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Bioengineering, Volume 8, Issue 2

February 2021 - 16 articles

Cover Story: Collagen fiber formation is essential to human health. Over the last decade, there has been growing evidence that collagen fiber organization is not only a structural scaffold for normal tissue function, but, in some instances, it correlates with cancer onset and progression. In this review, we focus on the published evidence showing that fibrillar collagen organization and structure is an important factor and potential candidate biomarker in disease etiology and progression in a wide variety of cancers. We review the literature pertaining to collagen morphology in diagnosis, patient prognosis, and treatment response in many cancer types. View this paper
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Articles (16)

  • Review
  • Open Access
39 Citations
8,838 Views
31 Pages

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

  • Alberto Giubilini,
  • Federica Bondioli,
  • Massimo Messori,
  • Gustav Nyström and
  • Gilberto Siqueira

In recent years, biopolymers have been attracting the attention of researchers and specialists from different fields, including biotechnology, material science, engineering, and medicine. The reason is the possibility of combining sustainability with...

  • Review
  • Open Access
149 Citations
25,045 Views
19 Pages

High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases

  • Hasan Aldewachi,
  • Radhwan N. Al-Zidan,
  • Matthew T. Conner and
  • Mootaz M. Salman

Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in progressive degeneration and/or death of nerve cells in the central nervous system (CNS). Identification of viable therapeutic targets and new treatments for C...

  • Review
  • Open Access
182 Citations
15,794 Views
19 Pages

Natural Biomaterials and Their Use as Bioinks for Printing Tissues

  • Claire Benwood,
  • Josie Chrenek,
  • Rebecca L. Kirsch,
  • Nadia Z. Masri,
  • Hannah Richards,
  • Kyra Teetzen and
  • Stephanie M. Willerth

The most prevalent form of bioprinting—extrusion bioprinting—can generate structures from a diverse range of materials and viscosities. It can create personalized tissues that aid in drug testing and cancer research when used in combination with natu...

  • Article
  • Open Access
15 Citations
4,266 Views
11 Pages

Electrochemically based technologies are rapidly moving from the laboratory to bedside applications and wearable devices, like in the field of cardiovascular disease. Major efforts have focused on the biosensor component in contrast with those employ...

  • Article
  • Open Access
29 Citations
8,443 Views
9 Pages

An Open-Source COVID-19 CT Dataset with Automatic Lung Tissue Classification for Radiomics

  • Paolo Zaffino,
  • Aldo Marzullo,
  • Sara Moccia,
  • Francesco Calimeri,
  • Elena De Momi,
  • Bernardo Bertucci,
  • Pier Paolo Arcuri and
  • Maria Francesca Spadea

The coronavirus disease 19 (COVID-19) pandemic is having a dramatic impact on society and healthcare systems. In this complex scenario, lung computerized tomography (CT) may play an important prognostic role. However, datasets released so far present...

  • Review
  • Open Access
8 Citations
4,517 Views
10 Pages

This paper deals with a brief review of the recent developments in computational modelling applied to innovative treatments of spine diseases. Additionally, it provides a perspective on the research directions expected for the forthcoming years. The...

  • Article
  • Open Access
27 Citations
5,155 Views
18 Pages

Conductive polymers (CPs) have recently been applied in the development of scaffolds for tissue engineering applications in attempt to induce additional cues able to enhance tissue growth. Polyaniline (PANI) is one of the most widely studied CPs, but...

  • Article
  • Open Access
34 Citations
14,553 Views
20 Pages

CRISPR/Cas9-Based Lateral Flow and Fluorescence Diagnostics

  • Mark J. Osborn,
  • Akshay Bhardwaj,
  • Samuel P. Bingea,
  • Friederike Knipping,
  • Colby J. Feser,
  • Christopher J. Lees,
  • Daniel P. Collins,
  • Clifford J. Steer,
  • Bruce R. Blazar and
  • Jakub Tolar

Clustered regularly interspaced short palindromic repeat (CRISPR/Cas) proteins can be designed to bind specified DNA and RNA sequences and hold great promise for the accurate detection of nucleic acids for diagnostics. We integrated commercially avai...

  • Article
  • Open Access
12 Citations
3,970 Views
17 Pages

Decision Trees for Predicting Mortality in Transcatheter Aortic Valve Implantation

  • Marco Mamprin,
  • Jo M. Zelis,
  • Pim A. L. Tonino,
  • Sveta Zinger and
  • Peter H. N. de With

Current prognostic risk scores in cardiac surgery do not benefit yet from machine learning (ML). This research aims to create a machine learning model to predict one-year mortality of a patient after transcatheter aortic valve implantation (TAVI). We...

  • Article
  • Open Access
13 Citations
4,676 Views
14 Pages

A Deep Classifier for Upper-Limbs Motor Anticipation Tasks in an Online BCI Setting

  • Andrea Valenti,
  • Michele Barsotti,
  • Davide Bacciu and
  • Luca Ascari

Decoding motor intentions from non-invasive brain activity monitoring is one of the most challenging aspects in the Brain Computer Interface (BCI) field. This is especially true in online settings, where classification must be performed in real-time,...

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Bioengineering - ISSN 2306-5354