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Immuno, Volume 4, Issue 2

2024 June - 4 articles

Cover Story: Resveratrol and its derivative piceid exhibit a wide spectrum of health-promoting bioactivities. Resveratrol-enriched rice, DJ526, has been developed by transfection of a resveratrol biosynthesis gene. These resveratrol-enriched seeds were induced to callus. Callus extract contained greater amounts of resveratrol and piceid than DJ526 seeds, and treatment with DJ526 callus extract significantly reduced the LPS-induced production of proinflammatory mediators. The inflammation-related NF-κB and MAPK pathways were also inhibited in DJ526-callus-extract-treated RAW264.7 cells, resulting in downregulation of proinflammatory factor genes. These finding demonstrate increased resveratrol and piceid content by callus culture of DJ526 rice seeds and the potent anti-inflammatory activity of resveratrol-enriched callus extract. View this paper

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Article

2,872 Views

14 Pages

Synergistic Effect of Co-Administered SARS-CoV-2 Vaccines Improves Immune Responses in BALB/c Mice: A Preliminary Study

Nshimirimana Jonas,
Josephine Kimani,
James Kimotho,
Matthew Mutinda Munyao and
Samson Muuo Nzou

Immuno2024, 4(2), 172-185;https://doi.org/10.3390/immuno4020012

7 June 2024

Various vaccine platforms have been approved for broad use to prevent the transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, these vaccines exhibit distinct differences in immunogenicity and efficacy, whi...

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Article

2 Citations

3,054 Views

13 Pages

Rosuvastatin Intervention in Patients with Chronic Hepatitis B (CHB) Expands CD14+ CD16− Classical Monocytes via Aryl Hydrocarbon Receptor (AHR)

Mina Rahmati,
Mojtaba Zare Ebrahimabad,
Alale Langari,
Ali Najafi,
Shohreh Taziki,
Alireza Norouzi,
Mehrdad Teimoorian,
Milad Khorasani and
Saeed Mohammadi

Immuno2024, 4(2), 159-171;https://doi.org/10.3390/immuno4020011

17 May 2024

Chronic hepatitis B (CHB) poses treatment challenges, with treatment response and disease outcome often determined by the immune response, particularly mononuclear phagocytes. Monocytes can differentiate into various subpopulations influenced by AHR....

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Systematic Review

6 Citations

4,375 Views

12 Pages

Systematic Review: JAK-STAT Regulation and Its Impact on Inflammation Response in ARDS from COVID-19

Irasema Rodriguez and
Kate J. F. Carnevale

Immuno2024, 4(2), 147-158;https://doi.org/10.3390/immuno4020010

14 May 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has had a global impact and resulted in millions of deaths worldwide. The course of the Janus kinase signaling transducers and activators (JAK-STAT) pathway is an important molecu...

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Article

4 Citations

3,453 Views

16 Pages

Anti-Inflammatory Efficacy of Resveratrol-Enriched Rice Callus Extract on Lipopolysaccharide-Stimulated RAW264.7 Macrophages

Chaiwat Monmai,
Jin-Suk Kim and
So-Hyeon Baek

Immuno2024, 4(2), 131-146;https://doi.org/10.3390/immuno4020009

3 April 2024

Resveratrol and its derivative piceid exhibit a wide spectrum of health-promoting bioactivities. A resveratrol-enriched variety of Dongjin rice (DJ526) has been developed by transfection of a resveratrol biosynthesis gene, and increased resveratrol c...

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