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Bioengineering, Volume 8, Issue 2

2021 February - 16 articles

Cover Story: Collagen fiber formation is essential to human health. Over the last decade, there has been growing evidence that collagen fiber organization is not only a structural scaffold for normal tissue function, but, in some instances, it correlates with cancer onset and progression. In this review, we focus on the published evidence showing that fibrillar collagen organization and structure is an important factor and potential candidate biomarker in disease etiology and progression in a wide variety of cancers. We review the literature pertaining to collagen morphology in diagnosis, patient prognosis, and treatment response in many cancer types. View this paper
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Articles (16)

  • Review
  • Open Access
46 Citations
9,420 Views
31 Pages

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

  • Alberto Giubilini,
  • Federica Bondioli,
  • Massimo Messori,
  • Gustav Nyström and
  • Gilberto Siqueira

In recent years, biopolymers have been attracting the attention of researchers and specialists from different fields, including biotechnology, material science, engineering, and medicine. The reason is the possibility of combining sustainability with...

  • Review
  • Open Access
168 Citations
26,347 Views
19 Pages

High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases

  • Hasan Aldewachi,
  • Radhwan N. Al-Zidan,
  • Matthew T. Conner and
  • Mootaz M. Salman

Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in progressive degeneration and/or death of nerve cells in the central nervous system (CNS). Identification of viable therapeutic targets and new treatments for C...

  • Review
  • Open Access
200 Citations
16,615 Views
19 Pages

Natural Biomaterials and Their Use as Bioinks for Printing Tissues

  • Claire Benwood,
  • Josie Chrenek,
  • Rebecca L. Kirsch,
  • Nadia Z. Masri,
  • Hannah Richards,
  • Kyra Teetzen and
  • Stephanie M. Willerth

The most prevalent form of bioprinting—extrusion bioprinting—can generate structures from a diverse range of materials and viscosities. It can create personalized tissues that aid in drug testing and cancer research when used in combination with natu...

  • Article
  • Open Access
15 Citations
4,438 Views
11 Pages

Electrochemically based technologies are rapidly moving from the laboratory to bedside applications and wearable devices, like in the field of cardiovascular disease. Major efforts have focused on the biosensor component in contrast with those employ...

  • Article
  • Open Access
32 Citations
9,399 Views
9 Pages

An Open-Source COVID-19 CT Dataset with Automatic Lung Tissue Classification for Radiomics

  • Paolo Zaffino,
  • Aldo Marzullo,
  • Sara Moccia,
  • Francesco Calimeri,
  • Elena De Momi,
  • Bernardo Bertucci,
  • Pier Paolo Arcuri and
  • Maria Francesca Spadea

The coronavirus disease 19 (COVID-19) pandemic is having a dramatic impact on society and healthcare systems. In this complex scenario, lung computerized tomography (CT) may play an important prognostic role. However, datasets released so far present...

  • Review
  • Open Access
8 Citations
4,738 Views
10 Pages

This paper deals with a brief review of the recent developments in computational modelling applied to innovative treatments of spine diseases. Additionally, it provides a perspective on the research directions expected for the forthcoming years. The...

  • Article
  • Open Access
31 Citations
5,597 Views
18 Pages

Conductive polymers (CPs) have recently been applied in the development of scaffolds for tissue engineering applications in attempt to induce additional cues able to enhance tissue growth. Polyaniline (PANI) is one of the most widely studied CPs, but...

  • Article
  • Open Access
37 Citations
15,301 Views
20 Pages

CRISPR/Cas9-Based Lateral Flow and Fluorescence Diagnostics

  • Mark J. Osborn,
  • Akshay Bhardwaj,
  • Samuel P. Bingea,
  • Friederike Knipping,
  • Colby J. Feser,
  • Christopher J. Lees,
  • Daniel P. Collins,
  • Clifford J. Steer,
  • Bruce R. Blazar and
  • Jakub Tolar

Clustered regularly interspaced short palindromic repeat (CRISPR/Cas) proteins can be designed to bind specified DNA and RNA sequences and hold great promise for the accurate detection of nucleic acids for diagnostics. We integrated commercially avai...

  • Article
  • Open Access
14 Citations
4,159 Views
17 Pages

Decision Trees for Predicting Mortality in Transcatheter Aortic Valve Implantation

  • Marco Mamprin,
  • Jo M. Zelis,
  • Pim A. L. Tonino,
  • Sveta Zinger and
  • Peter H. N. de With

Current prognostic risk scores in cardiac surgery do not benefit yet from machine learning (ML). This research aims to create a machine learning model to predict one-year mortality of a patient after transcatheter aortic valve implantation (TAVI). We...

  • Article
  • Open Access
13 Citations
4,843 Views
14 Pages

A Deep Classifier for Upper-Limbs Motor Anticipation Tasks in an Online BCI Setting

  • Andrea Valenti,
  • Michele Barsotti,
  • Davide Bacciu and
  • Luca Ascari

Decoding motor intentions from non-invasive brain activity monitoring is one of the most challenging aspects in the Brain Computer Interface (BCI) field. This is especially true in online settings, where classification must be performed in real-time,...

  • Article
  • Open Access
22 Citations
6,208 Views
15 Pages

Multi-Compartment Lymph-Node-on-a-Chip Enables Measurement of Immune Cell Motility in Response to Drugs

  • Nicholas Hallfors,
  • Aya Shanti,
  • Jiranuwat Sapudom,
  • Jeremy Teo,
  • Georg Petroianu,
  • SungMun Lee,
  • Lourdes Planelles and
  • Cesare Stefanini

Organs On-a-Chip represent novel platforms for modelling human physiology and disease. The lymph node (LN) is a relevant immune organ in which B and T lymphocytes are spatially organized in a complex architecture, and it is the place where the immune...

  • Article
  • Open Access
6 Citations
4,217 Views
10 Pages

Preoperative Planning of Spiral Intestinal Lengthening and Tailoring: A Geometrical Approach

  • Riccardo Coletta,
  • Elisa Mussi,
  • Francesca Uccheddu,
  • Yary Volpe and
  • Antonino Morabito

Short bowel syndrome is a pathological condition resulting from extensive resection of the intestine, generally performed due to congenital abnormalities, Crohn’s disease, mesenteric ischemia, or neoplasms. The main consequence of this syndrome...

  • Article
  • Open Access
10 Citations
5,257 Views
12 Pages

Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly worldwide. So far, the etiology and the progression of AMD are not well known. Animal models have been developed to study the mechanisms involved in AMD; howeve...

  • Review
  • Open Access
64 Citations
10,214 Views
19 Pages

Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer

  • Jonathan N. Ouellette,
  • Cole R. Drifka,
  • Kelli B. Pointer,
  • Yuming Liu,
  • Tyler J Lieberthal,
  • W John Kao,
  • John S. Kuo,
  • Agnes G. Loeffler and
  • Kevin W. Eliceiri

Recent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression. This led to great interest from both basic researchers and c...

  • Article
  • Open Access
9 Citations
5,778 Views
14 Pages

The administration of gene-editing tools has been proposed as a promising therapeutic approach for correcting mutations that cause diseases. Gene-editing tools, composed of relatively large plasmid DNA constructs that often need to be co-delivered wi...

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Bioengineering - ISSN 2306-5354