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Drugs and Drug Candidates, Volume 3, Issue 1

March 2024 - 17 articles

Cover Story: Drug discovery entails four stages: target identification, compound screening, lead optimization, and preclinical/clinical trials. Initial steps employ bioinformatics and genomics to pinpoint pathophysiological factors and targets. Hits from chemical libraries or natural products are screened for activity against targets. Lead molecules undergo optimization for specificity and efficacy. Cell assays and structure–activity relationships refine candidate properties. Animal models assess in vivo effects, while clinical trials validate drug efficacy and patient safety. However, the process is time-consuming and costly. Therefore, pharmaceutical companies are turning to artificial intelligence to expedite and streamline drug discovery. AI aids in cell sorting, compound property prediction, organic synthesis, and other tasks, enhancing efficiency and productivity. View this paper
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Articles (17)

  • Review
  • Open Access
5 Citations
5,778 Views
24 Pages

Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia

  • Iván Alquisiras-Burgos,
  • Irma Gabriela González-Herrera,
  • Sergio Alcalá-Alcalá and
  • Penélope Aguilera

26 January 2024

Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the pr...

  • Review
  • Open Access
5 Citations
3,270 Views
32 Pages

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

  • Tapas Kumar Mohapatra,
  • Reena Rani Nayak,
  • Ankit Ganeshpurkar,
  • Prashant Tiwari and
  • Dileep Kumar

18 January 2024

Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action. Universally, this has boosted the re...

  • Review
  • Open Access
1 Citations
2,813 Views
16 Pages

COVID-19 has claimed around 7 million lives (from December 2019–November 2023) worldwide and continues to impact global health. SARS-CoV-2, the virus causing COVID-19 disease, is characterized by a high rate of mutations, which contributes to i...

  • Article
  • Open Access
1 Citations
1,809 Views
19 Pages

Total Synthesis and Anti-HIV Activity Evaluation of Desmosdumotin D and Analogues

  • Ying Deng,
  • Xiaoping Song,
  • Tongtong Yun,
  • Zuo Xiang,
  • Guanghui Wang,
  • Gang Li,
  • Yanxin Zhang,
  • Yiming Song and
  • Qingchao Liu

The natural product Desmosdumotin D (hereafter referred to as Des-D), isolated from the plant Desmos dumosus, showed potent anti-HIV activity. However, the subsequent pharmacological activity and clinical studies are limited due to the low content of...

  • Article
  • Open Access
1 Citations
2,446 Views
20 Pages

Biological Synthesis and Characterization of Silver-Doped Nanocomposites: Antibacterial and Mechanistic Studies

  • Franklin Loic Tchinda Taghu,
  • Boniface Pone Kamdem,
  • Vincent Ngouana,
  • Zuriatou Yajeh Tanka,
  • Victorine Lorette Yimgang,
  • Julius Nsami Ndi,
  • Paul Keilah Lunga and
  • Fabrice Fekam Boyom

26 December 2023

The development of antimicrobial resistance has increased the prevalence of infectious diseases, causing a global health problem that accounts for over 4.95 million deaths worldwide annually. The side effects associated with current antibiotics promp...

  • Article
  • Open Access
2 Citations
1,971 Views
12 Pages

Modulatory Effect of Croton heliotropiifolius Kunth Ethanolic Extract on Norfloxacin Resistance in Staphylococcus aureus

  • Samara Barbosa de Brito,
  • Felipe Araújo de Oliveira Alcântara,
  • Antonio Linkoln Alves Borges Leal,
  • Kaliny Henri da Silva Veloso,
  • Leonardo da Rocha Sousa,
  • Ana Paula de Oliveira,
  • Alan Diego da Conceição Santos,
  • Lívia Macedo Dutra,
  • Jackson Roberto Guedes da Silva Almeida and
  • Carlos Emídio Sampaio Nogueira
  • + 4 authors

The high frequency of infectious diseases has spurred research into effective tactics to combat microorganisms that are resistant to several drugs. The overproduction of the transmembrane efflux pump protein NorA, which may export hydrophilic fluoroq...

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Drugs Drug Candidates - ISSN 2813-2998