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Tomography, Volume 12, Issue 7

2026 July - 17 articles

Cover Story: Space exploration exposes astronauts to a unique radiation environment dominated by galactic cosmic rays and solar particle events, raising concerns about long-term cancer risk during extended missions beyond low-Earth orbit. This review examines current evidence on space radiation carcinogenesis, available risk-prediction models, and the major uncertainties related to dose estimation, radiation quality, and individual susceptibility. Particular attention is given to emerging imaging approaches and their potential role in monitoring radiation-induced biological effects and supporting personalized risk assessment. A better understanding of these mechanisms will be essential for protecting astronauts’ health during future missions to the Moon, Mars, and beyond. View this paper
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Articles (17)

  • Article
  • Open Access
564 Views
14 Pages

Ocular Radiation Exposure and Shielding Practices During Complex Fluoroscopic Guided Interventions: An Exploratory Multicenter Observational Study

  • Mathias Grau,
  • Osama Eldergash,
  • Sandeep Sunder Amin,
  • Martin H. Maurer,
  • Matteo Haupt,
  • Vivek Chopda,
  • Björn Poppe,
  • Bernhard Schmuck,
  • Arne Schwindt and
  • Christian Mathys
  • + 4 authors

Background/Objectives: Lead acrylic shields (LASs) enhance radiation protection, with variation of their usage among different specialties. This prospective multicentric observational study aimed to explore patterns of ocular radiation exposure and L...

(This article belongs to the Special Issue Imaging in Vascular Interventional Radiology)
  • Review
  • Open Access
804 Views
18 Pages

Space Radiation and Cancer Risk in Astronauts: Models, Evidence, Uncertainties, and Emerging Imaging Perspectives

  • Chiara Zanon,
  • Michele Basilicata,
  • Agostino Chiaravalloti,
  • Nicola Giannotti,
  • Amalia Lupi,
  • Filippo Crimì and
  • Emilio Quaia

Cancer risk estimation remains one of the main unresolved challenges in human spaceflight beyond low Earth orbit, where astronauts are exposed to galactic cosmic rays, solar particle events, and high-linear energy transfer (high-LET) secondary radiat...

(This article belongs to the Section Cancer Imaging)
  • Article
  • Open Access
773 Views
21 Pages

Can AI Detect What Is Not Injected? Evaluation of Lesion Detection in Virtual Contrast-Enhanced Breast MRI Using a Large-Scale AI Model Trained on GBCA-Enhanced Data

  • Shirin Heidarikahkesh,
  • Hannes Schreiter,
  • Aju George,
  • Tri-Thien Nguyen,
  • Dominika Skwierawska,
  • Luise Brock,
  • Dominique Hadler,
  • Michael Uder,
  • Frederik B. Laun and
  • Sebastian Bickelhaupt
  • + 7 authors

Background/Objectives: Artificial intelligence (AI) can support lesion detection in gadolinium-based contrast agent-enhanced (GBCA-enhanced) breast MRI. However, its effectiveness on virtual contrast-enhanced (vCE) images remains unclear. This feasib...

  • Article
  • Open Access
481 Views
22 Pages

Clinical Robustness of FDG-PET/CT Quantitative Metrics Post-Harmonization in a Multicenter, Cross-Scanner Setting

  • Ayako Hino,
  • Yoshinobu Ishiwata,
  • Akira Kakiuchi,
  • Tomohiro Numata,
  • Hiroyuki Kamide,
  • Hiroaki Kurihara,
  • Zenjiro Sekikawa and
  • Daisuke Utsunomiya

Background/Objectives: Differences among scanners and reconstruction methods may limit the comparability of quantitative metrics derived from fluorodeoxyglucose positron emission tomography (FDG PET)/computed tomography (CT). Although harmonization r...

(This article belongs to the Special Issue Progress in the Use of Advanced Imaging for Radiation Oncology)
  • Article
  • Open Access
631 Views
15 Pages

Radiographic Analysis of Lower Limb Alignment in Patients with Knee Osteoarthritis

  • Ozden Bedre Duygu,
  • Figen Govsa,
  • Anil Murat Ozturk and
  • Mehmet Alp Ozmen

Background and Objectives: Knee osteoarthritis (OA) is a prevalent musculoskeletal disorder. This study aims to assess the hip-knee-ankle anatomical alignment in patients with OA at different stages. Materials and Methods: Radiological images of 200...

(This article belongs to the Special Issue Orthopaedic Radiology: Establishing Radiologic Measurements as Diagnostic Tools and Criteria for Treatment)
  • Article
  • Open Access
749 Views
17 Pages

Impact of Different Energy Levels of Virtual Monoenergetic Reconstructions on Radiomic Features Stability in Organic Phantom Imaging Using Photon-Counting CT

  • Farroch Vahidi Noghani,
  • Lukas T. Rotkopf,
  • Stefan O. Schoenberg,
  • Matthias F. Froelich,
  • Isabelle Ayx and
  • Alexander Hertel

Objectives: This study investigates the repeatability and reproducibility of radiomic features extracted from different energy levels of virtual monoenergetic reconstruction (VMER) and polyenergetic reconstruction (PER) obtained with photon-counting...

