial hydrogel dressings

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Published Papers (2 papers)

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17 pages, 4188 KiB  
Article
Three in One with Dual-Functional Hydrogel of Lactoferrin/NZ2114/LMSH Promoting Staphylococcus aureus-Infected Wound Healing
by Kun Zhang, Xuanxuan Ma, Da Teng, Ruoyu Mao, Na Yang, Ya Hao and Jianhua Wang
Antibiotics 2024, 13(9), 889; https://doi.org/10.3390/antibiotics13090889 - 15 Sep 2024
Cited by 3 | Viewed by 2053
Abstract
Wound infections caused by Staphylococcus aureus often result in localized suppurative lesions that severely impede the healing process, so it is urgent to develop a dress with efficient antimicrobial and pro-healing functions. In this study, the bifunctional injectable hydrogel lactoferrin (Lf)/NZ2114/lithium magnesium silicate [...] Read more.
Wound infections caused by Staphylococcus aureus often result in localized suppurative lesions that severely impede the healing process, so it is urgent to develop a dress with efficient antimicrobial and pro-healing functions. In this study, the bifunctional injectable hydrogel lactoferrin (Lf)/NZ2114/lithium magnesium silicate hydrogel (LMSH) was first successfully prepared through the electrostatic interaction method. The physical, biological, and efficacy properties are systematically analyzed with good shear-thinning capacity and biocompatibility. More importantly, it inhibits infection and promotes wound healing in a mouse wound infection model after 14 d treatment, and the bactericidal rate and healing rate were over 99.92% and nearly 100%, respectively. Meanwhile, the massive reduction of inflammatory cells, restoration of tissue structure, and angiogenesis in mice showed the anti-inflammatory and pro-healing properties of the hydrogel. The healed wounds showed thickening with more hair follicles and glands, suggesting that the hydrogel Lf/NZ2114/LMSH (Three in One) could be a better dressing candidate for the treatment of S. aureus-induced wound infections. Full article
(This article belongs to the Special Issue Anti-microbial Coating Innovations to Prevent Infectious Diseases)
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27 pages, 1199 KiB  
Systematic Review
Antimicrobial Effects of Metal Coatings or Physical, Chemical Modifications of Titanium Dental Implant Surfaces for Prevention of Peri-Implantitis: A Systematic Review of In Vivo Studies
by Maria Gkioka and Xiaohui Rausch-Fan
Antibiotics 2024, 13(9), 908; https://doi.org/10.3390/antibiotics13090908 - 23 Sep 2024
Cited by 5 | Viewed by 4275
Abstract
Introduction: Peri-implantitis poses a significant challenge for implant dentistry due to its association with bacterial colonization on implant surfaces and the complexity of its management. This systematic review aims to assess evidence from in vivo studies regarding the antimicrobial efficacy of titanium (Ti) [...] Read more.
Introduction: Peri-implantitis poses a significant challenge for implant dentistry due to its association with bacterial colonization on implant surfaces and the complexity of its management. This systematic review aims to assess evidence from in vivo studies regarding the antimicrobial efficacy of titanium (Ti) dental implant surfaces following physical/chemical modifications or the application of various metal element coatings in preventing bacterial growth associated with peri-implantitis. Materials and Methods: A literature review was conducted across four scientific databases (PubMed, Embase, Scopus, Web of Science), encompassing in vivo studies published between 2013 and 2024, and 18 reports were included in the systematic review. Results: The findings suggest that titanium dental implant surfaces, following physical/chemical modifications and metal element coatings, exhibit antimicrobial effects against bacteria associated with peri-implantitis in humans and various animal models. Conclusions: The reviewed studies indicated a reduction in bacterial colonization, diminished biofilm formation, and decreased signs of inflammation in the peri-implant tissues, which provides evidence that physical/chemical alterations on titanium dental implant surfaces or metal element coatings, like silver (Ag), zinc (Zn), magnesium (Mg), and copper (Cu), demonstrate antimicrobial properties in in vivo studies. However, caution is warranted when translating findings to clinical practice due to methodological disparities and high bias risks. Further larger-scale clinical trials are imperative to assess their long-term efficacy and validate their clinical applicability. Full article
(This article belongs to the Special Issue Anti-microbial Coating Innovations to Prevent Infectious Diseases)
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