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Toxics, Volume 6, Issue 1

2018 March - 18 articles

Cover Story: Health threat from cadmium contamination of our dietary staples and the air we breathe. Cadmium is a highly persistent environmental toxicant that also has higher rates of soil-to-plant transfer than lead and mercury. Humans are exposed to cadmium in dietary staples (rice, potato and wheat), cigarette smoke and polluted air. There are no therapeutically effective chelating agents to reduce the body content of cadmium. Public measures are required to minimize cadmium contamination of the food-chain to reduce health risk and to prevent the development of cadmium-associated diseases such as chronic kidney disease, bone fragility, and macular degeneration, a leading cause of blindness in adults. View the paper
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Articles (18)

  • Article
  • Open Access
2 Citations
5,368 Views
12 Pages

19 March 2018

The aim of this study is the application of a software tool to the design of stripping columns to calculate the removal of trihalomethanes (THMs) from drinking water. The tool also allows calculating the rough capital cost of the column and the decre...

  • Article
  • Open Access
14 Citations
5,948 Views
7 Pages

16 March 2018

Background: Few studies have investigated the association between radon and thyroid cancer despite the sensitivity of the thyroid gland to radiation. Our goal is to investigate the association between county-level radon and incidence of female thyroi...

  • Feature Paper
  • Article
  • Open Access
80 Citations
8,002 Views
14 Pages

Cadmium Nephrotoxicity Is Associated with Altered MicroRNA Expression in the Rat Renal Cortex

  • Michael J. Fay,
  • Lauren A. C. Alt,
  • Dominika Ryba,
  • Ribhi Salamah,
  • Ryan Peach,
  • Alexander Papaeliou,
  • Sabina Zawadzka,
  • Andrew Weiss,
  • Nil Patel and
  • Walter C. Prozialeck
  • + 4 authors

15 March 2018

Cadmium (Cd) is a nephrotoxic environmental pollutant that causes a generalized dysfunction of the proximal tubule characterized by polyuria and proteinuria. Even though the effects of Cd on the kidney have been well-characterized, the molecular mech...

  • Feature Paper
  • Review
  • Open Access
307 Citations
23,246 Views
23 Pages

10 March 2018

Cadmium (Cd) is a food-chain contaminant that has high rates of soil-to-plant transference. This phenomenon makes dietary Cd intake unavoidable. Although long-term Cd intake impacts many organ systems, the kidney has long been considered to be a crit...

  • Article
  • Open Access
4 Citations
4,746 Views
14 Pages

9 February 2018

The aim of this work is to prepare a proposal for the post-authorization monitoring (PAM) of veterinary medicinal products (VMP), in particular parasiticides. Such a monitoring might especially be useful for parasiticides identified as Persistence Bi...

  • Article
  • Open Access
23 Citations
6,235 Views
15 Pages

Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism

  • Nahid Ahmadi,
  • Ali Mandegary,
  • Akram Jamshidzadeh,
  • Mohaddeseh Mohammadi-Sardoo,
  • Mohammadreza Mohammadi-Sardo,
  • Elham Salari and
  • Leyla Pourgholi

7 February 2018

The widespread use of pesticides in agriculture represents a threat to the human populations exposed to them. In this cross-sectional study, the hematological and biochemical parameters, plasma cholinesterase (PChE) activity, oxidative stress, genoto...

  • Article
  • Open Access
21 Citations
4,434 Views
17 Pages

5 February 2018

Pharmacotherapy as the mainstay in the management of breast cancer has demonstrated various drawbacks, including non-targeted bio distribution and narrow therapeutic and safety windows. Thus, enhancements in pharmacodynamic and pharmacokinetic profil...

