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Journal of Cardiovascular Development and Disease, Volume 12, Issue 10

October 2025 - 41 articles

Cover Story: The epicardium plays a pivotal role in heart development and regeneration through its lineage contributions and paracrine signaling. Recent advances in lineage tracing, single-cell profiling, and human pluripotent stem cell-derived cardiac organoids have revealed new insights into the cellular diversity and dynamic interactions between epicardial cells, cardiomyocytes, endothelial cells, and immune cells. These models uncover both conserved and divergent mechanisms underlying epicardial function and cardiac repair. This review integrates findings from developmental, regenerative, and organoid studies to present an updated perspective on epicardial biology and its therapeutic potential. View this paper
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Articles (41)

  • Article
  • Open Access
311 Views
11 Pages

Prescription Trends and the Role of Cardiologists in the Diagnosis and Treatment of Erectile Dysfunction

  • Filip Tkaczyk,
  • Michal Chudzik,
  • Aleksandra M. Piotrowska,
  • Tim Stolpe,
  • Julia Zurawska and
  • Zbigniew Siudak

Introduction: Erectile dysfunction (ED) is strongly associated with metabolic and cardiovascular diseases and may serve as a marker of vascular pathology. Phosphodiesterase type 5 (PDE-5) inhibitors are the mainstay of treatment. Considering this lin...

  • Article
  • Open Access
281 Views
13 Pages

Risk Factors for Reintervention in Children with Subvalvular Aortic Stenosis: A 20-Year Single-Center Study

  • Jelena Hubrechts,
  • Alessandra Zanfardino,
  • Catherine Barrea,
  • Thierry Detaille and
  • Alain Poncelet

Subvalvular aortic stenosis (SAS) is a frequent cause of left ventricular outflow tract (LVOT) obstruction in children. Surgical resection is the standard treatment, yet recurrence requiring reintervention remains a significant concern. We aim to ide...

  • Article
  • Open Access
364 Views
11 Pages

Background: Pulse field ablation (PFA) is a novel ablation technology with efficacy and safety, potentially making it a preferred ablation technology for persistent atrial fibrillation (AF). There is no optimal procedural workflow established to opti...

  • Reply
  • Open Access
206 Views
2 Pages

Reply to Al Ebrahim, K.E. Comment on “Leivaditis et al. Between Air and Artery: A History of Cardiopulmonary Bypass and the Rise of Modern Cardiac Surgery. J. Cardiovasc. Dev. Dis. 2025, 12, 365”

  • Vasileios Leivaditis,
  • Andreas Maniatopoulos,
  • Francesk Mulita,
  • Paraskevi Katsakiori,
  • Nikolaos G. Baikoussis,
  • Sofoklis Mitsos,
  • Elias Liolis,
  • Vasiliki Garantzioti,
  • Konstantinos Tasios and
  • Panagiotis Leventis
  • + 6 authors

We are grateful to Dr. Al Ebrahim for his thoughtful and constructive commentary on our historical review of cardiopulmonary bypass (CPB) [...]

  • Review
  • Open Access
322 Views
27 Pages

Coronary Bifurcation PCI—Part I: Fundamentals

  • Sara Pollanen,
  • Rongras Damrongwatanasuk,
  • Ju Young Bae,
  • Jason Wen,
  • Michael G. Nanna,
  • Abdulla Al-Damluji,
  • Mamas A. Mamas,
  • Elias B. Hanna and
  • Jiun-Ruey Hu

Percutaneous coronary intervention (PCI) of bifurcation lesions remain one of the most technically challenging areas in interventional cardiology. Careful planning and execution are needed to preserve main vessel and side branch patency, with evolvin...

  • Case Report
  • Open Access
358 Views
14 Pages

Aortic Regurgitation in a Patient with Rheumatoid Arthritis/Systemic Lupus Erythematosus Overlap Syndrome (Rhupus): Case Report and Review of Literature

  • Mislav Radić,
  • Hana Đogaš,
  • Tina Bečić,
  • Petra Šimac,
  • Ivana Jukić,
  • Josipa Radić and
  • Damir Fabijanić

Background/Objectives: Cardiovascular diseases (CVDs), including valvular heart disease (VHD), remain the leading cause of morbidity and mortality in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Case Presentation: W...

  • Review
  • Open Access
339 Views
11 Pages

Surgical Explantation of Transcatheter Aortic Valve Requires Patient-Tailored Management, but Challenges Remain

  • Vasiliki Androutsopoulou,
  • Andrew Xanthopoulos,
  • Kalliopi Keramida,
  • Arian Arjomandi Rad,
  • Georgia Nazou,
  • Prokopis-Andreas Zotos,
  • John Skoularigis,
  • Thanos Athanasiou and
  • Dimitrios C. Iliopoulos

Transcatheter aortic valve replacement has become a widely accepted alternative to surgical aortic valve replacement even in younger, lower-risk patients with longer life expectancy. The increasing use of transcatheter aortic valve replacement is lea...

  • Review
  • Open Access
858 Views
17 Pages

Addressing Complications in Cardiac Implantable Electronic Devices: A Guideline to Prevention of CIED Infection

  • Benito Baldauf,
  • Roberto Cemin,
  • Mauro Biffi,
  • Antonio Rapacciuolo,
  • Giulio Zucchelli,
  • Maria Grazia Bongiorni,
  • Ernesto Casorelli,
  • Gianfranco Mitacchione,
  • Felix Hohendanner and
  • Emanuele Durante-Mangoni
  • + 14 authors

Background: Cardiac implantable electronic devices (CIEDs) are vital for managing arrhythmias but carry a notable risk of infection, which increases patient morbidity, mortality, and healthcare burden. This review examines current evidence on risk fa...

  • Article
  • Open Access
512 Views
13 Pages

Pilot Study Assessing the Hemodynamic Impact and Post-Exercise Hypotension Induced by High- Versus Low-Intensity Isometric Handgrip in Patients with Ischemic Heart Disease

  • Giuseppe Caminiti,
  • Matteo Vitarelli,
  • Maurizio Volterrani,
  • Giuseppe Marazzi,
  • Vincenzo Manzi,
  • Valentino D’Antoni,
  • Simona Fecondo,
  • Sara Vadalà,
  • Barbara Sposato and
  • Domenico Mario Giamundo
  • + 4 authors

Background: Isometric handgrip (IHG) exercise reduces blood pressure (BP) in both normotensive and hypertensive individuals. However, there are few studies specifically addressing its effects in hypertensive patients with ischemic heart disease (IHD)...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425Creative Common CC BY license