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Journal of Composites Science, Volume 6, Issue 11
November 2022 - 31 articles
Cover Story: The natural extracellular matrix (ECM) is highly heterogeneous and anisotropic due to the existence of biomacromolecule bundles and pores. Biomimetic hierarchical nanocomposite hydrogels have emerged as potential candidates to better recapitulate natural ECM by introducing various nanostructures, such as nanoparticles, nanorods, and nanofibers. Moreover, the nanostructures in nanocomposite hydrogels can be engineered as stimuli-responsive actuators to realize the desirable control of hydrogel properties, thereby manipulating the behaviors of the encapsulated cells upon appropriate external stimuli. We present a comprehensive summary of the main strategies to construct biomimetic hierarchical nanocomposite hydrogels with emphasis on the rational design of local hydrogel properties and their recent development and challenges in biomedical applications. View this paper
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J. Compos. Sci. - ISSN 2504-477X