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Biologics, Volume 6, Issue 3

2026 September - 8 articles

Cover Story: Exosomes and NLRP3 signaling overlap at many levels of cell organization. NLRP3 promotes exosome biogenesis and secretion through the intracellular trafficking remodeling and redistribution of multivesicular bodies. These processes influence the exosomal cargo, through mechanisms involving RNA-binding proteins and the endosomal sorting machinery. Conversely, exosomes modulate NLRP3 activity in recipient cells by delivering regulatory molecules affecting NLRP3 signaling. Though exosome release is increased in inflammatory disorders, the relationship between exosome pathways and NLRP3 remains poorly understood. We review evidence connecting NLRP3 activation to extracellular vesicle trafficking, exosome formation, and cargo selection, and discuss how exosome-mediated communication shapes inflammasome signaling across cells and tissues. View this paper
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Articles (8)

  • Article
  • Open Access
454 Views
21 Pages

Anticancer and Antibacterial Activities of Eucalyptus camaldulensis

  • Achwaa Chbib,
  • Malak Mezher,
  • Mohamad Nasser,
  • Akram Hijazi and
  • Mahmoud I. Khalil

15 September 2026

Background/Objectives: Conventional cancer treatments such as radiation therapy, chemotherapy, and surgery often severely reduce a patient’s quality of life due to their side effects. This underscores the urgent need to develop less toxic and m...

  • Review
  • Open Access
758 Views
20 Pages

Exosomes and the NLRP3 Inflammasome: A Bidirectional Axis in Cellular Signaling and Vesicle Trafficking in Health and Disease

  • Rossana Franzin,
  • Luigi Malaspina,
  • Anna Storelli,
  • Monica Campioni and ,
  • Gabriele Ruggieri,
  • Francesca Celiberto,
  • Fabio Sallustio,
  • Anna Gallone,
  • Loreto Gesualdo and
  • Paola Pontrelli
  • + 5 authors+ 0 author

10 September 2026

Exosomes are small extracellular vesicles (EVs) generated through the endosomal pathway that mediate intercellular communication by transferring proteins, lipids, and regulatory RNAs. In parallel, the NLRP3 inflammasome is a key signaling platform of...

  • Article
  • Open Access
859 Views
15 Pages

Longitudinal FIB-4 and APRI Monitoring in Psoriatic Arthritis: Associations with Cumulative Methotrexate Exposure and Biologic Therapy Class

  • Mehmet Serkan Kılıçoğlu,
  • Safa El Mardi Alaoui,
  • Ozan Volkan Yurdakul,
  • Ayşegül Yabacı Tak and
  • Teoman Aydın

Background: Psoriatic arthritis (PsA) is associated with hepatic risk, but longitudinal data during methotrexate (MTX) and biologic therapy are limited. We evaluated two-year changes in age-fixed FIB-4 and APRI and their associations with cumulative...

  • Review
  • Open Access
2,175 Views
15 Pages

Stem Cell-Based Regenerative Therapy for Genitourinary Syndrome of Menopause (GSM): Current Evidence and Future Perspectives

  • Khanisyah Erza Gumilar,
  • Riska Wahyuningtyas,
  • Ching-Pei Tsai,
  • Nurul Hikmah Mat Noh and ,
  • Anggi Wilis Prihazty,
  • Cornelia Valerie Genika Loveita Sugoro,
  • Eighty Mardiyan Kurniawati and
  • Fedik Abdul Rantam
  • + 3 authors+ 0 author

Genitourinary syndrome of menopause (GSM) is a common hypoestrogenic condition marked by vulvovaginal atrophy and lower urinary tract symptoms that significantly impair quality of life in peri- and postmenopausal women. Although local estrogen therap...

(This article belongs to the Section Protein Therapeutics)
  • Article
  • Open Access
542 Views
23 Pages

Effects of a Nasal Spray Based on an Antigen Complex from Opportunistic Bacteria in Experimental Models of SARS-CoV-2 and Influenza A Infection

  • Nikita Sidorov,
  • Alena Soldatenkova,
  • Stanislav Kedik,
  • Natalia Michailova and ,
  • Elvira Kudryavtseva,
  • Elena Afanasyeva,
  • Alexey Panov and
  • Vladimir Gureev
  • + 3 authors+ 0 author

Background/Objectives: Acute respiratory infections represent a global health burden due to their high incidence, morbidity and mortality. Despite advances in prevention and treatment, strategies providing broad protection against respiratory pathoge...

  • Review
  • Open Access
1,875 Views
30 Pages

The tooth is a complex biological organ composed of multiple tissues, including enamel, dentine, cementum and pulp. However, dental disease and tooth loss due to periodontitis, caries, or trauma adversely affect most adults at some time in their live...

  • Article
  • Open Access
717 Views
20 Pages

Backgrounds/Objectives: Probiotics confer health-promoting and immunomodulatory effects on the host. However, a lot remains to be understood regarding their safety profile, characteristics and functional mechanisms. This study was conducted to compre...

  • Article
  • Open Access
1,247 Views
16 Pages

Dose-Limiting Cytopenias Associated with Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer: An Institutional Review

  • Evan Adler,
  • Krishna Gandhi,
  • Debamita Kundu,
  • Paul Viscuse and ,
  • Jack Masur,
  • Michael Devitt,
  • Robert Dreicer and
  • William Paul Skelton
  • + 3 authors+ 0 author

Background: Despite the therapeutic advances made in castration-sensitive prostate cancer, progression to castration-resistant disease is inevitable. Lutetium-177 vipivotide tetraxetan (177Lu-PSMA-617) is a novel radioligand approved for use in metas...

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Biologics - ISSN 2673-8449