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Journal of Cardiovascular Development and Disease, Volume 12, Issue 11

2025 November - 38 articles

Cover Story: Amyloid cardiomyopathy (ACM) is a progressive and often fatal heart disease caused by misfolded transthyretin (TTR) or immunoglobulin light chains that infiltrate and stiffen the myocardium. Human-induced pluripotent stem cells (iPSCs) now turn this challenge into an opportunity by providing a patient-specific window into ACM pathogenesis. In this review, Liu & Riaz illustrate how hepatocytes derived from patient-specific TTR-mutant iPSCs recapitulate amyloid secretion, whereas iPSC-derived cardiomyocytes model amyloid-induced proteotoxic stress in both two- and three-dimensional engineered tissues. The integration of CRISPR-Cas9 genome editing and dynamic 3D conditioning further enhances mechanistic fidelity and enables drug screening. Together, these human-relevant platforms link genotype to phenotype and accelerate precision drug discovery for ACM. View this paper
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Articles (38)

  • Article
  • Open Access
466 Views
15 Pages

The Conducting Tissues of the Mouse Heart

  • Yolanda Macías,
  • Damián Sánchez-Quintana,
  • Eduardo Back Sternick and
  • Robert H. Anderson

Background: Since the study of Lev and Thaemert in 1973, little has been published concerning the overall arrangement of the murine conduction tissues, in particular with relation to gross anatomical landmarks. We recently emphasised the potential va...

  • Review
  • Open Access
494 Views
10 Pages

Left Ventricular Apical Cannulation in Acute Type A Aortic Dissection

  • Benedetto Ferraresi,
  • Antonio Nenna,
  • Mohamad Jawabra,
  • Diletta Corrado,
  • Filippo Barberi,
  • Carmelo Dominici,
  • Giovanni Casali,
  • Massimo Chello and
  • Mario Lusini

Background and objectives: In cases of acute type A aortic dissection, including iatrogenic cases following transcatheter procedures, the choice of arterial cannulation site has a critical influence on early haemodynamics, organ protection and the ri...

  • Review
  • Open Access
817 Views
13 Pages

Late Complications After Aortic Coarctation Repair

  • Annarita Santoro,
  • Fiorenza De Lisio,
  • Alexandra Fedorovna Bezborodova,
  • Roberto Chiesa and
  • Germano Melissano

Aortic coarctation (CoA) is a congenital vascular anomaly characterized by luminal narrowing of the aorta, representing approximately 5–8% of all congenital heart defects, and is frequently associated with a bicuspid aortic valve and additional...

  • Article
  • Open Access
890 Views
26 Pages

Cardiomyocyte Nuclear Pleomorphism in a Mouse Model of Inherited Hypertrophic Cardiomyopathy

  • Jamie R. Johnston,
  • Isabella Leite Coscarella,
  • Carson L. Rose,
  • Yun Shi,
  • Hosna Rastegarpouyani,
  • Karissa M. Dieseldorff Jones,
  • Jennifer M. Le Patourel,
  • Feyikemi Ogunfuwa,
  • Adriano S. Martins and
  • Prescott Bryant Chase
  • + 9 authors

Mutations in genes encoding sarcomeric proteins are a common cause of cardiomyopathy and sudden cardiac death in humans. We evaluated the hypothesis that myofilament dysfunction is coupled to morphological and functional alterations of cardiomyocyte...

  • Article
  • Open Access
540 Views
13 Pages

CaReMe-CKD-HF–Epidemiology of Heart Failure in Chronic Kidney Disease: A Retrospective Analysis of Routine Administrative Data from a German Hospital Network

  • Lars Stellmacher,
  • Sebastian König,
  • Johannes Leiner,
  • Vincent Pellissier,
  • Sven Hohenstein,
  • Jakob Birnbaum,
  • Stefan Kwast,
  • Carolin Schanner,
  • Ralf Kuhlen and
  • Andreas Bollmann

Background: Heart failure (HF) is a frequent and clinically relevant comorbidity in patients with chronic kidney disease (CKD). Both conditions are closely linked through hemodynamic, neurohormonal, and inflammatory mechanisms, resulting in excess mo...

  • Article
  • Open Access
577 Views
18 Pages

Sex-Specific Expression Patterns of MYH6 and MYH7 Gene Transcripts in Large Cohorts of Non-Failing and Failing Human Left Ventricular Tissues

  • Zdenko Červenák,
  • Ján Somorčík,
  • Yashar Jalali,
  • Žaneta Zajacová,
  • Marian Baldovič,
  • Andrea Gažová and
  • Ján Kyselovič

The transcriptional regulation of MYH6 and MYH7 genes has been extensively investigated in healthy versus failing hearts; however, their expression dynamics in healthy human hearts across age and sex, particularly in the context of cardiovascular ris...

  • Retraction
  • Open Access
279 Views
1 Page

The Journal of Cardiovascular Development and Disease retracts the article “A Systematic Review of Personalized Health Applications through Human–Computer Interactions (HCI) on Cardiovascular Health Optimization” [...]

  • Review
  • Open Access
1,516 Views
21 Pages

Lipid Profile and Management of Dyslipidemias in Pregnancy

  • Constantine E. Kosmas,
  • Loukianos S. Rallidis,
  • Ioannis Hoursalas,
  • Eleni-Angeliki Zoumi and
  • Christina E. Kostara

Dyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). Abnormal maternal lipid profiles in pregnancy are associated with pregnancy complications including preeclampsia, gestational diabetes, and pre-term deliver...

  • Article
  • Open Access
548 Views
19 Pages

In single ventricle (SV) patients, veno-venous (VVCs) and major aortopulmonary collaterals (APCs) are common. We aim to determine the differences between patients with and without interventional closure of VVCs or APCs in this single-center, retrospe...

  • Article
  • Open Access
606 Views
11 Pages

Background: The atherogenic index of plasma (AIP) is a marker of lipids and atherosclerosis. However, the association between the AIP and the risk of unstable carotid plaque remains unclear. Methods: A total of 10,732 patients were enrolled. Carotid...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425