- Article
A Self-Consistent, High-Fidelity Adsorption Model for Chromatographic Process Predictions: Low-to-High Load Density and Charge Variants in a Preparative Cation Exchanger
- Gregor M. Essert,
- Marko Tesanovic,
- Sonja Berensmeier,
- Isabell Hagemann and
- Peter Schwan
The development of ion exchange chromatography to polish biopharmaceuticals requires extensive experimental benchmarking. As part of the Design of Experiments (DoE), statistical models increased efficiency somewhat and are still state of the art; how...