(This article belongs to the Section Cancer Imaging)
  • Article
  • Open Access
690 Views
14 Pages

CT-Based Three-Dimensional Volumetric Analysis of Posterior and Lateral Malleolar Fragments in SER-Type Trimalleolar Ankle Fractures: Correlation and Reproducibility Study

  • Ruhat Ünlü,
  • Barış Yılmaz,
  • Hasan Emirhan Usta,
  • Hamit Çağlayan Kahraman,
  • Gülşah Yıldırım and
  • Celaleddin Bildik

Background: Posterior malleolar fractures are commonly assessed using two-dimensional measurements and morphology-based classification systems. However, ankle fracture morphology is inherently three-dimensional, and the reproducibility of CT-based vo...

  • Article
  • Open Access
487 Views
13 Pages

Purpose: To develop and technically validate a reproducible multicentre MRI radiomics workflow for pancreatic cyst risk stratification using paired T1- and T2-weighted imaging from public datasets. Methods: Public datasets were screened and Cyst-X wa...

(This article belongs to the Special Issue Cutting-Edge Applications: Artificial Intelligence and Deep Learning Revolutionizing CT and MRI)
  • Article
  • Open Access
593 Views
13 Pages

Objective: The objective of this study was to investigate the relationship between intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and dynamic contrast-enhanced MRI (DCE-MRI) parameters in soft tissue tumors (STTs). Methods: This r...

(This article belongs to the Section Cancer Imaging)
  • Article
  • Open Access
602 Views
15 Pages

Ambient Ozone Exposure and Pneumothorax Risk After CT-Guided Lung Biopsy

  • Nour Afilal,
  • Alois Komarek,
  • Michael Dieckmeyer,
  • Elif Can,
  • Martin Jonczyk,
  • Johannes T. Heverhagen and
  • Michael P. Brönnimann

Background/Objectives: To evaluate whether day-of-procedure ambient ozone exposure is associated with pneumothorax after CT-guided lung biopsy. Methods: This retrospective single-centre study included 160 CT-guided lung biopsies performed between Jan...

  • Article
  • Open Access
649 Views
13 Pages

Aim: This study aimed to evaluate the impact of cone beam computed tomography (CBCT) on preoperative surgical decision-making and risk assessment for mandibular third molar (MM3) extractions in cases identified as high-risk by orthopantomography (OPG...

(This article belongs to the Special Issue Medical Image Analysis in CT Imaging)
  • Article
  • Open Access
613 Views
32 Pages

Background/Objectives: Reliable uncertainty quantification (UQ) is a prerequisite for deploying automated systems in safety-critical medical imaging workflows, yet existing approaches either sacrifice computational efficiency or provide poorly calibr...

  • Article
  • Open Access
594 Views
15 Pages

Background/Objectives: Virtual Bronchoscopic Navigation is used to guide bronchoscopes toward peripheral pulmonary lesions, but broad clinical and research adoption remains limited by the cost of proprietary software and by segmentation failures in s...

(This article belongs to the Special Issue Medical Image Analysis in CT Imaging)
  • Article
  • Open Access
392 Views
15 Pages

Background: Patients with diabetes mellitus and nonobstructive coronary artery disease (NOCAD) may remain at increased cardiovascular risk despite the absence of flow-limiting stenosis. Quantitative coronary CT angiography (CCTA) enables comprehensiv...

(This article belongs to the Section Cardiovascular Imaging)
  • Article
  • Open Access
491 Views
20 Pages

Background: Multimodal breast ultrasound, including B-mode imaging, color Doppler flow imaging, and elastography, provides complementary information for lesion characterization. However, effectively integrating heterogeneous modalities remains challe...

(This article belongs to the Special Issue Imaging in Cancer Diagnosis)
  • Article
  • Open Access
726 Views
19 Pages

Improving the Identification of the Preclinical Stages of Spinocerebellar Ataxia Type 2

  • Camilo Mora-Batista,
  • Cruz Vargas-De-León,
  • Ramón Reyes-Carreto,
  • Frank J. Carrillo-Rodes and
  • José Alberto Álvarez-Cuesta

Background: Spinocerebellar ataxia type 2 (SCA2) is an inherited neurodegenerative disorder characterized by progressive cerebellar degeneration. One difficulty in treating this disease lies in identifying preclinical carriers: individuals who carry...

(This article belongs to the Section Neuroimaging)
  • Article
  • Open Access
520 Views
12 Pages

Purpose: To investigate the agreement on perfusion parameters derived from two different commercially available solutions for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with prostate cancer (PCa). Methods: A total of 5...

(This article belongs to the Special Issue Progress in the Use of Advanced Imaging for Radiation Oncology)
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Tomography - ISSN 2379-139X