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Drugs and Drug Candidates, Volume 3, Issue 1

March 2024 - 17 articles

Cover Story: Drug discovery entails four stages: target identification, compound screening, lead optimization, and preclinical/clinical trials. Initial steps employ bioinformatics and genomics to pinpoint pathophysiological factors and targets. Hits from chemical libraries or natural products are screened for activity against targets. Lead molecules undergo optimization for specificity and efficacy. Cell assays and structure–activity relationships refine candidate properties. Animal models assess in vivo effects, while clinical trials validate drug efficacy and patient safety. However, the process is time-consuming and costly. Therefore, pharmaceutical companies are turning to artificial intelligence to expedite and streamline drug discovery. AI aids in cell sorting, compound property prediction, organic synthesis, and other tasks, enhancing efficiency and productivity. View this paper
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Articles (17)

  • Article
  • Open Access
2 Citations
3,161 Views
20 Pages
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DFT Calculations, Pro-Apoptotic Effects, and Anti-Infective Investigations of Alkaloids Isolated from the Stem Bark Extract of Enantia chlorantha

  • Vincent O. Imieje,
  • Ahmed A. Zaki,
  • Mansour A. E. Bashar,
  • Islam Rady,
  • Mohamed A. M. El-Tabakh,
  • Mohamed A. E. Abd El-Aziz,
  • Eman. S. Abou-Amra,
  • Shahd Yasser,
  • Ibraheem M. M. Gobaara and
  • Mohammed A. S. Abourehab
  • + 3 authors
Drugs Drug Candidates2024, 3(1), 291-310;https://doi.org/10.3390/ddc3010017

7 March 2024

Fractionation of the stem bark of Enantia chlorantha Oliv yields three alkaloids, palmatine (1), jatrorrhizine (2), columbamine (3), and β-Sitosterol (4). In this investigation, density functional theory (DFT) calculations were carried out to ev...

Full Article
  • Article
  • Open Access
3 Citations
3,007 Views
16 Pages
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Development of Paclitaxel Proliposomal Dry Powder Inhaler (PTX-PLM-DPI) by Freeze-Drying Method for Lung Cancer

  • Chinmoyee Borah,
  • Trideep Saikia,
  • Alakesh Bharali,
  • Madhuchandra Lahan,
  • Nikhil Biswas and
  • Bhanu P Sahu
Drugs Drug Candidates2024, 3(1), 275-290;https://doi.org/10.3390/ddc3010016

5 March 2024

Despite various efforts, a successful selective delivery system for chemotherapeutic agents for lung cancer is still lacking. Dry powder inhaler (DPI) systems based on proliposomes (PLMs) could be a potential system for the efficient delivery of pacl...

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  • Article
  • Open Access
2 Citations
2,940 Views
19 Pages
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Anti-Shigellosis Activity and Mechanisms of Action of Extracts from Diospyros gilletii Stem Bark

  • Audrey Carrel Nguelo Talla,
  • Eugénie Aimée Madiesse Kemgne,
  • Vincent Ngouana,
  • Bijou-Lafortune Noumboue Kouamou,
  • Listone Monelle Nzeye Ngameni,
  • Brice Rostan Pinlap,
  • Yanick Kevin Dongmo Melogmo,
  • Branly-Natalien Nguena-Dongue,
  • Boniface Pone Kamdem and
  • Paul Keilah Lunga
  • + 1 author
Drugs Drug Candidates2024, 3(1), 256-274;https://doi.org/10.3390/ddc3010015

1 March 2024

Shigellosis is a pathological condition that affects the digestive system and possibly causes diarrhoea. Shigella species, which are responsible for this disease, are highly contagious and spread through contaminated food and water. The increasing de...

