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BioChem, Volume 6, Issue 2

2026 June - 6 articles

Cover Story: Voltage-gated sodium channel Nav1.7 plays a central role in electrical signaling and is a major therapeutic target for pain disorders. In this study, we present a reproducible computational framework to identify and classify sodium ion hydration–coordination microstates within the Nav1.7 pore using molecular dynamics simulations. Sodium ions were categorized into water-only, mixed protein–water, and protein-only coordination environments, revealing chemically distinct microstates that cannot be described by hydration number alone. The workflow provides representative quantum-ready structures that can be used in future density functional theory, QM/MM, and quantum computing studies to investigate ion–protein interactions in biologically relevant confined environments. View this paper
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Articles (6)

  • Article
  • Open Access
576 Views
13 Pages

17 June 2026

Voltage-gated sodium channels are central to electrical excitability, and Nav1.7 is a major therapeutic target implicated in pain disorders and sensory signaling. Within the channel pore, permeating Na+ ions experience dynamically fluctuating hydrati...

  • Article
  • Open Access
1,500 Views
18 Pages

This study addresses two key challenges in computational pharmacology: identifying novel therapeutic uses for existing drugs and modeling drug safety-related characteristics. We propose a multi-relational biomedical knowledge graph that integrates ge...

  • Article
  • Open Access
1 Citations
791 Views
17 Pages

To improve the visible-light response and antibacterial performance of titanium dioxide, a TiO2/GO/CdS mesoporous nanocomposite was prepared via an ultrasound-assisted sol–gel method in this study. Systematic characterizations including XRD, XP...

(This article belongs to the Special Issue Biochemistry in Microbe–Microbe Interactions)
  • Article
  • Open Access
701 Views
12 Pages

Association of ACE I/D and TNF-α-308 Polymorphisms with COVID-19 Severity in a Mexican Population

  • Mayela del Ángel-Martínez,
  • Mauricio Salinas-Santander,
  • Michelle Giovanna Santoyo-Suárez,
  • Lesly González-Flores,
  • Omar Reyes-Torres and
  • Antonio Morlett-Chávez

Background: COVID-19 severity shows marked interindividual variability, suggesting a role for host genetic factors. Polymorphisms in genes involved in the renin–angiotensin system and inflammatory response, such as the angiotensin-converting en...

  • Review
  • Open Access
1 Citations
2,569 Views
12 Pages

29 April 2026

Background: D-amino acids are increasingly recognized as bioactive molecules with diverse physiological and pathological roles in humans, particularly in the gut, kidneys, and nervous system. Advances in analytical techniques have revealed their wide...

  • Editorial
  • Open Access
888 Views
8 Pages

Feature Papers in BioChem, 2nd Edition

  • Manuel Aureliano and
  • Buyong Ma

27 March 2026

As mentioned in the Editorial of the first edition of the Special Issue on “Feature Papers in BioChem”, biochemistry acts as a key cog in the “clock of the knowledge, permitting that wheels from several science areas move each other...

(This article belongs to the Special Issue Feature Papers in BioChem, 2nd Edition)
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BioChem - ISSN 2673-6411