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Toxics 2018, 6(1), 13; https://doi.org/10.3390/toxics6010013

Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism

1
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Akbarabad, Shiraz 71345-1583, Fars, Iran
2
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319, Iran
3
Department of Pharmacology and Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319, Iran
4
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Jahad Blvd., Kerman 7619813159, Iran
5
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Akbarabad, Shiraz 71345-1583, Fars, Iran
6
Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Shahid Mofateh ST, Tehran 15719-14911, Iran
7
Faculty of Medical Sciences, Jiroft University of Medical Sciences, Pasdaran Blvd, Jiroft 7861615765, Kerman, Iran
8
Deputy of Research and Technology, Jiroft University of Medical Sciences, Pasdaran Blvd, Jiroft 7861615765, Kerman, Iran
*
Author to whom correspondence should be addressed.
Received: 4 December 2017 / Revised: 1 February 2018 / Accepted: 5 February 2018 / Published: 7 February 2018
(This article belongs to the Collection Risk Assessment of Pesticide Exposure)
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Abstract

The widespread use of pesticides in agriculture represents a threat to the human populations exposed to them. In this cross-sectional study, the hematological and biochemical parameters, plasma cholinesterase (PChE) activity, oxidative stress, genotoxicity, and NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism were measured in 100 greenhouse workers occupationally exposed to pesticide mixture and 104 normal healthy controls. There was a decrease in erythrocytes (5.45%, p = 0.026) and hemoglobin (3.26%, p = 0.025), and an increase in mean corpuscular hemoglobin (3.54%, p = 0.013) in the exposed workers. Sprayers showed a reduction in PChE (23%) and GSH (50%) levels, and an increase in lipid peroxidation (LPO) (55%), protein carbonyl (145%), Superoxide dismutase activity (61%), and total antioxidant capacity (35%) (p < 0.001 for all parameters but LPO: p = 0.009). Genotoxicity parameters were significantly high in the exposed cases (for all parameters: p < 0.001 but tail length: p = 0.002). There was a significant correlation between oxidative stress and genotoxicity parameters, and also between these biomarkers and PChE activity. The NQO1 C609T polymorphism was not significantly associated with studied biomarkers. The findings indicate that occupational exposure to a mixture of pesticides can induce hematotoxicity, oxidative stress, and genotoxicity in greenhouse workers. View Full-Text
Keywords: pesticides; oxidative stress; genotoxicity; NQO1; cholinesterase; biomarkers pesticides; oxidative stress; genotoxicity; NQO1; cholinesterase; biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ahmadi, N.; Mandegary, A.; Jamshidzadeh, A.; Mohammadi-Sardoo, M.; Mohammadi-Sardo, M.; Salari, E.; Pourgholi, L. Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism. Toxics 2018, 6, 13.

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