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Journal of Cardiovascular Development and Disease, Volume 12, Issue 6

June 2025 - 38 articles

Cover Story: Vascular calcification serves as the most significant predictor of a cardiovascular event with no current therapeutic options for prevention or reversal. Vascular calcification is a complex disease that includes many different cell types and progresses at varying rates in different layers of the artery. This review explores the mechanisms, pathways, risk factors, and research models of vascular calcification and identifies potential therapeutic targets and discusses key considerations required for future development. View this paper
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Articles (38)

  • Review
  • Open Access
1,818 Views
21 Pages

Navigating the Complexities of Cancer Treatment-Induced Hypertension

  • Jose Arriola-Montenegro,
  • John Roth and
  • Maria L. Gonzalez Suarez

Cancer therapy-induced hypertension (HTN) is an increasingly recognized complication associated with a wide range of anticancer agents, including vascular endothelial growth factor (VEGF) inhibitors, proteasome inhibitors, tyrosine kinase inhibitors,...

  • Article
  • Open Access
1 Citations
581 Views
16 Pages

Predictors of Five-Year Outcomes in Patients with Acute Coronary Syndromes

  • Luca Di Vito,
  • Giancarla Scalone,
  • Federico Di Giusto,
  • Filippo Bruscoli,
  • Simona Silenzi,
  • Adelina Selimi,
  • Arianna Massari,
  • Domenico Delfino,
  • Federico Guerra and
  • Pierfrancesco Grossi

Background: Residual risk after acute coronary syndromes (ACSs) continues to affect prognosis. We investigated the impact of female sex, non-ST-segment–elevation myocardial infarction (NSTEMI), diabetes mellitus (DM), and chronic kidney disease...

  • Review
  • Open Access
1,597 Views
25 Pages

Anesthesia for Minimally Invasive Coronary Artery Bypass Surgery

  • Miranda Holmes,
  • Alexander N. J. White,
  • Luke J. Rogers and
  • Piroze M. Davierwala

Minimally invasive coronary artery bypass grafting (MI-CABG) has emerged as a transformative approach to coronary revascularization, offering reduced morbidity, faster recovery and improved cosmesis compared to conventional coronary artery bypass gra...

  • Review
  • Open Access
1,213 Views
14 Pages

Mitral Annular Calcification, a Not So Marginal and Relatively Benign Finding as Many of Us Think: A Review

  • András Vereckei,
  • Zsigmond Jenei,
  • Hajnalka Vágó,
  • Dorottya Balla,
  • Alexisz Panajotu,
  • Andrea Nagy and
  • Gábor Katona

Mitral annular calcification (MAC) is usually considered an incidental, benign, age-related finding without serious complications in patients evaluated for cardiovascular or pulmonary disease with imaging studies that may result in mitral regurgitati...

  • Article
  • Open Access
1 Citations
995 Views
14 Pages

Mental Health Treatment in Adults with Congenital Heart Disease in Germany: An Online, Cross-Sectional Study of Status, Needs, and Treatment Reasons

  • Anna-Lena Ehmann,
  • Emily Schütte,
  • Janina Semmler,
  • Felix Berger,
  • Ulrike M. M. Bauer,
  • Katharina Schmitt,
  • Constanze Pfitzer and
  • Paul C. Helm

Improved medical treatments have extended survival and life expectancy in adults with congenital heart defects (ACHD), placing greater emphasis on psychosocial health. Up to one-third of ACHD experience anxiety or depression, and half develop a menta...

  • Review
  • Open Access
3,182 Views
37 Pages

Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine

  • Jay Bharatsingh Bisen,
  • Hayden Sikora,
  • Anushree Aneja,
  • Sanjiv J. Shah and
  • Rukhsana G. Mirza

Rising morbidity and mortality from cardiovascular disease (CVD) have increased interest in precision and preventive management to reduce long-term sequelae. While retinal imaging has traditionally been recognized for identifying vascular changes in...

  • Review
  • Open Access
1 Citations
1,391 Views
15 Pages

Early Echocardiographic Markers in Heart Failure with Preserved Ejection Fraction

  • Annamaria Tavernese,
  • Vincenzo Rizza,
  • Valeria Cammalleri,
  • Rocco Mollace,
  • Cristina Carresi,
  • Giorgio Antonelli,
  • Nino Cocco,
  • Luca D’Antonio,
  • Martina Gelfusa and
  • Francesco Piccirillo
  • + 2 authors

Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases and remains diagnostically challenging due to its heterogeneous pathophysiology and often subtle myocardial dysfunction. Conventional echocardiog...

  • Case Report
  • Open Access
1,335 Views
11 Pages

Severe Myocardial Involvement and Persistent Supraventricular Arrhythmia in a Premature Infant Due to Enterovirus Infection: Case Report and Literature Review

  • Carolina Montobbio,
  • Alessio Conte,
  • Andrea Calandrino,
  • Alessia Pepe,
  • Francesco Vinci,
  • Alessandra Siboldi,
  • Roberto Formigari and
  • Luca Antonio Ramenghi

Enterovirus (EV) infections in neonates can be transmitted vertically or horizontally, with symptoms ranging from mild to severe, including myocarditis, meningoencephalitis, and hepatitis. Neonates with EV-induced myocarditis may present severe cardi...

  • Article
  • Open Access
640 Views
12 Pages

Prognostic Value of the Global Left Ventricular Contractility Index in Patients with Severe Mitral Regurgitation and Preserved Left Ventricular Ejection Fraction

  • Tony Li,
  • Vinay B. Panday,
  • Jessele Lai,
  • Nicholas Gao,
  • Beth Lim,
  • Aloysius Leow,
  • Sarah Tan,
  • Quek Swee Chye,
  • Ching Hui Sia and
  • William Kong
  • + 4 authors

Introduction: Assessment of left ventricular (LV) systolic function is important in valvular heart disease. The global LV contractility index, dσ*/dtmax, is load-independent and has been reported to be associated with clinical outcomes in heart...

  • Reply
  • Open Access
337 Views
3 Pages

Reply to Neunhaeuserer et al. Comment on “Bianco et al. Differences in Arrhythmia Detection Between Harvard Step Test and Maximal Exercise Testing in a Paediatric Sports Population. J. Cardiovasc. Dev. Dis. 2025, 12, 22”

  • Massimiliano Bianco,
  • Fabrizio Sollazzo,
  • Riccardo Pella,
  • Saverio Vicentini,
  • Samuele Ciaffoni,
  • Gloria Modica,
  • Riccardo Monti,
  • Michela Cammarano,
  • Paolo Zeppilli and
  • Vincenzo Palmieri

We have read the commentary on our article entitled ‘Differences in Arrhythmia Detection Between Harvard Step Test and Maximal Exercise Testing in a Paediatric Sports Population’ [...]

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425Creative Common CC BY license