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Bioengineering, Volume 8, Issue 1

January 2021 - 14 articles

Cover Story: The use of electrospun fibers for neural repair is advantageous since fibers can be fabricated to mimic the native nervous system extracellular matrix and provide contact guidance for infiltrating glia and regenerating axons. The various characteristics of electrospun fibers, such as fiber alignment, diameter, surface nanotopography, surface chemistry, and therapeutic delivery, can be modified to achieve a desired glial cell response to injury. Here, we show that changing the diameter of aligned electrospun fibers can enhance the uniaxial elongation of glia, which is shown to improve glial-cell-mediated neurite extension. View this paper

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Articles (14)

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Review

45 Citations

9,176 Views

35 Pages

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

Devan L. Puhl,
Jessica L. Funnell,
Derek W. Nelson,
Manoj K. Gottipati and
Ryan J. Gilbert

Bioengineering2021, 8(1), 4;https://doi.org/10.3390/bioengineering8010004

29 December 2020

Electrospinning is a fabrication technique used to produce nano- or micro- diameter fibers to generate biocompatible, biodegradable scaffolds for tissue engineering applications. Electrospun fiber scaffolds are advantageous for neural regeneration be...

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Review

79 Citations

13,538 Views

23 Pages

Collagen Structure-Function Mapping Informs Applications for Regenerative Medicine

James D. San Antonio,
Olena Jacenko,
Andrzej Fertala and
Joseph P.R.O. Orgel

Bioengineering2021, 8(1), 3;https://doi.org/10.3390/bioengineering8010003

29 December 2020

Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues. Collagen plays roles in hemostasis, wound healing, angiogenesis, and biomineralization, a...

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Review

24 Citations

18,088 Views

14 Pages

Spinal Deformities and Advancement in Corrective Orthoses

Athar Ali,
Vigilio Fontanari,
Marco Fontana and
Werner Schmölz

Bioengineering2021, 8(1), 2;https://doi.org/10.3390/bioengineering8010002

25 December 2020

Spinal deformity is an abnormality in the spinal curves and can seriously affect the activities of daily life. The conventional way to treat spinal deformities, such as scoliosis, kyphosis, and spondylolisthesis, is to use spinal orthoses (braces). B...

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Article

18 Citations

4,348 Views

16 Pages

Breast Cancer Cell Cultures on Electrospun Poly(ε-Caprolactone) as a Potential Tool for Preclinical Studies on Anticancer Treatments

Bianca Bazzolo,
Elisabetta Sieni,
Annj Zamuner,
Martina Roso,
Teresa Russo,
Antonio Gloria,
Monica Dettin and
Maria Teresa Conconi

Bioengineering2021, 8(1), 1;https://doi.org/10.3390/bioengineering8010001

22 December 2020

During anticancer drug development, most compounds selected by in vitro screening are ineffective in in vivo studies and clinical trials due to the unreliability of two-dimensional (2D) in vitro cultures that are unable to mimic the cancer microenvir...

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