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Biologics, Volume 6, Issue 4

2026 December - 5 articles

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Articles (5)

  • Article
  • Open Access
182 Views
15 Pages

GMP-Compliant Manufacturing of Human BM-MSC Secretome for Clinical Investigation as a Topical Eye Drop

  • Zohreh Arabpour,
  • Seungwon An,
  • Soheil Sojdeh,
  • Zahra Bibak Bejandi and ,
  • Khandaker N. Anwar,
  • Mohammad Soleimani,
  • Mahmood Ghassemi,
  • Nadim Mahmud and
  • Ali R. Djalilian
  • + 4 authors+ 0 author

30 October 2026

Background: Bone marrow-derived mesenchymal stromal cell (BM-MSC) secretome is a promising cell-free therapeutic approach for tissue regeneration. However, clinical translation requires scalable manufacturing processes, rigorous quality control, and...

  • Review
  • Open Access
121 Views
21 Pages

Emerging Biologics in Neuroendovascular Management: From Periprocedural Pharmacotherapy to Regenerative and Gene-Based Interventions

  • Sardar Umer Irshad,
  • Maya Haghighi,
  • Clayton Rawson,
  • Andrea Baloi and ,
  • Shah Mir,
  • Mehrdad Pahlevani and
  • Brandon Lucke-Wold
  • + 2 authors+ 0 author

27 October 2026

Neuroendovascular medicine is moving beyond purely mechanical treatment toward catheter-based systems that also deliver biologic therapies. In this narrative review, “biologic-enabled neurointervention” denotes three groups, distinguished...

  • Article
  • Open Access
184 Views
21 Pages

Therapeutic Trajectories, Drug Survival, and Adverse Events in Patients with Difficult-to-Treat Rheumatoid Arthritis in Real-World Clinical Practice

  • Alena I. Zagrebneva,
  • Elena N. Simonova,
  • Yuliya A. Gavrikova,
  • Vladislav V. Dolgov and ,
  • Anastasiia A. Buianova and
  • Vadim I. Mazurov
  • + 1 author+ 0 author

23 October 2026

Background/Objectives: Difficult-to-treat rheumatoid arthritis (D2T-RA) affects approximately 11.7% of patients. Real-world data on treatment trajectories, biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), and advers...

  • Article
  • Open Access
298 Views
16 Pages

Variation of the Dose of Norepinephrine in Septic Shock Patients Treated with an IgM- and IgA-Enriched Immunoglobulin Preparation: Secondary Analysis of a Prospective Multicenter Observational Study

  • Mattia Bixio,
  • Alice Scamperle,
  • Giada Quarantotto,
  • Silvia Zanchi and ,
  • Silvia Baronio,
  • Lucia Mirabella,
  • Alessandro Conti,
  • Francesco Forfori,
  • Alberto Noto and
  • Giorgio Berlot
  • + 12 authors+ 7 authors

30 September 2026

Background/Objectives: The role of intravenous immunoglobulins (eIg) in septic shock remains controversial, and the identification of patients most likely to benefit from therapy is still uncertain. Emerging evidence suggests that dynamic parameters...

(This article belongs to the Topic Advances in Vaccines and Antimicrobial Therapy—2nd Edition)
  • Review
  • Open Access
477 Views
22 Pages

Extracellular Vesicles in Ocular Surface and Anterior Segment Medicine: Biological Roles, Therapeutic Applications, and Diagnostic Potential

  • Tomohiro Yasutake,
  • Kimiko Tano,
  • Saya Oya,
  • Ayumi Oka and ,
  • Tomoko Tsukahara-Kawamura and
  • Masatoshi Hirayama
  • + 1 author+ 0 author

28 September 2026

Extracellular vesicles (EVs) are increasingly recognized as mediators of intercellular communication and as potential therapeutic and diagnostic platforms. In the ocular surface and anterior segment, EVs are released by epithelial, stromal, endotheli...

(This article belongs to the Section Cytokines and Allied Mediators)
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Biologics - ISSN 2673-8449