  • Article
  • Open Access
15 Citations
6,520 Views
11 Pages

Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment

  • Samantha A. Radford,
  • Parinya Panuwet,
  • Ronald E. Hunter Jr.,
  • Dana Boyd Barr and
  • P. Barry Ryan

2 February 2018

Since urinary insecticide metabolites are commonly used as biomarkers of exposure, it is important that we quantify whether insecticides degrade in food and beverages in order to better perform risk assessment. This study was designed to quantify deg...

  • Article
  • Open Access
30 Citations
5,776 Views
12 Pages

10 January 2018

The widespread occurrence of benzophenone-type ultraviolet (UV) filter has raised the public concerns over the ecotoxicological effects of these chemicals. The present study assessed the joint toxicity of two representative benzophenones, benzophenon...

  • Article
  • Open Access
16 Citations
6,021 Views
19 Pages

Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation

  • Fatemeh Bahadori,
  • Abdurrahim Kocyigit,
  • Hayat Onyuksel,
  • Aydan Dag and
  • Gulacti Topcu

30 December 2017

Self-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially available nano-formulations...

  • Brief Report
  • Open Access
24 Citations
5,015 Views
5 Pages

27 December 2017

Cadmium exposure can cause several adverse health effects. Animal studies have also shown that cadmium exposure can affect menarche or menopause. However, data is limited in humans. We conducted a retrospective study to assess whether cadmium exposur...

  • Article
  • Open Access
34 Citations
5,152 Views
14 Pages

A Novel Multi-Approach Protocol for the Characterization of Occupational Exposure to Organic Dust—Swine Production Case Study

  • Carla Viegas,
  • Tiago Faria,
  • Ana Monteiro,
  • Liliana Aranha Caetano,
  • Elisabete Carolino,
  • Anita Quintal Gomes and
  • Susana Viegas

27 December 2017

Swine production has been associated with health risks and workers’ symptoms. In Portugal, as in other countries, large-scale swine production involves several activities in the swine environment that require direct intervention, increasing workers’...

  • Feature Paper
  • Article
  • Open Access
19 Citations
5,783 Views
15 Pages

23 December 2017

PCB 11 is an emerging global pollutant that we recently showed promotes axonal and dendritic growth in primary rat neuronal cell cultures. Here, we address the influence of sex and species on neuronal responses to PCB 11. Neuronal morphology was quan...

  • Article
  • Open Access
63 Citations
10,152 Views
9 Pages

The In Vitro Impact of the Herbicide Roundup on Human Sperm Motility and Sperm Mitochondria

  • George Anifandis,
  • George Amiridis,
  • Konstantinos Dafopoulos,
  • Alexandros Daponte,
  • Eleni Dovolou,
  • Eleftherios Gavriil,
  • Vyron Gorgogietas,
  • Elli Kachpani,
  • Zissis Mamuris and
  • Anna-Maria G. Psarra
  • + 2 authors

21 December 2017

Toxicants, such as herbicides, have been hypothesized to affect sperm parameters. The most common method of exposure to herbicides is through spraying or diet. The aim of the present study was to investigate the effect of direct exposure of sperm to...

  • Article
  • Open Access
82 Citations
8,748 Views
13 Pages

The Fate of Glyphosate and AMPA in a Freshwater Endorheic Basin: An Ecotoxicological Risk Assessment

  • Rocío Inés Bonansea,
  • Iohanna Filippi,
  • Daniel Alberto Wunderlin,
  • Damián José Gabriel Marino and
  • María Valeria Amé

21 December 2017

Glyphosate is the most widely used herbicide worldwide. However, there are some uncertain aspects with respect to its environmental fate. To evaluate the existence and distribution of this pesticide and its metabolite, aminomethylphosphonic acid (AMP...

  • Feature Paper
  • Review
  • Open Access
60 Citations
9,742 Views
21 Pages

21 December 2017

Polychlorinated biphenyl (PCB)-contaminated sites around the world affect human health for many years, showing long latency periods of health effects. The impact of the different PCB congeners on human health should not be underestimated, as they are...

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Toxics - ISSN 2305-6304