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Bioengineering, Volume 7, Issue 1

March 2020 - 29 articles

Cover Story: Mechanical environments surrounding cancer cells, which include stiffness of the extracellular matrix, are altered during tumor progression and influence cell behaviors. In this study, we show that stiff matrices, through activation of the mechanotransducer YAP, increase the expression of MMP24, which encodes the membrane-type matrix metaroprotease-24. In addition, based on the human protein atlas database, high MMP24 expression is correlated with the prolonged overall survival rate of patients for several cancers, including breast cancer. View this paper.
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Articles (29)

  • Article
  • Open Access
20 Citations
7,003 Views
14 Pages

Fluorescent probes offer great potential to identify and treat surgical tumors by clinicians. To this end, several molecular probes were examined as in vitro and in vivo bioimaging probes. However, due to their ultra-low extinction coefficients as we...

  • Article
  • Open Access
12 Citations
6,927 Views
12 Pages

MMP24 as a Target of YAP Is a Potential Prognostic Factor in Cancer Patients

  • Wataru Sugimoto,
  • Katsuhiko Itoh,
  • Hiroaki Hirata,
  • Yoshinori Abe,
  • Takeru Torii,
  • Yasumasa Mitsui,
  • Yemima Budirahardja,
  • Nobuyuki Tanaka and
  • Keiko Kawauchi

The extracellular matrix (ECM) surrounding cancer cells becomes stiffer during tumor progression, which influences cancer cell behaviors such as invasion and proliferation through modulation of gene expression as well as remodeling of the actin cytos...

  • Review
  • Open Access
63 Citations
10,598 Views
18 Pages

Recapitulating the Vasculature Using Organ-On-Chip Technology

  • Andreas M.A.O. Pollet and
  • Jaap M.J. den Toonder

The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advant...

  • Article
  • Open Access
47 Citations
10,365 Views
17 Pages

Atrial fibrillation, often called AF is considered to be the most common type of cardiac arrhythmia, which is a major healthcare challenge. Early detection of AF and the appropriate treatment is crucial if the symptoms seem to be consistent and persi...

  • Article
  • Open Access
22 Citations
6,342 Views
10 Pages

Ethanol is a material that has a high demand from different industries such as fuel, beverages, and other industrial applications. Commonly, ethanol has been produced from yeast fermentation using sugar crops as a feedstock. However, food waste (FW)...

  • Article
  • Open Access
13 Citations
6,525 Views
11 Pages

Changes in Epithelial and Stromal Corneal Stiffness Occur with Age and Obesity

  • Peiluo Xu,
  • Anne Londregan,
  • Celeste Rich and
  • Vickery Trinkaus-Randall

The cornea is avascular, which makes it an excellent model to study matrix protein expression and tissue stiffness. The corneal epithelium adheres to the basement zone and the underlying stroma is composed of keratocytes and an extensive matrix of co...

  • Article
  • Open Access
16 Citations
7,327 Views
19 Pages

There is variability in the reported effects of compounds on osteoblasts arising from differences in experimental design and choice of cell type/origin. This makes it difficult to discern a compound’s action outside its original study and compa...

  • Article
  • Open Access
10 Citations
5,536 Views
13 Pages

Co-Networks Poly(hydroxyalkanoates)-Terpenes to Enhance Antibacterial Properties

  • Tina Modjinou,
  • Davy Louis Versace,
  • Samir Abbad Andaloussi,
  • Valérie Langlois and
  • Estelle Renard

Biocompatible and biodegradable bacterial polyesters, poly(hydroxyalkanoates) (PHAs), were combined with linalool, a well-known monoterpene, extracted from spice plants to design novel antibacterial materials. Their chemical association by a photo-in...

  • Article
  • Open Access
35 Citations
7,921 Views
17 Pages

Strontium- and Zinc-Containing Bioactive Glass and Alginates Scaffolds

  • Asfia Haider,
  • Ahmad Waseem,
  • Natalia Karpukhina and
  • Sahar Mohsin

With an increasingly elderly population, there is a proportionate increase in bone injuries requiring hospitalization. Clinicians are increasingly adopting tissue-engineering methods for treatment due to limitations in the use of autogenous and autol...

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Bioengineering - ISSN 2306-5354