2026 December - 11 articles
Background/Objectives: Oligodendrocyte maturation and function are stimulated by insulin and insulin-like growth factor (IGF) signaling through Akt-mTOR and Notch. Dysregulation of these pathways is associated with impaired white matter development;...
Satellite glial cells (SGCs) are specialized glial cells found in peripheral ganglia, including the dorsal root ganglia (DRG), where they tightly envelop sensory neuronal somata. Through this intimate bidirectional communication, SGCs actively regula...
Vascular contributions to cognitive impairment and dementia (VCID) have emerged as critical determinants of age-related cognitive decline, yet they remain insufficiently recognized in both clinical practice and research. This comprehensive review syn...
Experience-dependent plasticity involves coordinated changes in neuronal and glial function, but the glial contribution to circuit adaptation in autism spectrum disorder (ASD) remains incompletely understood. Astrocytes monitor synaptic activity and...
Background/Objectives: Glioblastoma (GBM) is a highly aggressive brain tumor characterized by marked heterogeneity, therapy resistance, and poor prognosis. Dysregulation of autophagy and apoptosis may contribute to tumor adaptation, yet experimental...
Background/Objectives: Interindividual variability in responses to physiological and pathological perturbations remains a fundamental challenge in neuroscience. Astrocytes and microglia are dynamic regulators of brain homeostasis, immune surveillance...
Background: Interleukin-13 Receptor alpha 2 (IL13Rα2) is an attractive therapeutic target for glioblastoma because of its limited expression in normal brain tissue and overexpression in many tumors. However, the spatial heterogeneity of gliobla...
The cerebellum, long studied as the principal center for motor coordination, is now recognized as a participant in epileptogenic network dynamics through the pathway running from the cerebellar cortex to the deep cerebellar nuclei and on to thalamic...
Background: Mood disorders are associated with excess mortality and with cardiovascular, oncological, endocrine and gastrointestinal disease, yet the mechanisms that link the brain and the body remain unclear. Small extracellular vesicles (sEVs) cros...
Background/Objective: New therapeutic targets are urgently needed for glioblastoma, the most aggressive primary brain tumor in adults. Monepantel (MPL), a repurposed anthelmintic, is thought to act in cancer cells through ATF4-mediated endoplasmic re...
Brain aging is characterized by heterogeneous microglial states and altered mitochondrial, metabolic, and lysosomal homeostasis. Mitophagy is central to mitochondrial quality control, but its contribution to age-associated microglial dysfunction rema...