Full Article
  • Article
  • Open Access
2,285 Views
12 Pages
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Susceptibility Patterns in Staphylococcus and Klebsiella Causing Nosocomial Infections upon Treatment with E-Anethole-Rich Essential Oil from Clausena anisata

  • François Nguimatsia,
  • Evariste Josué Momo,
  • Paul Keilah Lunga,
  • Virginia Lum Tamanji,
  • Boniface Pone Kamdem and
  • Pierre Michel Jazet Dongmo
Drugs Drug Candidates2024, 3(1), 244-255;https://doi.org/10.3390/ddc3010014

1 March 2024

High rates of resistance to antibiotics are associated with healthcare-related infections, thus demonstrating the urgent need for effective antimicrobials against these maladies. The present study aims to determine the chemical composition of essenti...

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  • Conference Report
  • Open Access
2,399 Views
35 Pages
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31st Annual GP2A Medicinal Chemistry Conference

  • Nicolas Primas,
  • Caroline Castera-Ducros,
  • Romain Paoli-Lombardo,
  • Christophe Curti,
  • Fanny Mathias,
  • Pascal Rathelot,
  • Pascal Marchand and
  • Patrice Vanelle
Drugs Drug Candidates2024, 3(1), 209-243;https://doi.org/10.3390/ddc3010013

22 February 2024

The Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A) held its 31st annual conference in August 2023 at the Faculty of Pharmacy of Aix-Marseille University, Marseille, France. There were 8 keynote presentations, 10 early career r...

Full Article
  • Review
  • Open Access
488 Citations
135,430 Views
24 Pages
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Plant-Derived Natural Products: A Source for Drug Discovery and Development

  • Noureddine Chaachouay and
  • Lahcen Zidane
Drugs Drug Candidates2024, 3(1), 184-207;https://doi.org/10.3390/ddc3010011

19 February 2024

For thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins. Plants have long been used as folk herbal medicines to treat various disorders, and...

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  • Article
  • Open Access
1 Citations
2,546 Views
12 Pages
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Isolation and Characterization of Antimicrobial Constituent(s) from the Stem of Cissus populnea Guill. & Perr.

  • Anita Alex-Asaolu,
  • Ahmad Uba,
  • Umar Abubakar Birnin-Yauri and
  • Amina Jega Yusuf
Drugs Drug Candidates2024, 3(1), 172-183;https://doi.org/10.3390/ddc3010010

19 February 2024

Cissus populnea Guill. & Perr. (Vitaceae) is used in traditional medicine to treat microbial infections, venereal diseases and infertility, among others. The aim of this research is to isolate and characterize the antimicrobial constituent(s) fro...

Full Article
  • Review
  • Open Access
44 Citations
24,844 Views
24 Pages
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Revolutionizing Drug Discovery: A Comprehensive Review of AI Applications

  • Rushikesh Dhudum,
  • Ankit Ganeshpurkar and
  • Atmaram Pawar
Drugs Drug Candidates2024, 3(1), 148-171;https://doi.org/10.3390/ddc3010009

13 February 2024

The drug discovery and development process is very lengthy, highly expensive, and extremely complex in nature. Considering the time and cost constraints associated with conventional drug discovery, new methods must be found to enhance the declining e...

Full Article
  • Review
  • Open Access
2 Citations
12,294 Views
22 Pages
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Beta-Thalassemia: A Pharmacological Drug-Based Treatment

  • Shrabonti Biswas,
  • Shanita Zaman Smrity,
  • Md. Shimul Bhuia,
  • Fatema Akter Sonia,
  • Mst. Asma Aktar,
  • Raihan Chowdhury,
  • Tawhida Islam,
  • Muhammad Torequl Islam,
  • Gabriel Gonçalves Alencar and
  • Cicera Laura Roque Paulo
  • + 2 authors
Drugs Drug Candidates2024, 3(1), 126-147;https://doi.org/10.3390/ddc3010008

8 February 2024

This review was performed to determine the potential of drugs that can remove or decrease the requirements for blood transfusion among beta (β)-thalassemia patients. A comprehensive literature search was conducted to identify clinical trials and...

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