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  • Article
  • Open Access
444 Views
12 Pages

Risk of Developing Clostridioides Difficile Infection with the Use of Proton Pump Inhibitors in Patients with Inflammatory Bowel Disease

  • Mustafa Gandhi,
  • Harleen Kaur Chela,
  • Maxwell A. Barffour,
  • Emily Bosak,
  • Emily Reznicek,
  • Kevin Luton,
  • Matthew Bechtold and
  • Yezaz A. Ghouri

1 December 2025

Introduction: Patients with inflammatory bowel disease (IBD) have an increased risk of Clostridioides difficile infection (CDI). While antibiotic exposure has been considered the most prominent risk factor for CDI, proton pump inhibitor (PPI) use is...

  • Review
  • Open Access
599 Views
15 Pages

Mesenchymal Stem Cells and Their Derivatives: Old Problems and New Possibilities in Regenerative Medicine for Neurological Diseases

  • Elvira Akhmetzyanova,
  • Ilya Shulman,
  • Taisiya Fakhrutdinova,
  • Albert Rizvanov and
  • Yana Mukhamedshina

28 November 2025

Mesenchymal stem cells are multipotent stromal cells with immunomodulatory, anti-inflammatory, and trophic properties that support tissue repair and regeneration. Increasing evidence suggests that their therapeutic effects are primarily mediated by p...

  • Review
  • Open Access
1,041 Views
21 Pages

10 November 2025

Lyophilization (freeze-drying) has become a cornerstone pharmaceutical technology for stabilizing biopharmaceuticals, overcoming the inherent instability of biologics, vaccines, and complex drug formulations in aqueous environments. The appropriate l...

  • Article
  • Open Access
499 Views
20 Pages

3 November 2025

Background: Various thiolactones are known as biologically active compounds, capable of stimulating the development of several human diseases and quorum sensing of Gram–positive bacteria. The enzymatic hydrolysis of thiolactones represents a pr...

  • Article
  • Open Access
1,454 Views
11 Pages

22 October 2025

Background/Objectives: Omalizumab is a monoclonal anti-IgE antibody approved for the treatment of chronic urticaria. There are no established or validated prognostic markers currently available to identify likely responders. The aim of this study was...

  • Article
  • Open Access
739 Views
25 Pages

13 October 2025

Background/Objectives: Obesity increases reactive oxygen species (ROS), thereby triggering oxidative stress. Coriander seeds contain polyphenolic compounds that act as natural antioxidants to reduce oxidative stress. Coriander seed ethanolic extract...

  • Article
  • Open Access
1,292 Views
15 Pages

11 October 2025

Background/Objectives: Sera from patients before and after organ transplantation were tested at two different temperatures, 21 °C and 37 °C. Currently, organs are transported under normothermic conditions (37 °C). This observational pilot...

  • Case Report
  • Open Access
634 Views
7 Pages

Rituximab-Associated Myocardial Injury in a Young Woman with Granulomatosis with Polyangiitis: A Case Report

  • Natasha E. Barton,
  • Elizabeth A. Stein,
  • Kathryn Mulvaney and
  • Yevgeniya Scherbak

10 October 2025

Background: Rituximab is a monoclonal antibody targeting CD20, commonly used to treat autoimmune diseases such as granulomatosis with polyangiitis (GPA) and rheumatoid arthritis. While generally well-tolerated, serious adverse events, including infus...

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Biologics - ISSN 2673-8449