Metabolic Regulation of Animal Reproduction: Ovarian Mechanisms and Breeding Applications

Dear Colleagues,

As the central organ of the female reproductive system, the ovary is subject to precise, dynamic regulation by the animal’s systematic and local metabolic status. Recently, rapid advances in interdisciplinary fields such as epigenetics, metabolomics and intercellular communication networks have illuminated how nutrition, systemic and local metabolism, and endocrine disruptors influence ovarian function. Consequently, the intersection of metabolism and ovarian physiology has emerged as a cutting-edge frontier in animal reproductive biology.

This Special Issue aims to systematically integrate the latest research progress on metabolic regulation and ovarian physiology, including but not limited to the following: (1) Regulatory mechanisms by which material metabolism, endocrine disruptors and nutritional signaling govern ovarian development. (2) Molecular and functional consequences of metabolic disorders such as stress, obesity and negative energy balance on reproductive performance. (3) The mediating role of epigenetic modifications in the metabolism–ovary axis. (4) Innovative, application-oriented strategies leveraging metabolic regulation to enhance reproductive efficiency in livestock.

We invite original research articles and review papers across reproductive physiology, nutritional regulation, and veterinary translational research. Together, these contributions will advance both fundamental understanding and practical implementation in the field of metabolic regulation of animal reproduction.

Prof. Dr. Dagan Mao
Guest Editor

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